| 1. |
- Naredi, Peter, 1955, et al.
(author)
-
The influence of hepatic artery ligation and of vasopressin on liver tumour blood flow in rats.
- 1992
-
In: Journal of surgical oncology. - : Wiley. - 0022-4790 .- 1096-9098. ; 50:2, s. 70-6
-
Journal article (peer-reviewed)abstract
- The blood flow in an experimental adenocarcinoma in the rat liver was determined with the 133Xe-washout technique before and after hepatic artery ligation (HAL). There was an initial reduction of the washout of 50%. This was further reduced after 1 day by 50%, which was maintained for 7 days. Seven days after HAL or sham procedures the 133Xe-washout was of similar magnitude in the liver tumours, although after the sham procedure the tumours were larger (3.4 g vs. 1.5 g). The estimated tumour blood flow was then approximately 0.04 ml x min-1 x g-1. The influence on normal liver parenchyma of HAL was a reduction at 30 minutes, which was maintained for 7 days. Postacton--a synthetic vasopressin--did not influence the 133Xe-washout in normal liver parenchyma in non-tumour, as well as in tumour-bearing animals. There was no influence of Postacton on the 133Xe-washout in the liver tumours. Thirty minutes after HAL Postacton gave a reduction of blood flow in normal liver parenchyma of tumour-bearing animals, which is thus only from the portal vein. In tumours Postacton did not significantly reduce the tumour blood flow immediately after HAL.
|
|
| 2. |
- Gislén, Lars, et al.
(author)
-
Complex Scheduling with Potts Neural Networks
- 1992
-
In: Neural Computation. - : MIT Press - Journals. - 1530-888X .- 0899-7667. ; 4:6, s. 805-831
-
Journal article (peer-reviewed)abstract
- In a recent paper (Gislén et al. 1989) a convenient encoding and an efficient mean field algorithm for solving scheduling problems using a Potts neural network was developed and numerically explored on simplified and synthetic problems. In this work the approach is extended to realistic applications both with respect to problem complexity and size. This extension requires among other things the interaction of Potts neurons with different number of components. We analyze the corresponding linearized mean field equations with respect to estimating the phase transition temperature. Also a brief comparison with the linear programming approach is given. Testbeds consisting of generated problems within the Swedish high school system are solved efficiently with high quality solutions as results.
|
|
| 3. |
- Gislén, Lars, et al.
(author)
-
Rotor Neurons: Basic Formalism and Dynamics
- 1992
-
In: Neural Computation. - : MIT Press - Journals. - 1530-888X .- 0899-7667. ; 4:5, s. 737-745
-
Journal article (peer-reviewed)abstract
- Rotor neurons are introduced to encode states living on the surface of a sphere in D dimensions. Such rotors can be regarded as continuous generalizations of binary (Ising) neurons. The corresponding mean field equations are derived, and phase transition properties based on linearized dynamics are given. The power of this approach is illustrated with an optimization problem—placing N identical charges on a sphere such that the overall repulsive energy is minimized. The rotor approach appears superior to other methods for this problem both with respect to solution quality and computational effort needed.
|
|
| 4. |
- Sorbe, Bengt, et al.
(author)
-
Tropisetron (Navoban) in the prevention of chemotherapy-induced nausea and vomiting : the Nordic experience
- 1994
-
In: Supportive Care in Cancer. - 0941-4355 .- 1433-7339. ; 2:6, s. 393-399
-
Journal article (peer-reviewed)abstract
- An open, noncomparative, Nordic multicenter study was carried out during 1991-1992 to evaluate the 5-HT3 receptor antagonist tropisetron (Navoban) as an antiemetic agent for various types of cancer chemotherapy. A total of 630 patients were recruited from 15 centers in Sweden, Denmark, and Finland. Gynecological cancers (60%), breast cancer (15%), and lung cancer (10%) were the main diagnoses. Prior experience of chemotherapy was documented in 338 patients (54%). In 260 patients (41%), cisplatin was part of the cytostatic regimen. Carboplatin (23%), doxorubicin (27%), and epidoxorubicin (24%) were also frequently included. In all, 23 cytostatic agents were used in various combinations. The mean number of courses studied was 4.6 (range 1-19). Altogether, 394 of 619 evaluable patients (64%) were completely protected from acute nausea and vomiting during the first course of chemotherapy. Delayed nausea and vomiting were completely prevented in 45%-73% (days 2-6) in the complete series. Treatment efficacy remained stable (60%-79%) during ten consecutive courses of chemotherapy. With noncisplatin regimens, complete protection from acute nausea and vomiting was achieved in 72% compared with 52% for cisplatin regimens (P < 0.0001). Patients without prior experience of chemotherapy had higher control rates of acute nausea and vomiting (72%) compared to patients treated before (57%) during the first course, but not later on. There were no differences in delayed nausea and vomiting.
|
|
