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Träfflista för sökning "WFRF:(Oguz C) srt2:(2007-2009)"

Search: WFRF:(Oguz C) > (2007-2009)

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  • Yilmaz, MI, et al. (author)
  • Improving proteinuria, endothelial functions and asymmetric dimethylarginine levels in chronic kidney disease: ramipril versus valsartan
  • 2007
  • In: Blood purification. - : S. Karger AG. - 1421-9735 .- 0253-5068. ; 25:4, s. 327-335
  • Journal article (peer-reviewed)abstract
    • <i>Background:</i> The aim of this study was to find out whether the beneficial effects of the renin-angiotensin-aldosterone system (RAS) blockage in chronic kidney disease (CKD) has any relation with the alteration of asymmetric dimethylarginine (ADMA) levels. <i>Methods:</i> Sixty-six nondiabetic patients with CKD and proteinuria and 36 healthy subjects were enrolled. Patients were treated with either ramipril 5 mg daily or valsartan 160 mg daily for 3 months. Proteinuria, ADMA, symmetric dimethyl arginine (SDMA), flow-mediated dilatation (FMD) and HOMA index measurements were performed both before and after the treatment. <i>Results:</i> ADMA, SDMA, hsCRP levels, HOMA index and proteinuria of patients were significantly higher (p < 0.001 for all) and FMD, <i>L</i>-arginine and <i>L</i>-arginine/ADMA ratio in CKD were significantly lower than controls. According to the multiple regression analysis, proteinuria levels were independently related to ADMA and SDMA levels. <i>Conclusion:</i> Both drugs were equally effective in reducing elevated ADMA levels and improving endothelial dysfunction in CKD patients.
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  • Result 1-2 of 2
Type of publication
journal article (2)
Type of content
peer-reviewed (2)
Author/Editor
Yilmaz, MI (2)
Caglar, K (2)
Saglam, M (2)
Cakir, E (2)
Eyileten, T (2)
Yenicesu, M (2)
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Oguz, Y (2)
Vural, A (2)
Acikel, C (2)
Carrero, JJ (1)
Stenvinkel, P (1)
Lindholm, B (1)
Axelsson, J (1)
Sonmez, A (1)
Tasar, M (1)
Kurt, Y (1)
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University
Karolinska Institutet (2)
Language
English (2)

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