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- Nilsson-Ehle, Herman, et al.
(author)
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Quality of life, physical function and MRI T2*in elderly low-risk MDS patients treated to a haemoglobin level of andgt;= 120 g/L with darbepoetin alfa +/- filgrastim or erythrocyte transfusions
- 2011
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In: European Journal of Haematology. - : John Wiley and Sons. - 0902-4441 .- 1600-0609. ; 87:3, s. 244-252
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Journal article (peer-reviewed)abstract
- Objective: Anaemia in low-risk myelodysplastic syndromes (MDS) is associated with reduced quality of life (QoL). Response to treatment with erythropoietin +/- granulocyte colony-stimulating factor (G-CSF) is associated with improved QoL, but whether transfusion therapy with higher haemoglobin (Hb) target levels has similar effects is unknown. The objective for this prospective phase II Nordic multicentre trial was to assess QoL, response rate and physical function in elderly anaemic MDS patients treated to a target Hb level of andgt; 120 g /L. Methods: Thirty-six elderly patients with low-and intermediate-1 risk MDS received darbepoetin (DA) 300 mu g/wk, with the addition of G-CSF if no response. If the Hb target was reached at 16 wk, treatment was maintained until week 26. Remaining patients were transfused to reach the target level for at least 8 wk. Results: Twenty-seven patients completed the study. Response rate to DA +/- G-CSF was 67% in evaluable patients and 56% according to intention to treat. Eighteen patients reached the target Hb level according to protocol. QoL scores for fatigue, dyspnoea, constipation, and physical, role and social functioning improved significantly during study, with similar results for transfused and untransfused patients. Maintaining Hb andgt; 120 g /L did not confer a higher transfusion rate, once the target was reached. In two of fourteen patients, magnetic resonance imaging T2* indicated cardiac iron overload, however, without association with ferritin levels. Conclusions: In elderly anaemic MDS patients, an increment in haemoglobin is associated with improved QoL, whether induced by growth factor treatment or transfusion therapy.
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- Andersson-Roswall, Lena, 1965, et al.
(author)
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Cognitive outcome 10 years after temporal lobe epilepsy surgery: a prospective controlled study
- 2010
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In: Neurology. - 0028-3878. ; 74:24, s. 1977-1985
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Journal article (peer-reviewed)abstract
- Objective: To explore late effects of temporal lobe resection (TLR) for epilepsy on general cognitive level and memory. Methods: Fifty-one patients who had undergone TLR (23 in the speech-dominant temporal lobe [DTL] and 28 in the nondominant temporal lobe [NDTL]) were assessed preoperatively and 2 and 10 years postoperatively. Twenty-three healthy controls were assessed at baseline and at corresponding intervals. A battery of standardized tests for assessment of general cognitive level and memory was analyzed using a linear mixed model of between-subjects treatment effect and within-subject time effect. Results: The main result was cognitive stability from 2 to 10 years after TLR. The DTL group had declined in verbal memory at the 10-year follow-up compared to the NDTL group and to the controls. However, this decline was detected already 2 years postoperatively, with no further decline from 2 to 10 years. The memory decline was not related to seizure outcome or AED treatment. The NDTL group showed less improvement in performance IQ (PIQ) at the 10-year follow-up compared to the controls. The most important correlate to inferior PIQ scores was continuing seizures, which was more frequent in the NDTL group. Conclusions: In this study, the main finding was cognitive stability from 2 to 10 years after temporal lobe resection. There was no further decline in verbal memory from 2 to 10 years after surgery, lending no support to the notion of an ongoing progressive decline in verbal memory after temporal lobe resection. The verbal memory course was not dependent on seizure outcome or antiepileptic drug treatment.
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- Andersson-Roswall, Lena, 1965, et al.
(author)
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Verbal memory decline is less frequent at 10 years than at 2 years after temporal lobe surgery for epilepsy
- 2012
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In: Epilepsy & Behavior. - : Elsevier BV. - 1525-5050. ; 24:4, s. 462-467
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Journal article (peer-reviewed)abstract
- We investigated individual short-and long-term verbal memory changes after temporal lobe resection for epilepsy. Fifty-one patients (23 operated on the speech-dominant temporal lobe, DTL and 28 on the non-dominant temporal lobe, NDTL) were tested on learning/immediate recall and delayed recall of word-list and word-pairs preoperatively, 2 years postoperatively and 10 years postoperatively. Changes were defined using reliable change indices of 23 healthy controls assessed at corresponding intervals. Fewer patients had reliable declines at 10 years than at 2 years (DTL: 13-35% vs 35-44%; NDTL: 0-4% vs 7-21%). Four DTL patients (17%) had reliable declines in >= 2 tests at 10-year follow-up. More NDTL patients had improvement at 10 years than at 2 years (18-30% vs 4-22%). The only risk factor for decline both short and long term was DTL resection. In conclusion, most patients had stable verbal memory postoperatively. A few DTL patients had a lasting decline at long-term follow-up, but more patients showed partial recovery, especially in the NDTL group. (C) 2012 Elsevier Inc. All rights reserved.
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- Asproth, Viveca, et al.
(author)
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E-tjänstens framtida historia : Informationsbevarande, ett bortglömt ansvarsområde?
