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Search: WFRF:(Olsson Martin L.) > (2015-2019)

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  • Pulit, S. L., et al. (author)
  • Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes
  • 2018
  • In: Neurology-Genetics. - : Ovid Technologies (Wolters Kluwer Health). - 2376-7839. ; 4:6
  • Journal article (peer-reviewed)abstract
    • Objective We sought to assess whether genetic risk factors for atrial fibrillation (AF) can explain cardioembolic stroke risk. We evaluated genetic correlations between a previous genetic study of AF and AF in the presence of cardioembolic stroke using genome-wide genotypes from the Stroke Genetics Network (N = 3,190 AF cases, 3,000 cardioembolic stroke cases, and 28,026 referents). We tested whether a previously validated AF polygenic risk score (PRS) associated with cardioembolic and other stroke subtypes after accounting for AF clinical risk factors. We observed a strong correlation between previously reported genetic risk for AF, AF in the presence of stroke, and cardioembolic stroke (Pearson r = 0.77 and 0.76, respectively, across SNPs with p < 4.4 x 10(-4) in the previous AF meta-analysis). An AF PRS, adjusted for clinical AF risk factors, was associated with cardioembolic stroke (odds ratio [OR] per SD = 1.40, p = 1.45 x 10(-48)), explaining similar to 20% of the heritable component of cardioembolic stroke risk. The AF PRS was also associated with stroke of undetermined cause (OR per SD = 1.07,p = 0.004), but no other primary stroke subtypes (all p > 0.1). Genetic risk of AF is associated with cardioembolic stroke, independent of clinical risk factors. Studies are warranted to determine whether AF genetic risk can serve as a biomarker for strokes caused by AF.
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  • Result 1-10 of 106
Type of publication
journal article (83)
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Type of content
peer-reviewed (68)
other academic/artistic (37)
Author/Editor
Olsson, Martin L (35)
Olsson, T (32)
Piehl, F (27)
Hillert, J (23)
Lycke, J (23)
Nilsson, P. (22)
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Martin, C (22)
Dahle, C. (22)
Forsberg, L. (22)
Svenningsson, A (16)
Landtblom, A. -M (13)
Walentin, F. (12)
Burman, J. (11)
Fält, A. (10)
Burman, Joachim, 197 ... (9)
Hunter, J (9)
Landtblom, Anne-Mari ... (8)
Robinson, S. (8)
Zheng, Y. (8)
Das, S. (8)
Diaz, R. (8)
Diaz, A. (8)
Aboyans, V (8)
Takahashi, T. (8)
Seferovic, P (8)
Katz, A. (8)
Anderson, J. (8)
Scott, D. (8)
Ilic, S. (8)
Jukema, JW (8)
Kim, C. (8)
Ristic, AD (8)
Ferrari, E. (8)
Park, H. (8)
Collins, N (8)
Storry, Jill (8)
Storry, Jill R (8)
Larsen, J (8)
Takeda, Y (8)
Sakamoto, T. (8)
Leclercq, F. (8)
White, L (8)
Merkely, B (8)
Adamkova, V. (8)
Yusoff, K. (8)
Garrido, M (8)
Fras, Z (8)
de Silva, HA (8)
Bhatt, DL (8)
Malhotra, V. (8)
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Karolinska Institutet (58)
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Uppsala University (35)
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