| 1. |
- Abrahamsson, Marcus, et al.
(author)
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A study of the performance of risk and vulnerability assessments by Swedish Public Agencies
- 2012
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In: Proceedings of the 4th International Disaster and Risk Conference: Integrative Risk Management in a Changing World - Pathways to a Resilient Society, IDRC Davos 2012. ; , s. 15-18
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Conference paper (peer-reviewed)abstract
- Risk and vulnerability assessments (RVA) are vital components of the work conducted by public agencies at different levels, as part of the processes for governing and managing risks in the society. In Sweden, public agencies at all levels are required by legislation to perform risk and vulnerability assessments within their respective area of responsibility. The present paper presents a study of how Swedish municipalities, county administrative boards and national authorities work with RVAs, with a special focus on three aspects of such assessments that are highlighted in the legislation: vital societal functions, critical dependencies, and capability assessment. The main data collection technique was semi-structured interviews and a total of 25 actors were included and interviewed. The goal was to achieve a good representation of the different actors that perform RVAs. Thus 5 national authorities, 5 county administrative boards, and 15 municipalities were chosen in order to obtain a representative functional distribution (in terms of national authorities responsible for different sectors), geographic distribution as well as size distribution. The study shows that there is rather large variety of approaches, perspectives and views adopted by different actors, all with different advantages and drawbacks. It is argued that the findings of the study can be used to improve the RVA-practices of public authorities.
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| 2. |
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| 3. |
- Becker, Per, et al.
(author)
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Final report: A participatory method for need based capacity development projects and programmes
- 2011
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Reports (other academic/artistic)abstract
- The three-year research project funded by MSB applies design science, in combination with traditional scientific investigation, to develop a method to guide the planning phase of capacity development projects for disaster risk reduction and climate change adaptation. The method facilitates local participation and ownership as it builds on the strengths of the Logical Framework Approach (LFA), while contextualising it to suit capacity development for disaster risk management and climate change adaptation.
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| 5. |
- Borell, Jonas, et al.
(author)
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Krishantering och lärande
- 2010
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In: FRIVA - risk, sårbarhet och förmåga. - 9789163376917 ; , s. 155-163
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Book chapter (other academic/artistic)
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| 6. |
- Cedergren, Alexander, et al.
(author)
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Learning from accident investigations – A cross-country comparison
- 2010
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In: Proceedings 10th International Probabilistic Safety Assessment & Management Conference..
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Conference paper (peer-reviewed)abstract
- This paper compares all accident investigation reports covering railway accidents issued by the national investigation boards in Sweden, Norway and Denmark during a two-year period (2008-2009). By using content analysis, units of text describing attributed causes have been selected and categorized as belonging to one of three hierarchical levels; the micro level (technical malfunctioning and human actions), meso level (organizational actions and factors in the physical environment), and macro level (inter-organizational and regulatory factors). In addition, attributed causes on each level have been further categorized as belonging to different ‘types’ of causes. In a similar manner the recommendations described in all studied reports have been divided into different classes. The results show that the majority of attributed causes in all three countries belong to the micro level, and about half of all recommendations aim at human factors aspects. Furthermore, the diversity in different ‘types’ of causes differs between the countries. The analysis has been followed up by interviews with the investigation boards. Based on these interviews, it can be concluded that the structure, mandate and traditions of the investigation boards influences the outcome of the investigations in such way that a broader mandate gives rise to a higher potential for accidents to be examined from multiple perspectives.
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| 7. |
- Cedergren, Alexander, et al.
