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Träfflista för sökning "WFRF:(Samen E) srt2:(2010-2014)"

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1.	Arnberg, F, et al. (author) Selective intra-arterial administration of ¹⁸F-FDG to the rat brain -- effects on hemispheric uptake 2014 In: Neuroradiology. - : Springer Science and Business Media LLC. - 1432-1920 .- 0028-3940. ; 56:5, s. 375-380 Journal article (peer-reviewed)
2.	Cheng, Q, et al. (author) Site-specifically 11C-labeled Sel-tagged annexin A5 and a size-matched control for dynamic in vivo PET imaging of protein distribution in tissues prior to and after induced cell death 2013 In: Biochimica et biophysica acta. - : Elsevier BV. - 0006-3002 .- 0304-4165. ; 1830:3, s. 2562-2573 Journal article (peer-reviewed)
3.	Hagberg, Carolina E, et al. (author) Vascular endothelial growth factor B controls endothelial fatty acid uptake. 2010 In: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 464:7290, s. 917-21 Journal article (peer-reviewed)abstract The vascular endothelial growth factors (VEGFs) are major angiogenic regulators and are involved in several aspects of endothelial cell physiology. However, the detailed role of VEGF-B in blood vessel function has remained unclear. Here we show that VEGF-B has an unexpected role in endothelial targeting of lipids to peripheral tissues. Dietary lipids present in circulation have to be transported through the vascular endothelium to be metabolized by tissue cells, a mechanism that is poorly understood. Bioinformatic analysis showed that Vegfb was tightly co-expressed with nuclear-encoded mitochondrial genes across a large variety of physiological conditions in mice, pointing to a role for VEGF-B in metabolism. VEGF-B specifically controlled endothelial uptake of fatty acids via transcriptional regulation of vascular fatty acid transport proteins. As a consequence, Vegfb(-/-) mice showed less uptake and accumulation of lipids in muscle, heart and brown adipose tissue, and instead shunted lipids to white adipose tissue. This regulation was mediated by VEGF receptor 1 and neuropilin 1 expressed by the endothelium. The co-expression of VEGF-B and mitochondrial proteins introduces a novel regulatory mechanism, whereby endothelial lipid uptake and mitochondrial lipid use are tightly coordinated. The involvement of VEGF-B in lipid uptake may open up the possibility for novel strategies to modulate pathological lipid accumulation in diabetes, obesity and cardiovascular diseases.
4.	Hagberg, CE, et al. (author) Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes 2012 In: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 490:7420, s. 426- Journal article (peer-reviewed)
5.	Samen, E, et al. (author) Metabolism of epidermal growth factor receptor targeting probe [11C]PD153035: impact on biodistribution and tumor uptake in rats 2013 In: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. - : Society of Nuclear Medicine. - 1535-5667. ; 54:10, s. 1804-1811 Journal article (peer-reviewed)
6.	Samen, E, et al. (author) Visualization of angiogenesis during cancer development in the polyoma middle T breast cancer model: molecular imaging with (R)-[11C]PAQ 2014 In: EJNMMI research. - 2191-219X. ; 4:1, s. 17- Journal article (peer-reviewed)

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Result 1-6 of 6

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Type of publication: journal article (6)

Type of content: peer-reviewed (6)

Author/Editor: Lu, L. (5); Stone-Elander, S (5); Samen, E (5); Thorell, JO (3); Tegnebratt, T. (2); Holmin, S. (2); show more...; Arnberg, F (2); Grafstrom, J (2); Olofsson, MH (2); Lundberg, J. (1); Claesson-Welsh, Lena (1); Eriksson, U (1); Johansson, K (1); Damberg, P (1); Mulder, J (1); Hagberg, CE (1); Hagberg, Carolina E. (1); Andrikopoulos, S (1); Soderman, M (1); Nilsson, Ingrid (1); Rundqvist, H (1); Larsson, Erik, 1975 (1); Linder, S (1); Falkevall, A (1); Klar, Joakim (1); Ortsater, H (1); Sjoholm, A (1); Pietras, Kristian (1); Huusko, Jenni (1); Cheng, Q (1); Arnér, ESJ (1); Holmgren, L (1); Eriksson, Ulf (1); Genove, Guillem (1); Muhl, L (1); Lu, Li (1); Lindahl, Per, 1967 (1); Ylä-Herttuala, Seppo (1); Stone-Elander, Sharo ... (1); Ahlzen, HS (1); van Meeteren, Lauren ... (1); Nyqvist, D (1); Falkevall, Annelie (1); Mehlem, A (1); Scotney, P (1); Nash, A (1); Wang, Xun (1); Samen, Erik (1); Vanwildemeersch, Maa ... (1); Fam, BC (1); show less...

University: Karolinska Institutet (6); University of Gothenburg (1); Uppsala University (1)

Language: English (6)

Research subject (UKÄ/SCB): Medical and Health Sciences (2); Natural sciences (1)

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