SwePub
Sök i SwePub databas

  Extended search

Träfflista för sökning "WFRF:(Sandberg A) srt2:(2020-2024)"

Search: WFRF:(Sandberg A) > (2020-2024)

  • Result 1-10 of 80
Sort/group result
   
EnumerationReferenceCoverFind
1.
  • Callaway, EM, et al. (author)
  • A multimodal cell census and atlas of the mammalian primary motor cortex
  • 2021
  • In: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 598:7879, s. 86-102
  • Journal article (peer-reviewed)abstract
    • Here we report the generation of a multimodal cell census and atlas of the mammalian primary motor cortex as the initial product of the BRAIN Initiative Cell Census Network (BICCN). This was achieved by coordinated large-scale analyses of single-cell transcriptomes, chromatin accessibility, DNA methylomes, spatially resolved single-cell transcriptomes, morphological and electrophysiological properties and cellular resolution input–output mapping, integrated through cross-modal computational analysis. Our results advance the collective knowledge and understanding of brain cell-type organization1–5. First, our study reveals a unified molecular genetic landscape of cortical cell types that integrates their transcriptome, open chromatin and DNA methylation maps. Second, cross-species analysis achieves a consensus taxonomy of transcriptomic types and their hierarchical organization that is conserved from mouse to marmoset and human. Third, in situ single-cell transcriptomics provides a spatially resolved cell-type atlas of the motor cortex. Fourth, cross-modal analysis provides compelling evidence for the transcriptomic, epigenomic and gene regulatory basis of neuronal phenotypes such as their physiological and anatomical properties, demonstrating the biological validity and genomic underpinning of neuron types. We further present an extensive genetic toolset for targeting glutamatergic neuron types towards linking their molecular and developmental identity to their circuit function. Together, our results establish a unifying and mechanistic framework of neuronal cell-type organization that integrates multi-layered molecular genetic and spatial information with multi-faceted phenotypic properties.
  •  
2.
  •  
3.
  •  
4.
  •  
5.
  • Gao, Y, et al. (author)
  • Ancestral SARS-CoV-2-specific T cells cross-recognize the Omicron variant
  • 2022
  • In: Nature medicine. - : Springer Science and Business Media LLC. - 1546-170X .- 1078-8956. ; 28:3, s. 472-
  • Journal article (peer-reviewed)abstract
    • The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron (B.1.1.529) variant of concern (VOC) has destabilized global efforts to control the impact of coronavirus disease 2019 (COVID-19). Recent data have suggested that B.1.1.529 can readily infect people with naturally acquired or vaccine-induced immunity, facilitated in some cases by viral escape from antibodies that neutralize ancestral SARS-CoV-2. However, severe disease appears to be relatively uncommon in such individuals, highlighting a potential role for other components of the adaptive immune system. We report here that SARS-CoV-2 spike-specific CD4+ and CD8+ T cells induced by prior infection or BNT162b2 vaccination provide extensive immune coverage against B.1.1.529. The median relative frequencies of SARS-CoV-2 spike-specific CD4+ T cells that cross-recognized B.1.1.529 in previously infected or BNT162b2-vaccinated individuals were 84% and 91%, respectively, and the corresponding median relative frequencies for SARS-CoV-2 spike-specific CD8+ T cells were 70% and 92%, respectively. Pairwise comparisons across groups further revealed that SARS-CoV-2 spike-reactive CD4+ and CD8+ T cells were functionally and phenotypically similar in response to the ancestral strain or B.1.1.529. Collectively, our data indicate that established SARS-CoV-2 spike-specific CD4+ and CD8+ T cell responses, especially after BNT162b2 vaccination, remain largely intact against B.1.1.529.
  •  
6.
  •  
7.
  •  
8.
  •  
9.
  •  
10.
  •  
Skapa referenser, mejla, bekava och länka
  • Result 1-10 of 80
Type of publication
journal article (70)
conference paper (7)
doctoral thesis (2)
book chapter (1)
Type of content
peer-reviewed (69)
other academic/artistic (10)
pop. science, debate, etc. (1)
Author/Editor
Sandberg, JK (25)
Buggert, M (16)
Ljunggren, HG (15)
Aleman, S (14)
Sandberg, R (10)
Rooyackers, O (9)
show more...
Sekine, T (8)
Bjorkstrom, NK (8)
Stralin, K (8)
Gao, Y. (7)
Eriksson, LI (7)
Bergman, P. (7)
Price, DA (7)
Klingstrom, J (7)
Ziegenhain, C (7)
Norrby-Teglund, A (6)
Muvva, JR (6)
Grifoni, A (5)
Sette, A (5)
Llewellyn-Lacey, S (5)
Svensson, M. (4)
Sandberg, M (4)
Olsson, A (4)
Lourda, M (4)
Chambers, BJ (4)
Malmberg, KJ (4)
Garcia, M (4)
Chen, P (3)
Osterborg, A (3)
Hansson, L (3)
Abdollahpur, Mostafa (3)
Sandberg, Frida (3)
Seki, M (3)
Michaelsson, J (3)
Adamo, S (3)
Muller, TR (3)
Markljung, E (3)
Axmon, A. (3)
Nordenstrom, A (3)
Lehander, M (3)
Hillen, A (3)
Mazzi, S (3)
Jacobsen, SEW (3)
Mjosberg, J (3)
Sandberg, A. (3)
Pernemalm, M (3)
Carrelha, J (3)
Parekh, S (3)
Han, F. (3)
Strunz, B (3)
show less...
University
Karolinska Institutet (57)
Lund University (12)
University of Gothenburg (6)
Royal Institute of Technology (6)
Umeå University (5)
Uppsala University (4)
show more...
Chalmers University of Technology (3)
Linköping University (2)
Luleå University of Technology (1)
Stockholm University (1)
Mälardalen University (1)
Örebro University (1)
show less...
Language
English (79)
Swedish (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (18)
Natural sciences (11)
Engineering and Technology (2)
Agricultural Sciences (2)
Social Sciences (2)

Year

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view