| 1. |
- Aglago, Elom K., et al.
(author)
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Dietary Advanced Glycation End-Products and Colorectal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study
- 2021
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In: Nutrients. - : MDPI. - 2072-6643. ; 13:9
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Journal article (peer-reviewed)abstract
- Dietary advanced glycation end-products (dAGEs) have been hypothesized to be associated with a higher risk of colorectal cancer (CRC) by promoting inflammation, metabolic dysfunction, and oxidative stress in the colonic epithelium. However, evidence from prospective cohort studies is scarce and inconclusive. We evaluated CRC risk associated with the intake of dAGEs in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Dietary intakes of three major dAGEs: Nε-carboxy-methyllysine (CML), Nε-carboxyethyllysine (CEL), and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) were estimated in 450,111 participants (median follow-up = 13 years, with 6162 CRC cases) by matching to a detailed published European food composition database. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations of dAGEs with CRC were computed using multivariable-adjusted Cox regression models. Inverse CRC risk associations were observed for CML (HR comparing extreme quintiles: HRQ5vs.Q1 = 0.92, 95% CI = 0.85-1.00) and MG-H1 (HRQ5vs.Q1 = 0.92, 95% CI = 0.85-1.00), but not for CEL (HRQ5vs.Q1 = 0.97, 95% CI = 0.89-1.05). The associations did not differ by sex or anatomical location of the tumor. Contrary to the initial hypothesis, our findings suggest an inverse association between dAGEs and CRC risk. More research is required to verify these findings and better differentiate the role of dAGEs from that of endogenously produced AGEs and their precursor compounds in CRC development.
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| 2. |
- Bounechada, Djamela, 1984, et al.
(author)
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Mechanisms behind sulfur promoted oxidation of methane
- 2013
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In: Physical Chemistry Chemical Physics. - : Royal Society of Chemistry (RSC). - 1463-9084 .- 1463-9076. ; 15:22, s. 8648-8661
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Journal article (peer-reviewed)abstract
- The promoting effect of SO2 on the activity for methane oxidation over platinum supported on silica, alumina and ceria has been studied by flow-reactor, in situ infrared spectroscopy and in situ high-energy x-ray diffraction experiments under transient reaction conditions. The catalytic activity is clearly dependent on the support material and its interaction with the noble metal both in absence and presence of sulfur. On platinum, the competitive reactant adsorption favors oxygen dissociation such that oxygen self-poisoning is observed for Pt/silica and Pt/alumina. Contrarily for Pt/ceria, no oxygen self-poisoning is observed, which seems to be due to additional reaction channels via sites on the platinum-ceria boundary and/or ceria surface considerably far from the Pt crystallites. Addition of sulfur dioxide generally leads to the formation of ad-SOx species on the supports with a concomitant removal and/or blockage/rearrangement of surface hydroxyl groups. Thereby, the methane oxidation is inhibited for Pt/silica, enhanced for Pt/alumina and temporary enhanced followed by inhibition after long-term exposure to sulfur for Pt/ceria. The observations can be explained by competitive oxidation of SO2 and CH4 on Pt/silica, formation of new active sites at the noble metal-support interface promoting dissociative adsorption of methane on Pt/alumina, and in the case of Pt/ceria, formation of promoting interfacial surface sulfates followed by formation of deactivating bulk-like sulfate species. Furthermore, it can be excluded that reduction of detrimental high oxygen coverage and/or oxide formation on the platinum particles through SO2 oxidation is the main cause for the promotional effects observed.
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| 3. |
- Carré, Helena, 1979-, et al.
(author)
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[Contact tracing a year back is worthwhile. Follow the Vasterbottens example to prevent Chlamydia transmission in Sweden!]
