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- Hussain, Sajid, et al.
(author)
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Families of Extended Exponentiated Generalized Distributions and Applications of Medical Data Using Burr III Extended Exponentiated Weibull Distribution
- 2023
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In: Mathematics. - 2227-7390. ; 11:14
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Journal article (peer-reviewed)abstract
- In this article, four new families named as Weibull extended exponentiated-X (WEE-X), Lomax extended exponentiated-X (LEE-X), Logistic extended exponentiated-X (LGCEE-X), and Burr III extended exponentiated-X (BIIIEE-X) with their quantile functions are proposed. The expressions for distribution function and density function of BIIIEE-X family are written in terms of linear combinations of the exponentiated densities based to parent model. New models, i.e., Weibul extended exponentiated Weibull (WEEW), Lomax extended exponentiated Weibull (LEEW), Logistic extended exponentiated Weibull (LGCEEW), and Burr III extended exponentiated-Weibull (BIIIEEW) distributions are derived, were plotted for functions of probability density and hazard rate at different levels of parameters. Some mathematical properties of the BIIIEEW model are disclosed. The maximum likelihood method for the BIIIEEW model are described. Numerical applications of the BIIIEEW model to disease of cancer datasets are provided.
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- Hussain, Sajid, et al.
(author)
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The Exponentiated Power Alpha Index Generalized Family of Distributions : Properties and Applications
- 2023
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In: Mathematics. - : MDPI AG. - 2227-7390. ; 11:4, s. 900-900
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Journal article (peer-reviewed)abstract
- The study of hydrological characteristics has a vital role in designing, planning, and managing water resources. The selection of appropriate probability distributions and methods of estimations are basic elements in hydrology analyses. In this article, a new family named the ‘exponentiated power alpha index generalized’ (EPAIG)-G is proposed to develop several new distributions. Using this proposed family, we developed a new model, called the EPAIG-exponential (EPAIG-E). A few structural properties of the EPAIG-G were obtained. The EPAIG-E parameters were estimated through the method of maximum likelihood (MML). The study of the Monte Carlo simulation (MCS) was produced for the EPAIG-E. The model performance is illustrated using real data.
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- Hussain, Sajid, et al.
(author)
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The Generalized Alpha Exponent Power Family of Distributions : Properties and Applications
- 2022
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In: Mathematics. - : MDPI AG. - 2227-7390. ; 10:9
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Journal article (peer-reviewed)abstract
- Here, a new method is recommended to characterize a new continuous distribution class, named the generalized alpha exponent power family of distributions (GAEPFDs). A particular sub-model is presented for exemplifying the objective. The basic statistical properties, such as ordinary moments, the probability weighted moments, mode, quantile, order statistics, entropy measures, and moment generating functions, etc., were explored. To gauge the GAEPPRD parameters, the ML technique was utilized. The estimator behaviour was studied by a Monte Carlo simulation study (MCSS). The effectiveness of GAEPFDs was demonstrated observationally through lifetime data. The applications show that GAEPFDs can offer preferable results over other competitive models.
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- Hussain, Sajid, et al.
(author)
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The Generalized Exponential Extended Exponentiated Family of Distributions : Theory, Properties, and Applications
- 2022
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In: Mathematics. - : MDPI AG. - 2227-7390. ; 10:19
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Journal article (peer-reviewed)abstract
- Here, we propose a new generalized exponential extended exponentiated (NGE3) family of distributions. Some statistical properties of proposed family are gained. The most extreme probability method, maximum likelihood (ML), is utilized for parameter estimation. We explore an exceptional model called NGE3-Exponential (NGE3E). NGE3E is estimated with ML, and the performance of estimators is demonstrated by utilizing a simulation. Moreover, two applications are given to show the significance and adaptability of the proposed model in comparison to some generalized models (GMs).
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- Kassimu, Kamaka, et al.
