| 1. |
- Sokka, T., et al.
(author)
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Disparities in rheumatoid arthritis disease activity according to gross domestic product in 25 countries in the QUEST-RA database
- 2009
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In: Annals of the Rheumatic Diseases. - : BMJ. - 0003-4967 .- 1468-2060. ; 68:11, s. 1666-1672
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Journal article (peer-reviewed)abstract
- Objective: To analyse associations between the clinical status of patients with rheumatoid arthritis ( RA) and the gross domestic product (GDP) of their resident country. Methods: The Quantitative Standard Monitoring of Patients with Rheumatoid Arthritis (QUEST-RA) cohort includes clinical and questionnaire data from 6004 patients who were seen in usual care at 70 rheumatology clinics in 25 countries as of April 2008, including 18 European countries. Demographic variables, clinical characteristics, RA disease activity measures, including the disease activity score in 28 joints (DAS28), and treatment-related variables were analysed according to GDP per capita, including 14 "high GDP'' countries with GDP per capita greater than US$ 24 000 and 11 "low GDP'' countries with GDP per capita less than US$ 11 000. Results: Disease activity DAS28 ranged between 3.1 and 6.0 among the 25 countries and was significantly associated with GDP (r = -0.78, 95% CI -0.56 to -0.90, r(2) = 61%). Disease activity levels differed substantially between "high GDP'' and "low GDP'' countries at much greater levels than according to whether patients were currently taking or not taking methotrexate, prednisone and/or biological agents. Conclusions: The clinical status of patients with RA was correlated significantly with GDP among 25 mostly European countries according to all disease measures, associated only modestly with the current use of antirheumatic medications. The burden of arthritis appears substantially greater in "low GDP'' than in "high GDP'' countries. These findings may alert healthcare professionals and designers of health policy towards improving the clinical status of patients with RA in all countries.
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| 2. |
- Devlic, Alisa, et al.
(author)
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Context inference of users' social relationships and distributed policy management
- 2009
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In: 7th Annual IEEE International Conference on Pervasive Computing and Communications, PerCom 2009. - : IEEE. - 9781424433049 ; , s. 778-785
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Conference paper (peer-reviewed)abstract
- Inference of high-level context is becoming crucial in development of context-aware applications. An example is social context inference i.e., deriving social relations based upon the user's daily communication with other people. The efficiency of this mechanism mnaimily depends on the method(s) used to draw inferences based on existing evidence and sample information, such as a training data. Our approach uses rule-based data mining. Bayesian network inference, and user feedback to compute the probabilities of another user being in the specific social relationship with a user whose daily communication is logged by a mobile phone. In addition, a privacy mechanism is required to ensure the user's personal integrity and privacy when sharing this user's sensitive context data. Therefore, the derived social relations are used to define a user's policies for context access control, which grant the restricted context information scope depending on the user's current context. Finally, we propose a distributed architecture capable of managing this context information based upon these context access policies.
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| 3. |
- Montanier, Cedric, et al.
(author)
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The Active Site of a Carbohydrate Esterase Displays Divergent Catalytic and Noncatalytic Binding Functions
- 2009
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In: PLoS Biology. - : Public Library of Science (PLoS). - 1545-7885. ; 7:3, s. 687-697
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Journal article (peer-reviewed)abstract
- Multifunctional proteins, which play a critical role in many biological processes, have typically evolved through the recruitment of different domains that have the required functional diversity. Thus the different activities displayed by these proteins are mediated by spatially distinct domains, consistent with the specific chemical requirements of each activity. Indeed, current evolutionary theory argues that the colocalization of diverse activities within an enzyme is likely to be a rare event, because it would compromise the existing activity of the protein. In contrast to this view, a potential example of multifunctional recruitment into a single protein domain is provided by CtCel5C-CE2, which contains an N-terminal module that displays cellulase activity and a C-terminal module, CtCE2, which exhibits a noncatalytic cellulose-binding function but also shares sequence identity with the CE2 family of esterases. Here we show that, unlike other CE2 members, the CtCE2 domain displays divergent catalytic esterase and noncatalytic carbohydrate binding functions. Intriguingly, these diverse activities are housed within the same site on the protein. Thus, a critical component of the active site of CtCE2, the catalytic Ser-His dyad, in harness with inserted aromatic residues, confers noncatalytic binding to cellulose whilst the active site of the domain retains its esterase activity. CtCE2 catalyses deacetylation of noncellulosic plant structural polysaccharides to deprotect these substrates for attack by other enzymes. Yet it also acts as a cellulose-binding domain, which promotes the activity of the appended cellulase on recalcitrant substrates. The CE2 family encapsulates the requirement for multiple activities by biocatalysts that attack challenging macromolecular substrates, including the grafting of a second, powerful and discrete noncatalytic binding functionality into the active site of an enzyme. This article provides a rare example of "gene sharing,'' where the introduction of a second functionality into the active site of an enzyme does not compromise the original activity of the biocatalyst.
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| 4. |
- Fernandez-Aranda, F, et al.
