| 1. |
- Engert, Andreas, et al.
(författare)
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The European Hematology Association Roadmap for European Hematology Research : a consensus document
- 2016
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Ingår i: Haematologica. - Pavia, Italy : Ferrata Storti Foundation (Haematologica). - 0390-6078 .- 1592-8721. ; 101:2, s. 115-208
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Tidskriftsartikel (refereegranskat)abstract
- The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at (sic)23 billion per year, a level of cost that is not matched in current European hematology research funding. In recent decades, hematology research has improved our fundamental understanding of the biology of blood disorders, and has improved diagnostics and treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap. The EHA Roadmap identifies nine 'sections' in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders. The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients.
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| 2. |
- Shungin, Dmitry, et al.
(författare)
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New genetic loci link adipose and insulin biology to body fat distribution.
- 2015
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 187-378
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Tidskriftsartikel (refereegranskat)abstract
- Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
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| 3. |
- Kehoe, Laura, et al.
(författare)
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Make EU trade with Brazil sustainable
- 2019
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 4. |
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| 5. |
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| 6. |
- Ayoglu, Burcu, et al.
(författare)
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Anoctamin 2 identified as an autoimmune target in multiple sclerosis
- 2016
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : National Academy of Sciences of the USA. - 0027-8424 .- 1091-6490. ; 113:8, s. 2188-2193
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Tidskriftsartikel (refereegranskat)abstract
- Multiple sclerosis (MS) is the most common chronic inflammatory disease of the central nervous system and also is regarded as an autoimmune condition. However, the antigenic targets of the autoimmune response in MS have not yet been deciphered. In an effort to mine the autoantibody repertoire within MS, we profiled 2,169 plasma samples from MS cases and population-based controls using bead arrays built with 384 human protein fragments selected from an initial screening with 11,520 antigens. Our data revealed prominently increased autoantibody reactivity against the chloride-channel protein anoctamin 2 (ANO2) in MS cases compared with controls. This finding was corroborated in independent assays with alternative protein constructs and by epitope mapping with peptides covering the identified region of ANO2. Additionally, we found a strong interaction between the presence of ANO2 autoantibodies and the HLA complex MS-associated DRB1*15 allele, reinforcing a potential role for ANO2 autoreactivity in MS etiopathogenesis. Furthermore, immunofluorescence analysis in human MS brain tissue showed ANO2 expression as small cellular aggregates near and inside MS lesions. Thus this study represents one of the largest efforts to characterize the autoantibody repertoire within MS. The findings presented here demonstrate that an ANO2 autoimmune subphenotype may exist in MS and lay the groundwork for further studies focusing on the pathogenic role of ANO2 autoantibodies in MS.
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| 7. |
- Costa, Sergio, 1987, et al.
(författare)
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Improvement and validation of a physically based model for the shear and transverse crushing of orthotropic composites
- 2019
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Ingår i: Journal of Composite Materials. - : SAGE Publications. - 1530-793X .- 0021-9983. ; 53:12, s. 1681-1696
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Tidskriftsartikel (refereegranskat)abstract
- This paper details a complete crush model for composite materials with focus on shear dominated crushing under a three-dimensional stress state. The damage evolution laws and final failure strain conditions are based on data extracted from shear experiments. The main advantages of the current model include the following: no need to measure the fracture toughness in shear and transverse compression, mesh objectivity without the need for a regular mesh and finite element characteristic length, a pressure dependency of the nonlinear shear response, accounting for load reversal and some orthotropic effects (making the model suitable for noncrimp fabric composites). The model is validated against a range of relevant experiments, namely a through-the-thickness compression specimen and a flat crush coupon with the fibres oriented at 45° and 90° to the load. Damage growth mechanisms, orientation of the fracture plane, nonlinear evolution of Poisson's ratio and energy absorption are accurately predicted.
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| 8. |
- Costa, Sergio, 1987, et al.