- 2005
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In: Läkartidningen. - 0023-7205 .- 1652-7518. ; 102:7, s. 468-71
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Journal article (peer-reviewed)abstract
- Contact tracing is proved to be a good way to prevent asymptomatic sexually transmitted infections, such as Chlamydia trachomatis, from spreading. According to the Swedish law a physician has to report all cases of genital C. trachomatis to the County Medical Officer of Health and to the National institute for Infectious Disease Control and perform contact tracing. An evaluation of the sexual history 6 months back in time is recommended and standard in most of the country. The county of Västerbotten has one of the lowest incidenses of C. trachomatis in Sweden though the population is younger than the Swedish average. During year 2002 the contact tracing in Västerbotten was evaluated by sending a questionnaire to everyone who reported a case of genital C. trachomatis. We recived 534 (98%) out of 544 questionnaires. The patients reported 1360 partners, 2.5 on average, 1129 were identified. 761 had a known test result and 497 of them were positive, 0.9 on average. 72% of the contact tracers evaluated the sexual history > or = 12 months back in time. 78% of the contact tracings were performed by four social workers. Their patients reported 2.5 partners on average and 80% evaluated > or = 12 months back in time. 14 persons did only one contact tracing, 1.3 partners/index on average, 40% evaluated > or = 12 months back in time. 82% of the partners had sex with the infected patient 0-6 months before the patients was diagnosed with C. trachomatis, 75% out of those with a known test result were infected, 16% had sex 7-12 months before diagnosis, 30% infected. (The C. trachomatis prevalence in Sweden is estimated to be 2.7-4.9% among young women.) Conclusion: A few experienced persons tracing for at least 12 month back in time is probably two important reasons why Västerbotten has such a small C. trachomatis incidence.
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| 4. |
- Drevenhorn, Eva, 1954, et al.
(author)
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A content analysis of patient-centredness in hypertension care after consultation training for nurses .
- 2007
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In: The Internet Journal of Advanced Nursing Practice. - : Internet Scientific Publications. - 1523-6064. ; 8:2
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Journal article (peer-reviewed)abstract
- Lifestyle changes are important when it comes to reducing the risk factors for cardiovascular complications. There is evidence that these changes are more successful if counselling is conducted in a patient-centred way. The purpose was to analyse how nurses used patient-centred counselling with hypertensive patients after video-recorded consultation training. Nineteen nurses from nurse-led clinics in hypertension care at Swedish health centres participated in residential counselling. Two audio-recordings with hypertensive patients in regular practice were made before and after the training and analysed with the emphasis on patient centredness. Weighing up the pros and cons, the identification of beliefs about treatment and negotiations about the reasons for and where to begin behavioural change increased. A slight increase in reflections and pauses was observed. Expansive and provocative questions and the identification of goals or goal-setting were used sparsely. As a result of the training, the nurses gave individually-adapted information more frequently.
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| 5. |
- Fortes, Bartira, et al.
(author)
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Contesting Extractivism through Amazonian Indigenous Artivism : Decolonial reflections on possibilities for crafting a pluriverse from within
- 2023
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In: Alternautas. - : Alternautas. - 2057-4924. ; 10:1, s. 155-190
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Journal article (peer-reviewed)abstract
- This article provides an analysis of Amazonian Indigenous peoples’ “artivism” – understood as artistic expressions with activist orientation. It approaches artivism within the context of the emergence of Contemporary Indigenous Art in Brazil and its significance in the resistance against the centuries-long oppression of native peoples, illustrated by the advancement of extractivism in the Amazon. We focus on the artworks by four prominent Indigenous artivists: Jaider Esbell’s critical engagements with art history; Denilson Baniwa’s reanthropophagy movement; Daiara Tukano’s critique of articide; and Emerson Pontes’ transformation into Uýra, the Walking Tree. Altogether, the messages embedded in their artworks contest the dominant growth-oriented development narrative anchored on the pre-eminence of the human-nature ontological dualism, where Nature is reduced to economic resource, along with a view of development that positions western ways of knowing, being and living at the forefront of a civilizational continuum. We conclude by elucidating the central decolonizing role of Indigenous artivism and its potential to strengthen Indigenous’ voices and agendas which include exercising self-determination, resisting extractivism, and crafting more plural and just worlds.
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| 6. |
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| 7. |
- Murin, Yu., et al.
