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Träfflista för sökning "WFRF:(Sakata K) srt2:(1996-1999)"

Search: WFRF:(Sakata K) > (1996-1999)

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1.
  • Drake, M., et al. (author)
  • The immunosuppressant FK506 ameliorates ischaemic damage in the rat brain
  • 1996
  • In: Acta Physiologica Scandinavica. - 0001-6772. ; 158:2, s. 155-159
  • Journal article (peer-reviewed)abstract
    • The effect of the immunosuppressant FK506 on ischaemic neuronal damage was studied in a rat model of transient cerebral ischemia induced by occlusion of both common carotid arteries in combination with hypotension for 10 min. Neuronal damage was assessed morphologically after 4 days of recovery. Treatment with FK506, given at a dose of 2 mg kg-1 by intraperitoneal injections 30 min prior to ischemia and once daily during recovery, decreased neuronal damage by 52% in the hippocampal CA1 region and by 48% in the temporal cortex. The protection was not due to diminished body temperature or a marked reduction of ischaemia-induced synaptic overflow of glutamate. We propose that FK506 decreases neuronal damage either by inhibiting calcineurin-mediated events or by preserving mitochondrial function.
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  • Result 1-2 of 2
Type of publication
journal article (2)
Type of content
peer-reviewed (2)
Author/Editor
Wieloch, T. (3)
Sakata, K (2)
Drake, M (1)
Friberg, H. (1)
Siesjo, BK (1)
Cardell, M (1)
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Boris-Möller, F. (1)
Kamme, F (1)
Kurihara, J (1)
Hu, BR (1)
BorisMoller, A (1)
Boris-Möller, A. (1)
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University
Lund University (2)
Karolinska Institutet (1)
Language
English (2)
Research subject (UKÄ/SCB)
Medical and Health Sciences (2)
Year
1996 (2)

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