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Träfflista för sökning "WFRF:(Roca M) "

Search: WFRF:(Roca M)

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  • 2021
  • swepub:Mat__t
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  • 2021
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  • de Rojas, I., et al. (author)
  • Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
  • 2021
  • In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1
  • Journal article (peer-reviewed)abstract
    • Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer’s disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer’s disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer’s disease. © 2021, The Author(s).
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  • Abdo, A. A., et al. (author)
  • Multi-wavelength observations of the flaring gamma-ray blazar 3C 66A in 2008 October
  • 2011
  • In: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 726:1, s. 43-
  • Journal article (peer-reviewed)abstract
    • The BL Lacertae object 3C 66A was detected in a flaring state by the Fermi Large Area Telescope (LAT) and VERITAS in 2008 October. In addition to these gamma-ray observations, F-GAMMA, GASP-WEBT, PAIRITEL, MDM, ATOM, Swift, and Chandra provided radio to X-ray coverage. The available light curves show variability and, in particular, correlated flares are observed in the optical and Fermi-LAT gamma-ray band. The resulting spectral energy distribution can be well fitted using standard leptonic models with and without an external radiation field for inverse Compton scattering. It is found, however, that only the model with an external radiation field can accommodate the intra-night variability observed at optical wavelengths.
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  • Result 1-10 of 140
Type of publication
journal article (126)
conference paper (6)
research review (3)
book chapter (3)
Type of content
peer-reviewed (127)
other academic/artistic (9)
pop. science, debate, etc. (2)
Author/Editor
Roca, J (43)
Rodriguez-Martinez, ... (30)
Tegner, J (11)
Costantini, H. (10)
Junker, M. (9)
Imbriani, G. (9)
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Straniero, O. (9)
Vomiero, Alberto (9)
Romano, M. (8)
Naumann-Godo, M. (8)
Rostovtsev, A. (7)
Kooijman, P. (7)
Aguilar, J. A. (7)
Kappes, A. (7)
Karg, T. (7)
Montaruli, T. (7)
Anton, G. (7)
Katz, U. (7)
Brunner, J. (7)
Albert, A. (7)
Cuneo, S. (7)
Becherini, Yvonne (7)
Carr, J. (7)
Zaborov, D. (7)
Vallage, B. (7)
Feinstein, F. (7)
Carmona, E. (7)
Giacomelli, G. (7)
Margiotta, A. (7)
Popa, V. (7)
Spurio, M. (7)
Olivetto, C. (7)
de, Botton N (7)
van, Dantzig R (7)
Anghinolfi, M. (7)
Anvar, S. (7)
Aubert, J-J. (7)
Basa, S. (7)
Bertin, V. (7)
Bouwhuis, M. C. (7)
Circella, M. (7)
Coyle, P. (7)
Deschamps, A. (7)
Hallewell, G. (7)
Hello, Y. (7)
Hernandez-Rey, J. J. (7)
de Jong, M. (7)
Kouchner, A. (7)
Lo Presti, D. (7)
Loucatos, S. (7)
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Karolinska Institutet (58)
Linköping University (36)
Lund University (24)
Uppsala University (14)
University of Gothenburg (10)
Luleå University of Technology (10)
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Swedish University of Agricultural Sciences (9)
Stockholm University (7)
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Södertörn University (4)
Mid Sweden University (3)
Högskolan Dalarna (3)
Kristianstad University College (2)
Umeå University (2)
Örebro University (2)
Chalmers University of Technology (2)
Swedish Museum of Natural History (2)
Jönköping University (1)
Marie Cederschiöld högskola (1)
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Language
English (140)
Research subject (UKÄ/SCB)
Natural sciences (42)
Medical and Health Sciences (36)
Engineering and Technology (8)
Agricultural Sciences (6)
Humanities (2)
Social Sciences (1)

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