(author)
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Safety and Tolerability of an Antimalarial Herbal Remedy in Healthy Volunteers : An Open-Label, Single-Arm, Dose-Escalation Study on Maytenus senegalensis in Tanzania
- 2022
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In: Tropical Medicine and Infectious Disease. - : MDPI. - 2414-6366. ; 7:12
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Journal article (peer-reviewed)abstract
- Background: Though Maytenus senegalensis is one of the medicinal plants widely used in traditional medicine to treat infectious and inflammatory diseases in Africa, there is a lack of safety data regarding its use. Therefore, the study aimed to asselss the safety and tolerability of the antimalarial herbal remedy M. senegalensis. Material and Methods: The study design was an open-label, single-arm, dose-escalation. Twelve eligible male healthy Tanzanians aged 18 to 45 years were enrolled in four study dose groups. Volunteers' safety and tolerability post-investigational-product administration were monitored on days 0 to 7,14, and 56. Results: There were no deaths or serious adverse events in any of the study groups, nor any adverse events that resulted in premature discontinuation. The significant mean changes observed in WBC (p = 0.003), Neutrophils (p = 0.02), Lymphocytes (p = 0.001), Eosinophils (p = 0.009), Alanine aminotransferase (p = 0.002), Creatinine (p = 0.03) and Total bilirubin (p = 0.004) laboratory parameters were not associated with any signs of toxicity or clinical symptoms. Conclusions: M. senegalensis was demonstrated to be safe and tolerable when administered at a dose of 800 mg every eight hours a day for four days. This study design may be adapted to evaluate other herbal remedies.
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- Noreen, Khadija, et al.
(author)
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Algorithms to obtain generalized neighbor designs in minimal circular blocks
- 2022
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In: Communications in statistics. Simulation and computation. - : Taylor & Francis. - 0361-0918 .- 1532-4141.
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Journal article (peer-reviewed)abstract
- The experiments where response of a treatment (direct effect) is affected by the treatment(s) applied in neighboring units, neighbor designs are used to balance the neighbor effects. Being the economical, minimal neighbor designs are preferred by the experimenters. Minimal circular neighbor designs could not be constructed for almost every case of v even, where v is number of treatments. For v even, minimal circular generalized neighbor designs are preferred. In this article, algorithms are developed to obtain minimal circular generalized neighbor designs in which (a) v/2 of the unordered pairs, and (b) 3v/2 of the unordered pairs, do not appear as neighbor whereas the remaining ones appear once. These algorithms are also coded with R-language.
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- Sabir Rashid, Avan, et al.
(author)
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Homonymous visual field defect and retinal thinning after occipital stroke
- 2021
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In: Brain and Behavior. - : Wiley-Blackwell. - 2162-3279 .- 2162-3279. ; 11:10
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Journal article (peer-reviewed)abstract
- Introduction Stroke is the most common cause of homonymous visual field defects (VFD). About half of the stroke patients recover from VFD. However, relationship between VFD and retinal changes remains elusive. Purpose To investigate the association between occurrence of VFD, changes of macular ganglion cell and inner plexiform layer (GCIPL) and its axon retinal nerve fiber layer (RNFL) detected with optical coherence tomography (OCT). Patients and methods The study consists of retrospective review of medical records and follow-up examinations. Patients with acute occipital stroke were registered. VFD was identified with confrontation and/or perimetry tests at the onset. At follow-up, the patients were examined with visual field tests and OCT measurements. Results Thirty-six patients met the inclusion criteria. At onset, 26 patients (72%) had VFD. At follow-up >1 year after stroke, 13 patients (36%) had remaining VFD: 5 had homonymous hemianopia, 5 had homonymous quadrantanopia, and 3 had homonymous scotomas. Average thickness of GCIPL and RNFL were significantly reduced in each eye in patients with VFD compared to non-VFD (NVFD) (p < .01 for all comparisons). Thickness of superior and inferior RNFL quadrants was significantly reduced in VFD compared to NVFD (p < .01 for both). Among these 13 patients, 4 had characteristic homonymous quadrant-GCIPL thinning, 2 had characteristic homonymous hemi-GCIPL thinning, and 7 had diffuse GCIPL thinning. Conclusion GCIPL and RNFL thinning were observed in the patients with VFD. GCIPL thinning appears in two forms: atypical diffuse thinning, or homonymous hemi-GCIPL thinning. Examining GCIPL and RNFL provides easy and reliable objective measures and is therefore proposed to be of predictive value on visual function.
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