| 1. |
- Al-Karadaghi, Salam, et al.
(author)
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Chelatases: distort to select?
- 2006
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In: Trends in Biochemical Sciences. - : Elsevier BV. - 0167-7640 .- 0968-0004. ; 31:3, s. 135-142
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Journal article (other academic/artistic)abstract
- Chelatases catalyze the insertion of a specific metal ion into porphyrins, a key step in the synthesis of metalated tetrapyrroles that are essential for many cellular processes. Despite apparent common structural features among chelatases, no general reaction mechanism accounting for metal ion specificity has been established. We propose that chelatase-induced distortion of the porphyrin substrate not only enhances the reaction rate by decreasing the activation energy of the reaction but also modulates which divalent metal ion is incorporated into the porphyrin ring. We evaluate the recently recognized interaction between ferrochelatase and frataxin as a way to regulate iron delivery to ferrochelatase, and thus iron and heme metabolism. We postulate that the ferrochelatase-frataxin interaction controls the type of metal ion that is delivered to ferrochelatase.
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| 2. |
- Jung, Hannes, et al.
(author)
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What HERA may provide?
- 2008
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In: Proceedings, 16th International Workshop on Deep Inelastic Scattering and Related Subjects (DIS 2008): London, UK, April 7-11, 2008. - Amsterdam : Science Wise Publishing. ; , s. 17-17
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Conference paper (other academic/artistic)
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| 3. |
- Norrman, Mathias, et al.
(author)
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Characterization of insulin microcrystals using powder diffraction and multivariate data analysis
- 2006
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In: Journal of Applied Crystallography. - 1600-5767. ; 39, s. 391-400
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Journal article (peer-reviewed)abstract
- Twelve different microcrystalline insulin formulations were investigated by X-ray powder diffraction and were shown to have very characteristic patterns. Three of the formulations crystallize in the same crystal system, but have structural differences in the N-terminal B-chain of the insulin molecule. This difference was efficiently detected in the powder patterns. The sensitivity of the method makes it a valuable tool for characterization of microcrystalline samples. By use of principal-component analysis, the twelve different formulations originating from six different crystal systems were classified into nine separate clusters. The powder patterns of each cluster can now be used as `fingerprints' for the different insulin polymorphs. The combination of X-ray powder diffraction and multivariate analysis, such as principal-component analysis, provides a rapid and effective tool for studying the influence of derivatives, additives, ions, pH etc., in the crystallization media.
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| 4. |
- Qadri, F., et al.
(author)
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Enterotoxigenic Escherichia coli and Vibrio cholerae diarrhea, Bangladesh, 2004
- 2005
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In: Emerg Infect Dis. ; 11:7, s. 1104-7
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Journal article (peer-reviewed)abstract
- Flooding in Dhaka in July 2004 caused epidemics of diarrhea. Enterotoxigenic Escherichia coli (ETEC) was almost as prevalent as Vibrio cholerae O1 in diarrheal stools. ETEC that produced heat-stable enterotoxin alone was most prevalent, and 78% of strains had colonization factors. Like V. cholerae O1, ETEC can cause epidemic diarrhea.
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