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- Batista, N, et al.
(author)
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Phase II study of capecitabine in combination with paclitaxel in patients with anthracycline-pretreated advanced/metastatic breast cancer.
- 2004
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In: Br J Cancer. - 0007-0920. ; 90:9, s. 1740-6
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Journal article (peer-reviewed)abstract
- The addition of oral capecitabine to docetaxel improves response rate, time to progression (TTP) and overall survival in anthracycline-pretreated metastatic breast cancer (MBC). This phase II study evaluates the efficacy and safety of a 21-day cycle of oral capecitabine (1000 mg m(-2) twice daily, days 1-14) plus i.v. paclitaxel (175 mg m(-2), day 1) in anthracycline-pretreated advanced/MBC. In all, 73 patients were enrolled at 13 Swedish and Spanish centres. The objective response rate was 52% (95% confidence interval (CI): 40-63%) in the intent-to-treat population, including complete responses in 11%. Disease was stabilised in a further 29%. The median time to disease progression (TTP) was 8.1 months and the median overall survival was 16.5 months. The combination was generally well tolerated with a predictable safety profile. The most common treatment-related nonhaematological adverse events were hand-foot syndrome (42%), alopecia (30%) and diarrhoea (26%). The only treatment-related Grade 3/4 adverse events occurring in >5% of patients were alopecia (22%) and hand-foot syndrome (11%). Grade 3/4 neutropenia and lymphocytopenia were reported in 12 and 14% of patients, respectively. Capecitabine plus paclitaxel is highly active with a favourable safety profile in anthracycline-pretreated MBC.
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- Rask, Eva, 1958-, et al.
(author)
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Impaired incretin response after a mixed meal is associated with insulin resistance in nondiabetic men
- 2001
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In: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 24:9, s. 1640-1645
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Journal article (peer-reviewed)abstract
- OBJECTIVE:To investigate whether features of the insulin resistance syndrome are associated with altered incretin responses to food intake.RESEARCH DESIGN AND METHODS:From a population-based study, 35 men were recruited, representing a wide spectrum of insulin sensitivity and body weight. Each subject underwent a hyperinsulinemic-euglycemic clamp to determine insulin sensitivity. A mixed meal was given, and plasma levels of gastric inhibitory polypeptide (GIP) and glucagon-like peptide 1 (GLP-1), as well as insulin, glucagon, and glucose were measured.RESULTS:Insulin resistance was associated with impaired GIP and GLP-1 responses to a mixed meal. The total area under the curve (AUC) of the GIP response after the mixed meal was associated with insulin sensitivity (r = 0.54, P < 0.01). There was a significant difference between the highest and the lowest tertile of insulin sensitivity (P < 0.05). GLP-1 levels 15 min after food intake were significantly lower in the most insulin-resistant tertile compared with the most insulin-sensitive tertile. During the first hour, the AUC of GLP-1 correlated significantly with insulin sensitivity (r = 0.47, P < 0.01). Multiple linear regression analysis showed that insulin resistance, but not obesity, was an independent predictor of these decreased incretin responses.CONCLUSIONS:In insulin resistance, the GIP and GLP-1 responses to a mixed meal are impaired and are related to the degree of insulin resistance. Decreased incretin responsiveness may be of importance for the development of impaired glucose tolerance.
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- Somsak, Dangtip, et al.
(author)
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Facility for measurements of nuclear cross sections for fast neutron cancer therapy
- 2000
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In: Nuclear Instruments and Methods in Physics Research Section A. - 0168-9002 .- 1872-9576. ; 452:3, s. 484-504
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Journal article (peer-reviewed)abstract
- A facility for measurements of neutron-induced double-differential light-ion production cross-sections, for application within, e.g., fast neutron cancer therapy, is described. The central detection elements are three-detector telescopes consisting of two silicon detectors and a CsI crystal. Use of ?E-?E-E techniques allows good particle identification for p, d, t, 3He and alpha particles over an energy range from a few MeV up to 100 MeV. Active plastic scintillator collimators are used to define the telescope solid angle. Measurements can be performed using up to eight telescopes at 20░ intervals simultaneously, thus covering a wide angular range. The performance of the equipment is illustrated using experimental data taken with a carbon target at En = 95 MeV. Distortions of the measured charged-particle spectra due to energy and particle losses in the target are corrected using a newly developed computer code. Results from such correction calculations are presented.
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