(författare)
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Validation of a novel model for the compressive response of FRP: Numerical simulation
- 2017
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Ingår i: ICCM International Conferences on Composite Materials. ; 2017-August
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Konferensbidrag (refereegranskat)abstract
- A progressive damage model for matrix compression is complemented with matrix tension in a physically based manner. The interaction of damage mechanisms undergoes a preliminary validation using single elements. The crushing response is validated with two different flat specimens with the fibres oriented transversely and at 45 degrees to the load. The model combines friction with damage to model the shear response accurately, which is necessary for reliable crush simulations. The behaviour in tension is history dependent, i.e. the model accounts for the stiffness reduction and strength to carry load in tension when previously damaged occurs in compression. The validation is performed against different tests showing the reliability of the model for different fibre orientation, specimen geometry and multiaxial loading scenarios. The crush response is well captured as well as the geometry and location of the different damage mechanisms.
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| 9. |
- Helland, Christian, et al.
(författare)
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Training Strategies to Improve Muscle Power : Is Olympic-style Weightlifting Relevant?
- 2017
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Ingår i: Medicine & Science in Sports & Exercise. - Philadelphia, PA : Lippincott Williams & Wilkins. - 0195-9131 .- 1530-0315. ; 49:4, s. 736-745
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Tidskriftsartikel (refereegranskat)abstract
- INTRODUCTION: This efficacy study investigated the effects of (1) Olympic-style weightlifting (OWL), (2) motorized strength and power training (MSPT), and (3) free weight strength and power training (FSPT) on muscle power.METHODS: Thirty-nine young athletes (20±3 yr.; ice hockey, volleyball and badminton) were randomized into the three training groups. All groups participated in 2-3 sessions/week for 8 weeks. The MSPT and FSPT groups trained using squats (two legs and single leg) with high force and high power, while the OWL group trained using clean and snatch exercises. MSPT was conducted as slow-speed isokinetic strength training and isotonic power training with augmented eccentric load, controlled by a computerized robotic engine system. FSPT used free weights. The training volume (sum of repetitions x kg) was similar between all three groups. Vertical jumping capabilities were assessed by countermovement jump (CMJ), squat jump (SJ), drop jump (DJ), and loaded CMJs (10-80 kg). Sprinting capacity was assessed in a 30 m sprint. Secondary variables were squat 1-repetition-maximum, body composition and quadriceps thickness and architecture.RESULTS: OWL resulted in trivial improvements, and inferior gains compared to FSPT and MSPT for CMJ, SJ, and DJ. MSPT demonstrated small, but robust effects on SJ, DJ and loaded CMJs (3-12%). MSPT was superior to FSPT in improving 30 m sprint performance. FSPT and MSPT, but not OWL, demonstrated increased thickness in the vastus lateralis and rectus femoris (4-7%).CONCLUSION: MSPT was time-efficient and equally or more effective than FSPT training in improving vertical jumping and sprinting performance. OWL was generally ineffective and inferior to the two other interventions. Copyright © 2016 by the American College of Sports Medicine.
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| 10. |
- Keogan, Katharine, et al.
(författare)
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Global phenological insensitivity to shifting ocean temperatures among seabirds
- 2018
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Ingår i: Nature Climate Change. - : Springer Science and Business Media LLC. - 1758-678X .- 1758-6798. ; 8:4, s. 313-318
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Tidskriftsartikel (refereegranskat)abstract
- Reproductive timing in many taxa plays a key role in determining breeding productivity(1), and is often sensitive to climatic conditions(2). Current climate change may alter the timing of breeding at different rates across trophic levels, potentially resulting in temporal mismatch between the resource requirements of predators and their prey(3). This is of particular concern for higher-trophic-level organisms, whose longer generation times confer a lower rate of evolutionary rescue than primary producers or consumers(4). However, the disconnection between studies of ecological change in marine systems makes it difficult to detect general changes in the timing of reproduction(5). Here, we use a comprehensive meta-analysis of 209 phenological time series from 145 breeding populations to show that, on average, seabird populations worldwide have not adjusted their breeding seasons over time (-0.020 days yr(-1)) or in response to sea surface temperature (SST) (-0.272 days degrees C-1) between 1952 and 2015. However, marked between-year variation in timing observed in resident species and some Pelecaniformes and Suliformes (cormorants, gannets and boobies) may imply that timing, in some cases, is affected by unmeasured environmental conditions. This limited temperature-mediated plasticity of reproductive timing in seabirds potentially makes these top predators highly vulnerable to future mismatch with lower-trophic-level resources(2).
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