(author)
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Prerequisites for learning from accident investigations - A cross-country comparison of national accident investigation boards
- 2011
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In: Safety Science. - : Elsevier BV. - 0925-7535. ; 49:8-9, s. 1238-1245
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Journal article (peer-reviewed)abstract
- In this paper railway accident investigation reports issued by the national accident investigation boards in three Scandinavian countries during a 2-year period have been systematically studied. Content analysis of attributed causes in these reports reveals a considerable emphasis on physical processes, actor activities and equipment (the microlevel). Much less attention is paid to organisational factors (the mesolevel) and conditions related to regulators, associations and government (the macrolevel). This means that lessons will primarily be learned about aspects at the lower of these levels. Interviews show that the factors emphasised in investigation reports typically reflect the competences and experiences of the investigators, i.e. they are inclined to focus on areas of their own expertise. Since failures at the microlevel in many cases merely are symptoms of trouble at higher levels, it is argued that competence among investigators that supplements entirely technical or operational backgrounds are necessary for enabling deeper understanding of the factors leading to accidents. One possible way for achieving this is the creation of multi-modal investigation boards that provide a number of potential advantages, such as increased access to specialist competences that are shared between different sectors. Although a multi-modal approach to some degree has been adopted in all three countries, interviews reveal that these positive effects do not emerge automatically. It can therefore be concluded that multi-modal investigation boards offer a number of possible advantages, but only when these synergies are fully exploited can they provide a potential for more effective learning from accidents. (C) 2011 Elsevier Ltd. All rights reserved.
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| 8. |
- Coviello, Andrea D, et al.
(author)
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A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
- 2012
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In: PLoS genetics. - : Public Library of Science (PLoS). - 1553-7404 .- 1553-7390. ; 8:7
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Journal article (peer-reviewed)abstract
- Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has been associated with chronic diseases including type 2 diabetes (T2D) and with hormone-sensitive cancers such as breast and prostate cancer. We performed a genome-wide association study (GWAS) meta-analysis of 21,791 individuals from 10 epidemiologic studies and validated these findings in 7,046 individuals in an additional six studies. We identified twelve genomic regions (SNPs) associated with circulating SHBG concentrations. Loci near the identified SNPs included SHBG (rs12150660, 17p13.1, p=1.8×10(-106)), PRMT6 (rs17496332, 1p13.3, p=1.4×10(-11)), GCKR (rs780093, 2p23.3, p=2.2×10(-16)), ZBTB10 (rs440837, 8q21.13, p=3.4×10(-09)), JMJD1C (rs7910927, 10q21.3, p=6.1×10(-35)), SLCO1B1 (rs4149056, 12p12.1, p=1.9×10(-08)), NR2F2 (rs8023580, 15q26.2, p=8.3×10(-12)), ZNF652 (rs2411984, 17q21.32, p=3.5×10(-14)), TDGF3 (rs1573036, Xq22.3, p=4.1×10(-14)), LHCGR (rs10454142, 2p16.3, p=1.3×10(-07)), BAIAP2L1 (rs3779195, 7q21.3, p=2.7×10(-08)), and UGT2B15 (rs293428, 4q13.2, p=5.5×10(-06)). These genes encompass multiple biologic pathways, including hepatic function, lipid metabolism, carbohydrate metabolism and T2D, androgen and estrogen receptor function, epigenetic effects, and the biology of sex steroid hormone-responsive cancers including breast and prostate cancer. We found evidence of sex-differentiated genetic influences on SHBG. In a sex-specific GWAS, the loci 4q13.2-UGT2B15 was significant in men only (men p=2.5×10(-08), women p=0.66, heterogeneity p=0.003). Additionally, three loci showed strong sex-differentiated effects: 17p13.1-SHBG and Xq22.3-TDGF3 were stronger in men, whereas 8q21.12-ZBTB10 was stronger in women. Conditional analyses identified additional signals at the SHBG gene that together almost double the proportion of variance explained at the locus. Using an independent study of 1,129 individuals, all SNPs identified in the overall or sex-differentiated or conditional analyses explained ∼15.6% and ∼8.4% of the genetic variation of SHBG concentrations in men and women, respectively. The evidence for sex-differentiated effects and allelic heterogeneity highlight the importance of considering these features when estimating complex trait variance.
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