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Träfflista för sökning "WFRF:(Peloso GM) srt2:(2021)"

Search: WFRF:(Peloso GM) > (2021)

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  • Niemi, MEK, et al. (author)
  • 2021
  • swepub:Mat__t
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3.
  • Huffman, J, et al. (author)
  • Alternative splicing of OAS1 alters the risk for severe COVID-19
  • 2021
  • In: medRxiv : the preprint server for health sciences. - : Cold Spring Harbor Laboratory.
  • Journal article (other academic/artistic)abstract
    • A locus containing OAS1/2/3 has been identified as a risk locus for severe COVID-19 among Europeans ancestry individuals, with a protective haplotype of ∼75 kilobases derived from Neanderthals. Here, we show that among several potentially causal variants at this locus, a splice variant of OAS1 occurs in people of African ancestry independently of the Neanderthal haplotype and confers protection against COVID-19 of a magnitude similar to that seen in individuals without African ancestry.
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