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Träfflista för sökning "WFRF:(Pratt A) srt2:(2000-2004)"

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1.	Pratt, P., et al. (author) A quantitative flow visualization of a point source disturbance in a swept wing boundary layer 2001 In: Abstracts of Euromech colloquium 423, Stuttgart, Germany. ; , s. 56-57 Conference paper (other academic/artistic)
2.	Berhe, A, et al. (author) Properties of the Cysteine-less Pho84 Phosphate Transporter of Saccharomyces cerevisiae 2001 In: Biochemical and biophysical research communications. ; 287:4, s. 837- 842 Journal article (peer-reviewed)
3.	Lagerstedt, Jens, et al. (author) Mutagenic and Functional Analysis of the C-terminus of Saccharomyces cerevisiae Pho84 Phosphate Transporter 2002 In: FEBS letters. - 0014-5793. ; 526, s. 31-37 Journal article (peer-reviewed)
4.	Lagerstedt, Jens O., et al. (author) Mutagenic and functional analysis of the C-terminus of Saccharomyces cerevisiae Pho84 phosphate transporter. 2002 In: FEBS Letters. - 0014-5793. ; 526:1-3, s. 31-37 Journal article (peer-reviewed)
5.	McLaughlin, David, et al. (author) Specific modification of heparan sulphate is required for normal cerebral cortical development 2003 In: Mechanisms of Development. - : Elsevier. - 0925-4773 .- 1872-6356. ; 120:12, s. 1481-1488 Journal article (peer-reviewed)abstract Proteoglycans are cell surface and extracellular matrix molecules to which long, unbranched glycosaminoglycan side chains are attached. Heparan sulphate, a type of glycosaminoglycan chain, has been proposed as a co-factor necessary for signalling by a range of growth factors. Here we provide evidence that loss of 2-O-sulphation in heparan sulphate leads to a significant reduction in cell proliferation in the developing cerebral cortex. The gene encoding heparan sulphate 2-sulphotransferase (Hs2st) is expressed in embryonic cortex and histological analysis of mice homozygous for a null mutation in Hs2st indicated a reduction in the thickness of the embryonic cerebral cortex. Using 5′-bromodeoxyuridine (BrdU) incorporation assays we found a reduction of approximately 40% in labelling indices of cortical precursor cells at E12. Comparison of the fates of cortical cells born on E13 and E15 in Hs2st−/− mutant and wildtype littermate embryos revealed no differences in the pattern of cell migration. Our findings suggest a critical role for 2-O-sulphation of heparan sulphate proteoglycan (HSPG) in regulating cell proliferation during development of the cerebral cortex, perhaps through the modulation of cellular responses to growth factor signalling.

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Type of publication: journal article (4); conference paper (1)

Type of content: peer-reviewed (4); other academic/artistic (1)

Author/Editor: Persson, Bengt L. (3); Zvyagilskaya, Renata (3); Pattison-Granberg, J ... (2); Löfdahl, Lennart, 19 ... (1); Lagerstedt, Jens (1); Price, David J. (1); show more...; Lagerstedt, Jens O. (1); Bakchinov, A.A. (1); Chernoray, Valery, 1 ... (1); Berhe, A (1); Lagerstedt, J O (1); Pratt, J R (1); Berden, J (1); Bullock, Simon L. (1); Karlsson, Fredrik, 1 ... (1); Pratt, James (1); Kruckeberg, A L (1); Pratt, James R. (1); Kruckeberg, Arthur L ... (1); Berden, Jan A. (1); McLaughlin, David (1); Tian, Natasha (1); Pratt, Thomas (1); Wilson, Valerie A. (1); Mason, John O. (1); Pratt, P. (1); show less...

University: Stockholm University (3); Linnaeus University (2); Chalmers University of Technology (1); Högskolan Dalarna (1)

Language: English (4); Undefined language (1)

Research subject (UKÄ/SCB): Natural sciences (1); Engineering and Technology (1); Medical and Health Sciences (1)

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