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- Meinander, K., et al.
(author)
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Pseudopeptides with a centrally positioned alkene-based disulphide bridge mimetic stimulate kallikrein-related peptidase 3 activity
- 2013
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In: Medchemcomm. - : Royal Society of Chemistry (RSC). - 2040-2503 .- 2040-2511. ; 4:3, s. 549-553
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Journal article (peer-reviewed)abstract
- Pseudopeptides based on the kallikrein-related peptidase 3 (KLK3) activating bicyclic peptide “C-4” comprising hydrocarbon-based disulphide bridge mimetics have been synthesized. After investigating different synthetic approaches, the pseudopeptides were successfully cyclized from two L-allylglycine side chains via an alkene ring-closing metathesis reaction during the peptide synthesis. The alkene-linker was formed in a 1 : 1 E/Z isomer ratio. The resulting pseudopeptides were almost as potent as the parent peptide, increasing the activity of KLK3 over four-fold at 200 μg ml−1 (130–140 μM) concentrations.
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- Rintamaki, PT, et al.
(author)
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Blood parasites of migrating Willow Warblers (Phylloscopus trochilus) at a stopover site
- 1998
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In: CANADIAN JOURNAL OF ZOOLOGY-REVUE CANADIENNE DE ZOOLOGIE. - : NATL RESEARCH COUNCIL CANADA. - 0008-4301. ; 76:5, s. 984-988
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Journal article (other academic/artistic)abstract
- Populations are often difficult to separate on the basis of morphometric data. However, since blood parasites have shown significantly different prevalences and parasitaemias in natural host populations, such discrepancies may provide an opportunity of st
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