| 1. |
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
- Cronin, T. M., et al.
(author)
-
Holocene paleoceanography and glacial history of Lincoln Sea, Ryder Glacier, Northern Greenland, based on foraminifera and ostracodes
- 2022
-
In: Marine Micropaleontology. - : Elsevier BV. - 0377-8398 .- 1872-6186. ; 175
-
Journal article (peer-reviewed)abstract
- We reconstructed Holocene paleoceanography of the Sherard Osborn Fjord (SOF), N Greenland, and Lincoln Sea in the eastern Arctic Ocean using sediment properties and micropaleontology from cores obtained during the Ryder 2019 Expedition. Our aims were to better understand faunal indicators of water mass influence on Ryder Glacier and the Lincoln Sea at water depths >500 m. Benthic microfaunal reflect glacio-marine interval during late deglaciation ~10.5 to 8.5 ka (kiloannum) during the Holocene Thermal Maximum (HTM) with dominant benthic foraminiferal species Cassidulina neoteretis, Cassidulina reniforme, and the ostracode Rabilimis mirabilis. Casssidulina neoteretis is considered an indicator of Atlantic Water (AW) throughout the Arctic Ocean and Nordic Seas; C. reniforme reflects glacio-marine conditions from the retreating Ryder Glacier. Deglaciation was followed by a period of elevated productivity and diverse ostracode faunal assemblages that suggest AW influence from 8.5 to 6 ka in the Lincoln Sea and inside SOF. The Holocene occurrence of the ostracode species Acetabulastoma arcticum, that appears in low numbers in the Lincoln Sea and briefly (~ 4–3 ka) in SOF, reflects the presence of variable sea ice in this region. Based on the similarities of the Lincoln Sea and fjord ostracodes to modern and glacial-deglacial faunas from the central Arctic Ocean, the AW influence likely originates from recirculation of AW water from the central Arctic Basin. In general, our results suggest a strong but temporally varying influence of AW during the entire 10.5 kyr record of the Lincoln Sea and SOF.
|
|
| 5. |
- O'Regan, Ruth M., et al.
(author)
-
Breast Cancer Index in Premenopausal Women With Early-Stage Hormone Receptor-Positive Breast Cancer
- 2024
-
In: JAMA ONCOLOGY. - 2374-2437 .- 2374-2445.
-
Journal article (peer-reviewed)abstract
- Importance Adjuvant ovarian function suppression (OFS) with oral endocrine therapy improves outcomes for premenopausal patients with hormone receptor-positive (HR+) breast cancer but adds adverse effects. A genomic biomarker for selecting patients most likely to benefit from OFS-based treatment is lacking. Objective To assess the predictive and prognostic performance of the Breast Cancer Index (BCI) for OFS benefit in premenopausal women with HR+ breast cancer. Design, Setting, and Participants This prospective-retrospective translational study used all available tumor tissue samples from female patients from the Suppression of Ovarian Function Trial (SOFT). These individuals were randomized to receive 5 years of adjuvant tamoxifen alone, tamoxifen plus OFS, or exemestane plus OFS. BCI testing was performed blinded to clinical data and outcome. The a priori hypothesis was that BCI HOXB13/IL17BR ratio (BCI[H/I])-high tumors would benefit more from OFS and high BCI portended poorer prognosis in this population. Settings spanned multiple centers internationally. Participants included premenopausal female patients with HR+ early breast cancer with specimens in the International Breast Cancer Study Group tumor repository available for RNA extraction. Data were collected from December 2003 to April 2021 and were analyzed from May 2022 to October 2022. Main Outcomes and Measures Primary end points were breast cancer-free interval (BCFI) for the predictive analysis and distant recurrence-free interval (DRFI) for the prognostic analyses. Results Tumor specimens were available for 1718 of the 3047 female patients in the SOFT intention-to-treat population. The 1687 patients (98.2%) who had specimens that yielded sufficient RNA for BCI testing represented the parent trial population. The median (IQR) follow-up time was 12 (10.5-13.4) years, and 512 patients (30.3%) were younger than 40 years. Tumors were BCI(H/I)-low for 972 patients (57.6%) and BCI(H/I)-high for 715 patients (42.4%). Patients with tumors classified as BCI(H/I)-low exhibited a 12-year absolute benefit in BCFI of 11.6% from exemestane plus OFS (hazard ratio [HR], 0.48 [95% CI, 0.33-0.71]) and an absolute benefit of 7.3% from tamoxifen plus OFS (HR, 0.69 [95% CI, 0.48-0.97]) relative to tamoxifen alone. In contrast, patients with BCI(H/I)-high tumors did not benefit from either exemestane plus OFS (absolute benefit, -0.4%; HR, 1.03 [95% CI, 0.70-1.53]; P for interaction = .006) or tamoxifen plus OFS (absolute benefit, -1.2%; HR, 1.05 [95% CI, 0.72-1.54]; P for interaction = .11) compared with tamoxifen alone. BCI continuous index was significantly prognostic in the N0 subgroup for DRFI (n = 1110; P = .004), with 12-year DRFI of 95.9%, 90.8%, and 86.3% in BCI low-risk, intermediate-risk, and high-risk N0 cancers, respectively. Conclusions and Relevance In this prospective-retrospective translational study of patients enrolled in SOFT, BCI was confirmed as prognostic in premenopausal women with HR+ breast cancer. The benefit from OFS-containing adjuvant endocrine therapy was greater for patients with BCI(H/I)-low tumors than BCI(H/I)-high tumors. BCI(H/I)-low status may identify premenopausal patients who are likely to benefit from this more intensive endocrine therapy.
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
- Heiss, M., et al.
(author)
-
Self-assembled quantum dots in a nanowire system for quantum photonics
- 2013
-
In: Nature Materials. - 1476-4660. ; 12:5, s. 439-444
-
Journal article (peer-reviewed)abstract
- Quantum dots embedded within nanowires represent one of the most promising technologies for applications in quantum photonics. Whereas the top-down fabrication of such structures remains a technological challenge, their bottom-up fabrication through self-assembly is a potentially more powerful strategy. However, present approaches often yield quantum dots with large optical linewidths, making reproducibility of their physical properties difficult. We present a versatile quantum-dot-innanowire system that reproducibly self-assembles in core-shell GaAs/AlGaAs nanowires. The quantum dots form at the apex of a GaAs/AlGaAs interface, are highly stable, and can be positioned with nanometre precision relative to the nanowire centre. Unusually, their emission is blue-shifted relative to the lowest energy continuum states of the GaAs core. Large-scale electronic structure calculations show that the origin of the optical transitions lies in quantum confinement due to Al-rich barriers. By emitting in the red and self-assembling on silicon substrates, these quantum dots could therefore become building blocks for solid-state lighting devices and third-generation solar cells.
|
|
| 10. |
|
|
