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Träfflista för sökning "WFRF:(Nilsson Henrik) srt2:(2015-2019)"

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1.	Forsberg, Elin, et al. (author) HER2 CAR-T Cells Eradicate Uveal Melanoma and T-cell Therapy-Resistant Human Melanoma in IL2 Transgenic NOD/SCID IL2 Receptor Knockout Mice 2019 In: Cancer Research. - 0008-5472. ; 79:5, s. 899-904 Journal article (peer-reviewed)abstract Chimeric antigen receptors (CAR) can transmit signals akin to those from activated T-cell receptors when bound to a cell surface target. CAR-expressing T cells against CD19 can cause curative effects in leukemia and lymphoma and is approved for clinical use. However, no CAR-T therapy is currently approved for use in solid tumors. We hypothesize that the resistance of solid tumors to CAR-T can be overcome by similar means as those used to reactivate tumor-infiltrating T lymphocytes (TIL), for example, by cytokines or immune checkpoint blockade. Here we demonstrate that CAR-T cells directed against HER2 can kill uveal and cutaneous melanoma cells in vitro and in vivo. Curative effects in vivo were only observed in xenografts grown in a NOD/SCID IL2 receptor gamma (NOG) knockout mouse strain transgenic for human IL2. The effect was target-specific, as CRISPR/Cas9-mediated disruption of HER2 in the melanoma cells abrogated the killing effect of the CAR-T cells. The CAR-T cells were also able to kill melanoma cells from patients resistant to adoptive T-cell transfer (ACT) of autologous TILs. Thus, CAR-T therapy represents an option for patients that do not respond to immunotherapy with ACT of TIL or immune checkpoint blockade. In addition, our data highlight the use of IL2 transgenic NOG mice as models to prove efficacy of CAR-T-cell products, possibly even in a personalized manner. Significance: These findings demonstrate that a novel humanized mouse model can help clinical translation of CAR-T cells against uveal and cutaneous melanoma that do not respond to TIL therapy or immune checkpoint blockade.
2.	Aad, G, et al. (author) ATLAS Run 1 searches for direct pair production of third-generation squarks at the Large Hadron Collider. 2015 In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 75:10 Journal article (peer-reviewed)
3.	Aad, G, et al. (author) Constraints on the off-shell Higgs boson signal strength in the high-mass ZZ and WW final states with the ATLAS detector. 2015 In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 75:7 Journal article (peer-reviewed)
4.	Aad, G, et al. (author) Determination of the Ratio of b-Quark Fragmentation Fractions f_{s}/f_{d} in pp Collisions at sqrt[s]=7 TeV with the ATLAS Detector. 2015 In: Physical Review Letters. - : American Physical Society. - 1079-7114 .- 0031-9007. ; 115:26 Journal article (peer-reviewed)
5.	Aad, G, et al. (author) Measurement of Spin Correlation in Top-Antitop Quark Events and Search for Top Squark Pair Production in pp Collisions at sqrt[s]=8 TeV Using the ATLAS Detector. 2015 In: Physical Review Letters. - : Elsevier. - 1079-7114 .- 0031-9007. ; 114:14 Journal article (peer-reviewed)
6.	Aad, G, et al. (author) Measurement of the top-quark mass in the fully hadronic decay channel from ATLAS data at [Formula: see text]. 2015 In: The European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6052. ; 75:4 Journal article (peer-reviewed)
7.	Aad, G, et al. (author) Measurements of the Nuclear Modification Factor for Jets in Pb+Pb Collisions at sqrt[s_{NN}]=2.76 TeV with the ATLAS Detector. 2015 In: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 114:7 Journal article (peer-reviewed)
8.	Aad, G, et al. (author) Performance of the ATLAS muon trigger in pp collisions at [Formula: see text] TeV. 2015 In: The European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6052. ; 75:3 Journal article (peer-reviewed)
9.	Aad, G, et al. (author) Search for invisible decays of the Higgs boson produced in association with a hadronically decaying vector boson in pp collisions at [Formula: see text] TeV with the ATLAS detector. 2015 In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 75:7 Journal article (peer-reviewed)
10.	Aad, G, et al. (author) Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at [Formula: see text]TeV with the ATLAS detector. 2015 In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 75:7 Journal article (peer-reviewed)

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Type of publication: journal article (380); conference paper (37); reports (16); book chapter (16); research review (9); doctoral thesis (6); show more...; other publication (5); editorial collection (1); editorial proceedings (1); show less...

Type of content: peer-reviewed (409); other academic/artistic (51); pop. science, debate, etc. (11)

Author/Editor: Alonso, A. (93); Chen, L (92); Aad, G (92); Abbott, B. (92); Abdinov, O (92); Zwalinski, L. (92); show more...; Gregersen, K. (92); Kalderon, C.W. (92); Poettgen, R. (92); Aben, R. (92); Abreu, H. (92); Abreu, R. (92); Adye, T. (92); Agatonovic-Jovin, T. (92); Ahmadov, F. (92); Aielli, G. (92); Albert, J. (92); Albrand, S. (92); Aleksa, M. (92); Aleksandrov, I. N. (92); Alexander, G. (92); Alexopoulos, T. (92); Alhroob, M. (92); Alimonti, G. (92); Alio, L. (92); Alonso, F. (92); Alpigiani, C. (92); Altheimer, A. (92); Amako, K. (92); Amelung, C. (92); Amidei, D. (92); Amorim, A. (92); Amoroso, S. (92); Amram, N. (92); Amundsen, G. (92); Anastopoulos, C. (92); Ancu, L. S. (92); Andari, N. (92); Andeen, T. (92); Anders, G. (92); Anderson, K. J. (92); Andreazza, A. (92); Angelidakis, S. (92); Anger, P. (92); Angerami, A. (92); Anghinolfi, F. (92); Anjos, N. (92); Annovi, A. (92); Antonelli, M. (92); Antonov, A. (92); show less...

University: Lund University (193); Uppsala University (171); Royal Institute of Technology (131); University of Gothenburg (128); Stockholm University (114); Chalmers University of Technology (61); show more...; Karolinska Institutet (48); Linköping University (20); Swedish University of Agricultural Sciences (19); Umeå University (17); Mid Sweden University (14); Malmö University (13); Linnaeus University (12); Stockholm School of Economics (8); RISE (8); Karlstad University (8); Örebro University (7); University West (6); Kristianstad University College (4); Mälardalen University (4); Högskolan Dalarna (4); Swedish Museum of Natural History (3); Red Cross University College (3); Swedish Environmental Protection Agency (2); Luleå University of Technology (1); Halmstad University (1); Jönköping University (1); University of Skövde (1); University of Borås (1); Blekinge Institute of Technology (1); VTI - The Swedish National Road and Transport Research Institute (1); IVL Swedish Environmental Research Institute (1); Royal College of Music (1); show less...

Language: English (443); Swedish (28)

Research subject (UKÄ/SCB): Natural sciences (254); Medical and Health Sciences (142); Social Sciences (78); Engineering and Technology (46); Agricultural Sciences (36); Humanities (8)

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