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- Bellner, Lars, 1973, et al.
(författare)
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Characterization of T-cell reactive epitopes in glycoprotein G of herpes simplex virus type 2 using synthetic peptides.
- 2005
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Ingår i: Archives of virology. - : Springer Science and Business Media LLC. - 0304-8608 .- 1432-8798. ; 150:7, s. 1393-406
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Tidskriftsartikel (refereegranskat)abstract
- We have previously shown that the CD4+ T-cell response to herpes simplex virus type 2 glycoprotein G-2 is type-specific and can thus be used to evaluate herpes simplex virus type 2-specific T-cell responses in individuals with a concomitant herpes simplex virus type 1 infection. In this study we have followed the glycoprotein G-2-specific T-cell responses over time, and also tried to identify T-cell epitopes in the membrane bound portion and the secreted portion of glycoprotein G-2 using synthetic peptides spanning the whole amino acid sequence of glycoprotein G-2. We found that the magnitude of the glycoprotein G-2-specific response varied considerably in infected individuals over time, even though all patients responded to at least one of the two glycoproteins at all time-points examined. We could also document strong T-cell responses to synthetic peptides from the secreted glycoprotein G-2 but only low responses to synthetic peptides corresponding to sequences from the heavily glycosylated membrane-bound glycoprotein G-2. We were able to map an immunogenic region (amino acid 31-125) within the secreted glycoprotein G-2. This region of the glycoprotein induced proliferative responses in 47% of the herpes simplex virus type 2-infected individuals. However, we were not able to identify any universal T-cell epitope.
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- Berggren, Martin, et al.
(författare)
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A discontinuous Galerkin extension of the vertex-centered edge-based finite volume method
- 2009
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Ingår i: Communications in Computational Physics. - 1815-2406. ; 5:2-4, s. 456-468
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Tidskriftsartikel (refereegranskat)abstract
- The finite volume (FV) method is the dominating discretization technique for computational fluid dynamics (CFD), particularly in the case of compressible fluids. The discontinuous Galerkin (DG) method has emerged as a promising high-accuracy alternative. The standard DG method reduces to a cell-centered FV method at lowest order. However, many of today's CFD codes use a vertex-centered FV method in which the data structures are edge based. We develop a new DG method that reduces to the vertex-centered FV method at lowest order, and examine here the new scheme for scalar hyperbolic problems. Numerically, the method shows optimal-order accuracy for a smooth linear problem. By applying a basic hp-adaption strategy, the method successfully handles shocks. We also discuss how to extend the FV edge-based data structure to support the new scheme. In this way, it will in principle be possible to extend an existing code employing the vertex-centered and edge-based FV discretization to encompass higher accuracy through the new DG method.
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- Börstler, Jürgen, 1960-, et al.
(författare)
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Evaluating OO Example Programs for CS1
- 2008
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Ingår i: Proceedings of the 13th annual conference on Innovation and technology in computer science education. - New York, NY, USA : ACM. ; , s. 47-52
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Konferensbidrag (refereegranskat)
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- Börstler, Jürgen, 1960-, et al.
(författare)
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Transitioning to OOP/Java : A never ending story
- 2008
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Ingår i: Reflections on the teaching of programming. - Berlin, Heidelberg : Springer. - 9783540779339 ; , s. 80-97
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Bokkapitel (refereegranskat)
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- Carpenter, Mark H., et al.
(författare)
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Revisiting and extending interface penalties for multi-domain summation-by-parts operators
- 2009
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- A general interface procedure is presented for multi-domain collocation methods satisfying the summation-by-parts (SBP) spatial discretization convention. Unlike more traditional operators (e.g. FEM) applied to the advection-diffusion equation, the new procedure penalizes the solution and the first p derivatives across the interface. The combined interior/interface operators are proven to be pointwise stable, and conservative, although accuracy deteriorates for p>=2. Penalties between two different sets of variables are compared (motivated by FEM primal and flux formulations), and are shown to be equivalent for certain choices of penalty parameters. Extensive validation studies are presented using two classes of high-order SBP operators: 1) central finite difference, and 2) Legendre spectral collocation.
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