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Träfflista för sökning "WFRF:(Popovic R.) srt2:(2000-2004)"

Search: WFRF:(Popovic R.) > (2000-2004)

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  • Gosch, M., et al. (author)
  • Parallel single molecule detection with a fully integrated single-photon 2X2 CMOS detector array
  • 2004
  • In: Journal of Biomedical Optics. - : SPIE-Intl Soc Optical Eng. - 1083-3668 .- 1560-2281. ; 9:5, s. 913-921
  • Journal article (peer-reviewed)abstract
    • We present parallel single molecule detection (SMD) and fluorescence correlation spectroscopy (FCS) experiments with a fully integrated complementary metal oxide semiconductor (CMOS) single-photon 2 X 2 detector array. Multifocal excitation is achieved with a diffractive optical element (DOE). Special emphasis is placed on parallelization of the total system. The performance of the novel single-photon CMOS detector is investigated and compared to a state-of-the-art single-photon detecting module [having an actively quenched avalanche photodiode (APD)] by measurements on free diffusing molecules at different concentrations. Despite the order of magnitude lower detection efficiency of the CMOS detector compared to the state-of-the-art single-photon detecting module, we achieve single molecule sensitivity and reliably determine molecule concentrations. In addition, the CMOS detector performance for the determination of the fraction of slowly diffusing molecules in a primer solution (two-component analysis) is demonstrated. The potential of this new technique for high-throughput confocal-detection-based systems is discussed.
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  • Result 1-2 of 2
Type of publication
journal article (2)
Type of content
other academic/artistic (1)
peer-reviewed (1)
Author/Editor
Rigler, R (2)
Gosch, M. (2)
Serov, A (2)
Lasser, T. (2)
Rochas, A. (2)
Blom, Hans (1)
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Anhut, T. (1)
Besse, P. A. (1)
Popovic, R. S. (1)
Besse, PA (1)
Popovic, RS (1)
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University
Karolinska Institutet (2)
Royal Institute of Technology (1)
Language
English (2)
Research subject (UKÄ/SCB)
Engineering and Technology (1)

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