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1.	Ajileye, Adebisi, et al. (author) Some Synonymous and Nonsynonymous gyrA Mutations in Mycobacterium tuberculosis Lead to Systematic False-Positive Fluoroquinolone Resistance Results with the Hain GenoType MTBDRsl Assays 2017 In: Antimicrobial Agents and Chemotherapy. - : AMER SOC MICROBIOLOGY. - 0066-4804 .- 1098-6596. ; 61:4 Journal article (peer-reviewed)abstract In this study, using the Hain GenoType MTBDRsl assays (versions 1 and 2), we found that some nonsynonymous and synonymous mutations in gyrA in Mycobacterium tuberculosis result in systematic false-resistance results to fluoroquinolones by preventing the binding of wild-type probes. Moreover, such mutations can prevent the binding of mutant probes designed for the identification of specific resistance mutations. Although these mutations are likely rare globally, they occur in approximately 7% of multidrug-resistant tuberculosis strains in some settings.
2.	Nakatani, Yoshio, et al. (author) Role of Alanine Racemase Mutations in Mycobacterium tuberculosis D-Cycloserine Resistance 2017 In: Antimicrobial Agents and Chemotherapy. - : AMER SOC MICROBIOLOGY. - 0066-4804 .- 1098-6596. ; 61:12 Journal article (peer-reviewed)abstract A screening of more than 1,500 drug-resistant strains of Mycobacterium tuberculosis revealed evolutionary patterns characteristic of positive selection for three alanine racemase (Alr) mutations. We investigated these mutations using molecular modeling, in vitro MIC testing, as well as direct measurements of enzymatic activity, which demonstrated that these mutations likely confer resistance to D-cycloserine.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Schön, Thomas (2); Merker, Matthias (2); Moradigaravand, Dane ... (2); Coll, Francesc (2); Diel, Roland (2); Parkhill, Julian (2); show more...; Niemann, Stefan (2); Peacock, Sharon J. (2); Swaminathan, Soumya (1); Ajileye, Adebisi (1); Alvarez, Nataly (1); Walker, Timothy M. (1); Akter, Suriya (1); Brown, Kerstin (1); Andres, Soenke (1); Schleusener, Viola (1); Omar, Shaheed V. (1); Huang, Hairong (1); Ismail, Nazir (1); de Jong, Bouke C. (1); Peto, Tim E. A. (1); Crook, Derrick W. (1); Robledo, Jaime (1); Grace Smith, E. (1); Koeser, Claudio U. (1); Cook, Gregory M. (1); Andres, Sonke (1); Clark, Taane G. (1); Perdigao, Joao (1); Portugal, Isabel (1); Viveiros, Miguel (1); Koser, Claudio U. (1); Machado, Diana (1); Beckert, Patrick (1); Kohl, Thomas A. (1); Nakatani, Yoshio (1); Opel-Reading, Helen ... (1); Siva Kumar, S. (1); Nair, Dina (1); Uma Devi, K. R. (1); Maphalala, Gugu (1); Khumalo, Derrick (1); Klaos, Kadri (1); Lin Aung, Htin (1); Krause, Kurt L. (1); show less...

University: Linköping University (2)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

Year: 2017 (2)Undo refine

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