(author)
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Symptom profile of major depressive disorder in women with eating disorders
- 2007
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In: The Australian and New Zealand journal of psychiatry. - : SAGE Publications. - 0004-8674 .- 1440-1614. ; 41:1, s. 24-31
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Journal article (peer-reviewed)abstract
- Objective: Based on the well-documented association between eating disorders (EDs) and affective disorders, the patterns of comorbidity of EDs and major depressive disorder (MDD) were investigated. The temporal relation between EDs and MDD onset was analyzed to determine differences in the course and nature of MDD when experienced prior to versus after the onset of the ED. Method: Lifetime MDD and depressive symptoms were assessed in 1371 women with a history of ED. The prevalence of MDD was first explored across ED subtypes, and ages of onset of MDD and EDs were compared. Depressive symptoms were examined in individuals who developed MDD before and after ED onset. Results: The lifetime prevalence of MDD was 72.9%. Among those with lifetime MDD (n =963), 34.5% reported MDD onset before the onset of ED. Those who experienced MDD first reported greater psychomotor agitation (OR =1.53; 95%CI =1.14–2.06), and thoughts of own death (but not suicide attempts or ideation; OR =1.73; 95%CI =1.31–2.30). Among individuals who had MDD before ED, 26.5% had the MDD onset during the year before the onset of ED; 67% of individuals had the onset of both disorders within the same 3 year window. Conclusion: Clinicians treating individuals with new-onset ED or MDD should remain vigilant for the emergence of additional psychopathology, especially during the initial 3 year window following the onset of the first disorder.
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| 5. |
- Kirsch-Pinheiro, M., et al.
(author)
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Context grouping mechanism for context distribution in ubiquitous environments
- 2008
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In: OTM 2008 Confederated International Conferences CoopIS, DOA, GADA, IS, and ODBASE 2008. - Berlin, Heidelberg : Springer Berlin Heidelberg. - 3540888705 - 9783540888703 ; , s. 571-588
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Conference paper (peer-reviewed)abstract
- Context distribution is a key aspect for successful applications within mobile and ubiquitous computing environments. In such environments, context information is acquired by several and multiple context sensors distributed over the environment. Applications collect and react to these data, according to predefined adaptation mechanisms. The success of these mechanisms depends on the availability of context information, which is disseminated over the network. However, in practice, only a fraction of the observable context information is required by the adaptation mechanisms. Moreover, for privacy reasons, it is important to delimitate a scope for context dissemination. In this work we address these issues by proposing a context grouping mechanism which allows the definition of groups based on the context characteristics. Each group is defined by these characteristics and delimitate a given context information set that can be distributed among group members. This approach of context grouping acts as a two-fold mechanism. On the one hand, it controls and organizes context distribution over a peer-to-peer network. On the other hand, it proposes a primary and low-level privacy mechanism for context distribution, which is an important aspect influencing context distribution.
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| 6. |
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| 7. |
- von Holle, A, et al.
(author)
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Temporal patterns of recovery across eating disorder subtypes
- 2008
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In: The Australian and New Zealand journal of psychiatry. - : SAGE Publications. - 0004-8674 .- 1440-1614. ; 42:2, s. 108-117
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Journal article (peer-reviewed)abstract
- Objective: To compare patterns of recovery in individuals with index episodes of anorexia nervosa (AN) and bulimia nervosa (BN). Method: Using Kaplan–Meier methods and Cox proportional hazards models, comparisons were conducted that were conditional on duration of eating disorder from onset and included a conservative recovery criterion of 3 asymptomatic years. Data collection was retrospective and from two of the international Price Foundation genetic studies on 901 individuals with eating disorders. Results: Using Kaplan–Meier methods, 11% of those with index AN and 10% of those with index BN met recovery criteria at 10 years. At 15 years, 16% of those with index AN and 25% of those with index BN met recovery criteria. In a Cox proportional hazards model the index BN group had three times the rate of recovery at 10–14 years (p=0.01) than the index AN group. Conclusions: Initially the probability of recovery was greater for those with index AN, but as the duration of the eating disorder lengthened those with BN had higher probabilities of recovery. Replication of these results with prospective data using similarly stringent recovery criteria and methods is required to confirm trends.
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| 8. |
- Araújo, M.S., et al.
(author)
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Network analysis reveals contrasting effects of intraspecific competition on individual versus population diets
- 2008
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In: Ecology. - : Wiley. - 0012-9658 .- 1939-9170. ; 89:7, s. 1981-1993
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Journal article (peer-reviewed)abstract
- Optimal foraging theory predicts that individuals should become more opportunistic when intraspecific competition is high and preferred resources are scarce. This density-dependent diet shift should result in increased diet breadth for individuals as they add previously unused prey to their repertoire. As a result, the niche breadth of the population as a whole should increase. In a recent study, R. Svanback and D. I. Bolnick confirmed that intraspecific competition led to increased population diet breadth in threespine stickleback (Gasterosteus aculeatus). However, individual diet breadth did not expand as resource levels declined. Here, we present a new method based on complex network theory that moves beyond a simple measure of diet breadth, and we use the method to reexamine the stickleback experiment. This method reveals that the population as a whole added new types of prey as stickleback density was increased. However, whereas foraging theory predicts that niche expansion is achieved by individuals accepting new prey in addition to previously preferred prey, we found that a subset of individuals ceased to use their previously preferred prey, even though other members of their population continued to specialize on the original prey types. As a result, populations were subdivided into groups of ecologically similar individuals, with diet variation among groups reflecting phenotype-dependent changes in foraging behavior as prey density declined. These results are consistent with foraging theory if we assume that quantitative trait variation among consumers affects prey preferences, and if cognitive constraints prevent individuals from continuing to use their formerly preferred prey while adding new prey.
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