- 2010. - 1:1
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In: Förvaltning och medborgarskap i förändring. - Lund : Studentlitteratur. - 9789144055626 ; , s. 167-184
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Book chapter (other academic/artistic)abstract
- Innehåll: Inledning, Svensk offentlighetslagstriftning, Den komplexa och integrerade e-tjänsten - bakgrund och definition, Problemområden, Ansvarsfrågan, Informationens kvalitet över tid, Andvändaren / medborgaren, rekommendationer, Proaktivitet, Avslutning.
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- Björklund Boistrup, Lisa, et al.
(author)
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Elever som skriver och ingriper : Aktionsforskning om bedömning i matematik
- 2013
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Reports (other academic/artistic)abstract
- "Jag har lärt mig att man kan räkna ut tal på tallinjen och multiplikationstabellerna kan jag bättre nu. Jag behöver träna lite mer på 7, 8, 9:ans tabeller för ibland fastnar jag på de tabellerna och jag kan alla tabellerna bra men måste också träna på dom fast mest de andra. Jag tycker att det har fungerat bra denna vecka för jag har lärt mig mycket och nya räknesätt som går snabbare att räkna ibland."Så här reflekterar en elev om vad hon/han har lärt sig i matematik under den gångna veckan och också vad eleven behöver träna mer på samt vad som har fungerat bra. Eleven skrev detta i en logg som läraren tog initiativ till. Som kommer att framgå av denna rapport har eleverna i detta projekt fått olika möjligheter att skriva i matematik och även att vara med och bli mer delaktiga i sina lärandeprocesser och i undervisningen. Långsiktigt handlar detta om ett förändringsarbete mot positivt förändrade traditioner i matematikundervisningen.
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- Bratt, Ewa-Lena, 1970, et al.
(author)
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New kid on the block? Community nurses' experiences of caring for sick children at home
- 2014
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In: American Academy of Nursing 2014 Transforming Health, Driving Policy Conference held from October 16 - 18 2014. Washington, USA.
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Conference paper (other academic/artistic)abstract
- Aim: To investigate the experiences of community nurses regarding caring for sick children at home, since this is a growing population of patients in community care, and most community nurses do not have an extensive experience in caring for sick children. Methods: Using a qualitative, descriptive design, in-depth interviews were conducted with twelve nurses working in community healthcare in Sweden. Qualitative content analysis was used. Results: “To feel confident in order to create confidence” was key in nurses’ experiences. Two main themes emerged: ”to build a trusting relationship with the family" and "to feel confident in the role as caregivers". Nurses aimed at creating a trusting nursing relationship and working closely with parents. The feeling of confidence in their role as caregivers depended of the support that nurses received and the knowledge that they have. Six subthemes emerged: “the importance of adequate knowledge”; “to handle the emotional reactions”; “need for support and guidance”; “collaborating with family”; “thoroughly planned visits”; and “communicating with the whole family”. Conclusion: Many community nurses felt insecure to care for children at home. However, they experienced this as manageable when receiving peer support and when there is a distinct collaboration with the pediatric clinic/hospital. A need for guidance and education was expressed. Policy implications: The ongoing shift from hospital to home urges pediatric clinics/hospitals and community healthcare to develop formal policies of transmural collaboration to train and support home nurses for delivering adequate care to sick children and their families at home, and safeguard good outcomes.
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| 10. |
- Ek, Lena, 1961-
(author)
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Cognitive Deficits Reflecting Diffuse and Focal Brain Lesions Caused by Slow Growing Brain Tumors - Low-grade Gliomas
- 2010
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Doctoral thesis (other academic/artistic)abstract
- The overall purpose was to characterize the impact that low-grade glioma (LGG) – a type of slowly growing brain tumor – has on cognitive functions. Paper I was an in-depth analysis of cognitive dysfunction of patients with histological proven LGG. The pattern varied among patients, revealing three subgroups: 1) patients with severe cognitive dysfunction; 2) patients with mild cognitive dysfunction; 3) patients with selective dysfunction due to tumor localization. In the first two subgroups the patients had slowed information-processing speed. Patients with a favorable prognosis performed better than those with unfavorable prognosis. Nonworking patients showed more pronounced dysfunction than working patients. Paper II studied cognitive functions of patients who were in the early stage of the disease and had not yet received any major medical treatments. Patients’ performances ranked at the lower end of normal limits, which contrasted with those of the individually matched controls, whose performances ranked at the upper end. Patients had slower information-processing-speed and less effective executive functions. Patients with frontal tumors had various executive problems due to tumor localization. Paper III investigated cognitive impairment at the individual level in relation to neurological symptoms, radiological characteristics of the tumor, depression, and fatigue. Paper III included the same patients as Paper II. The results showed that the majority of the patients did not have more than selective impairment. One subgroup, consisting of younger patients with large left frontal tumors showed obvious cognitive impairment, including slowed information-processing speed. The thesis showed that diffuse brain injury was closely connected to LGG. A subgroup of patients in the early phase of the disease showed signs of mild diffuse brain injury. The majority of the patients who were in later stage of the disease displayed cognitive signs of diffuse brain injury.
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