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- Lagerspetz, E., et al.
(author)
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Pervasive Communities in the Internet of People
- 2018
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In: 2018 IEEE International Conference on Pervasive Computing and Communications Workshops, PerCom Workshops 2018. - : Institute of Electrical and Electronics Engineers Inc.. - 9781538632277 ; , s. 40-45
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Conference paper (peer-reviewed)abstract
- The Internet has traditionally been a device-oriented architecture where devices with IP addresses are first-class citizens, able to serve and consume content or services, and their owners take part in the interaction only through those devices. The Internet of People (IoP) is a recent paradigm where devices become proxies of their users, and can act on their behalf. To realize IoP, new policies and rules for how devices can take actions are required. The role of context information grows as devices act autonomously based on the environment and existing social relationships between their owners. In addition, the social profiles of device owners determine e.g. how altruistic or resourceconserving they are in collaborative computing scenarios. In this paper we focus on community formation in IoP, a prerequisite for enabling collaborative scenarios, and discuss main challenges and propose potential solutions. © 2018 IEEE.
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- Saliba-Gustafsson, P., et al.
(author)
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Subclinical atherosclerosis and its progression are modulated by PLIN2 through a feed-forward loop between LXR and autophagy
- 2019
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In: Journal of Internal Medicine. - : Wiley. - 0954-6820 .- 1365-2796. ; 286:6, s. 660-675
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Journal article (peer-reviewed)abstract
- Background Hyperlipidaemia is a major risk factor for cardiovascular disease, and atherosclerosis is the underlying cause of both myocardial infarction and stroke. We have previously shown that the Pro251 variant of perilipin-2 reduces plasma triglycerides and may therefore be beneficial to reduce atherosclerosis development. Objective We sought to delineate putative beneficial effects of the Pro251 variant of perlipin-2 on subclinical atherosclerosis and the mechanism by which it acts. Methods A pan-European cohort of high-risk individuals where carotid intima-media thickness has been assessed was adopted. Human primary monocyte-derived macrophages were prepared from whole blood from individuals recruited by perilipin-2 genotype or from buffy coats from the Karolinska University hospital blood central. Results The Pro251 variant of perilipin-2 is associated with decreased intima-media thickness at baseline and over 30 months of follow-up. Using human primary monocyte-derived macrophages from carriers of the beneficial Pro251 variant, we show that this variant increases autophagy activity, cholesterol efflux and a controlled inflammatory response. Through extensive mechanistic studies, we demonstrate that increase in autophagy activity is accompanied with an increase in liver-X-receptor (LXR) activity and that LXR and autophagy reciprocally activate each other in a feed-forward loop, regulated by CYP27A1 and 27OH-cholesterol. Conclusions For the first time, we show that perilipin-2 affects susceptibility to human atherosclerosis through activation of autophagy and stimulation of cholesterol efflux. We demonstrate that perilipin-2 modulates levels of the LXR ligand 27OH-cholesterol and initiates a feed-forward loop where LXR and autophagy reciprocally activate each other; the mechanism by which perilipin-2 exerts its beneficial effects on subclinical atherosclerosis.
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