(author)
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A detector system for studying nuclear reactions relevant to Single Event Effects
- 2007
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In: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576 .- 0167-5087. ; 578:2, s. 385-398
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Journal article (peer-reviewed)abstract
- We describe a device to study reactions relevant for the Single Event Effect (SEE) in microelectronics by means of 200A and 300AMeV, inverse kinematics, Si + H and Si + D reactions. The work is focused on the possibility to measure Z = 2-14 projectile fragments as efficiently as possible. During commissioning and first experiments the fourth quadrant of the CELSIUS storage ring acted as a spectrometer to register fragments in two planes of Si strip detectors in the angular region 0 degrees-0.6 degrees. A combination of ring-structured and sector-structured Si strip detector planes operated at angles 0.6 degrees-1.1 degrees. For specific event tagging a Si+ phoswich scintillator wall operated in the range 3.9 degrees-11.7 degrees and Si Delta E-E telescopes of CHICSi type operated at large angles.
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| 8. |
- Oberstedt, A., et al.
(author)
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Time response and its impact on prompt fission gamma-ray spectra characteristics
- 2020
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In: European Physical Journal A. - : Springer Nature. - 1434-6001 .- 1434-601X. ; 56:7
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Journal article (peer-reviewed)abstract
- The time dependence of prompt gamma-ray spectral characteristics, in particular themultiplicity, was studied during the first 10 ns after the spontaneous fission of Cf-252. The impact of prompt window and experimental time resolution on the determination of prompt multiplicities is assessed and described mathematically. As a consequence we are able to offer corrections that allow a reliable comparison of results from different measurements. An apparent discrepancy between a theoretical and an experimentally found time dependence is explained by the influence of a finite experimental timing resolution as well as the choice of the prompt timing window.
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| 9. |
- Oscarsson, Jan, 1960, et al.
(author)
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Effects of growth hormone on lipoprotein lipase and hepatic lipase.
- 1999
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In: Journal of endocrinological investigation. - 0391-4097. ; 22:5 Suppl, s. 2-9
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Research review (peer-reviewed)abstract
- Lipoprotein lipase (LPL) is a key enzyme in the regulation of the flux of fatty acids. LPL hydrolyses triglycerides in chylomicrons and very-low-density lipoproteins (VLDL), forming intermediate- (IDL) and low-density lipoproteins (LDL). Hepatic lipase (HL) is a related enzyme with a more restricted tissue distribution than LPL; HL is mainly engaged in the turnover of IDL and of high-density lipoproteins (HDL). Both enzymes can be released from their endothelial sites by heparin and their activities measured separately in post-heparin plasma (PHP). The PHP-LPL activity decreases in hypophysectomized rats and this effect is reversed by growth hormone (GH) therapy. However, GH seems to have no effect, or an inhibitory effect, on PHP-LPL activity in humans. Muscle and adipose tissues are the main sources of PHP-LPL activity. One week of GH therapy of hypophysectomized rats increases skeletal muscle and heart LPL activity. In this model, GH has little or no effect on LPL activity in adipose tissue. However, GH has been shown to decrease LPL activity in isolated rat adipose tissue. Insulin-like growth factor-I therapy decreases and insulin therapy increases LPL activity in adipose tissue of hypophysectomized rats, whereas these therapies have no effect on LPL activity in muscle tissue. The LPL activity in human adipose tissue is reduced both in vivo and in vitro after administration of GH while the LPL mRNA level is unchanged. The effect of GH on HL activity has been studied in PHP and liver. Several studies in the rat indicate that GH increases PHP-HL and liver HL activity, at least partly at the level of mRNA expression. In humans, GH has been shown to have variable effects on PHP-HL activity; this variability is probably to some extent dependent on different experimental set-ups. Although GH therapy increases hepatic secretion of VLDL, serum triglyceride levels decrease as a result of GH therapy in the hypophysectomized rat. An increase in HL and LPL activity by GH therapy is in line with these findings. In summary, GH is involved in the regulation of both LPL and HL activity but the effects and mechanisms of action of GH in the regulation of LPL and HL activity in different tissues are not yet fully elucidated.
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