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- Jacquet, J M, et al.
(author)
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Safety and immunogenicity of a combined DTPa-IPV vaccine administered as a booster from 4 years of age : a review
- 2006
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In: Vaccine. - : Elsevier BV. - 0264-410X .- 1873-2518. ; 24:13, s. 2440-2448
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Journal article (peer-reviewed)abstract
- A combined DTPa-IPV booster vaccine was administered as a 4th or 5th dose after DTPa or DTPw priming. Over 99% vaccines developed antibody levels considered to be protective to diphtheria, tetanus and poliovirus, and >95% mounted a response to acellular pertussis antigens. Rectal temperature >39.5 degrees C was observed in at most 3.2% of vaccinees. Swelling >50 mm occurred in 24% of DTPa-primed compared to 5.5% of DTPw-primed children. Large swelling involving the entire upper arm (extending to involve the elbow joint) was reported for up to 1.2% of DTPa-primed subjects, which is consistent with literature reports for other DTPa vaccines.
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