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Träfflista för sökning "WFRF:(SJOGREN S) srt2:(2005-2009)"

Search: WFRF:(SJOGREN S) > (2005-2009)

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  • Strom, L, et al. (author)
  • Postreplicative formation of cohesion is required for repair and induced by a single DNA break
  • 2007
  • In: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 317:5835, s. 242-245
  • Journal article (peer-reviewed)abstract
    • Sister-chromatid cohesion, established during replication by the protein complex cohesin, is essential for both chromosome segregation and double-strand break (DSB) repair. Normally, cohesion formation is strictly limited to the S phase of the cell cycle, but DSBs can trigger cohesion also after DNA replication has been completed. The function of this damage-induced cohesion remains unknown. In this investigation, we show that damage-induced cohesion is essential for repair in postreplicative cells in yeast. Furthermore, it is established genome-wide after induction of a single DSB, and it is controlled by the DNA damage response and cohesin-regulating factors. We thus define a cohesion establishment pathway that is independent of DNA duplication and acts together with cohesion formed during replication in sister chromatid–based DSB repair.
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  • Result 1-9 of 9

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