| 1. |
- Adler, SS, et al.
(author)
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Double helicity asymmetry in inclusive midrapidity pi(0) production for polarized p+p collisions at root s=200 GeV
- 2004
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In: Physical Review Letters. - 1079-7114. ; 93:20: 202002
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Journal article (peer-reviewed)abstract
- We present a measurement of the double longitudinal spin asymmetry in inclusive pi(0) production in polarized proton-proton collisions at roots=200 GeV. The data were taken at the Relativistic Heavy Ion Collider with average beam polarizations of 0.27. The measurements are the first in a program to study the longitudinal spin structure of the proton, using strongly interacting probes, at collider energies. The asymmetry is presented for transverse momenta 1-5 GeV/c at midrapidity, where next-to-leading-order perturbative quantum chromodynamic (NLO pQCD) calculations well describe the unpolarized cross section. The observed asymmetry is small and is compared to a NLO pQCD calculation with a range of polarized gluon distributions.
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| 2. |
- Lewis, Cathryn M, et al.
(author)
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Genome scan meta-analysis of schizophrenia and bipolar disorder, part II : Schizophrenia
- 2003
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In: American Journal of Human Genetics. - 0002-9297 .- 1537-6605. ; 73:1, s. 34-48
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Journal article (peer-reviewed)abstract
- Schizophrenia is a common disorder with high heritability and a 10-fold increase in risk to siblings of probands. Replication has been inconsistent for reports of significant genetic linkage. To assess evidence for linkage across studies, rank-based genome scan meta-analysis (GSMA) was applied to data from 20 schizophrenia genome scans. Each marker for each scan was assigned to 1 of 120 30-cM bins, with the bins ranked by linkage scores (1 = most significant) and the ranks averaged across studies (R(avg)) and then weighted for sample size (N(sqrt)[affected casess]). A permutation test was used to compute the probability of observing, by chance, each bin's average rank (P(AvgRnk)) or of observing it for a bin with the same place (first, second, etc.) in the order of average ranks in each permutation (P(ord)). The GSMA produced significant genomewide evidence for linkage on chromosome 2q (PAvgRnk<.000417). Two aggregate criteria for linkage were also met (clusters of nominally significant P values that did not occur in 1,000 replicates of the entire data set with no linkage present): 12 consecutive bins with both P(AvgRnk) and P(ord)<.05, including regions of chromosomes 5q, 3p, 11q, 6p, 1q, 22q, 8p, 20q, and 14p, and 19 consecutive bins with P(ord)<.05, additionally including regions of chromosomes 16q, 18q, 10p, 15q, 6q, and 17q. There is greater consistency of linkage results across studies than has been previously recognized. The results suggest that some or all of these regions contain loci that increase susceptibility to schizophrenia in diverse populations.
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| 3. |
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| 4. |
- Ansal, A., et al.
(author)
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Seismic microzonation for earthquake risk mitigation in turkey
- 2004
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Conference paper (peer-reviewed)abstract
- As a tool to improve the state of land use management in Turkey and to better mitigate earthquake risk inthe future, a microzonation project was initiated after the 1999 Kocaeli earthquake. The project had twocomponents (a) drafting a microzonation manual [1], (b) conducting pilot case studies in the selected tworegions affected by the 1999 Marmara earthquakes [2]. The main purpose of the study was to test anddemonstrate the applicability of the methodology proposed in the Seismic Microzonation Manual preparedfor the project. The major contributions of the study are the probabilistic assessment of the regionalearthquake hazard, interpretation of the microtremor records, and interpretation of the available geologicaland geotechnical data based on a grid approach. All the available data was transformed to GIS format andthe results are evaluated to obtain a microzonation with respect to site amplification, liquefactionsusceptibility and landslide hazard. An attempt will be made to summarize the results of the pilot studyconducted for the Gölcük region to give an overview of the proposed methodology.
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| 5. |
- Ansal, A., et al.
(author)
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Site Characterization and Site Amplification for a Seismic Microzonation Study in Turkey
- 2004
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Conference paper (peer-reviewed)abstract
- The pilot areas were divided into cells by a grid system of 500 m x 500 m for estimating the effects of site conditions at a scale of 1:5000 by assigning representative soil profiles at the centre of each grid. These soil profiles were classified according to the Turkish Earthquake Code, NEHRP site classification, equivalent shear wave velocity and used for site response analyses. The zonation maps involve the division of the area into three zones as (A, B, and C). In all cases, the variations of the calculated parameters are considered separately and their frequency distributions were determined. Thus the zone A shows the most unsuitable 33 percentile, zone B the medium 34 percentile and zone C shows the most favorable 33 percentile. A suitable pa-rameter is considered to be the average spectral acceleration between 0.5-1.5 sec periods obtained from site response analysis. Even though more empirical, the spectral amplifi-cations calculated using equivalent shear wave velocities gave consistent values that appear to be realistic when compared with the selected soil profiles. Thus microzonation maps with respect to ground shaking were based on the average of spectral accelerations and spectral amplifications obtained from equivalent shear wave velocities.
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| 6. |
- Caprez, M., et al.
(author)
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Testing of TBM excavation material in sandstone and marl for reuse in embankments or as fill
- 2001
-
Conference paper (peer-reviewed)abstract
- Several tunnels in geological formations of molasse, marl or sandstone are planned or are presently under construction in Switzerland. The excavation of these tunnels is very often carried out by tunnel boring machines (TBM). This kind of excavation tends to produce lamellar excavation materials (chips). For the reuse of these materials in road embankments etc., there are certain disadvantages concerning the compression properties. Limiting deformation will be the main restriction on design in the reuse of this material and this is manifested also in terms of the possible changes of volume as a function of time. On the one hand, volume may increase due to instability in relation to water and possibly frost, whereby swelling occurs. On the other hand, volume may decrease due to repeated dynamic loading. Inevitably these volume changes will not occur to the same degree and within the same timeframe. The material can be stabilised by using a variety of cementing agents to improve the key properties. A range of laboratory experiments were performed to find the optimal mixture to be used as a base to the reinforced concrete slabs, which formed the railbed to the major railway line passing through this tunnel. An experimental field test was carried out using this specific mixture to confirm the suitability in relation to the construction method proposed and the properties measured at full scale.
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| 7. |
- Orth-Gomér, K., et al.
(author)
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Marital stress worsens prognosis in women with coronary heart disease : The Stockholm female coronary risk study
- 2000
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In: Journal of the American Medical Association (JAMA). - : American Medical Association. - 0098-7484 .- 1538-3598. ; 284:23, s. 3008-3014
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Journal article (peer-reviewed)abstract
- Context: Psychosocial stress has been associated with incidence of coronary heart disease (CHD) in men, but the prognostic impact of such stress rarely has been studied in women. Objective: To investigate the prognostic impact of psychosocial work stress and marital stress among women with CHD. Design and Setting: Population-based, prospective follow-up study conducted in the city of Stockholm, Sweden. Participants: A total of 292 consecutive female patients aged 30 to 65 years (n = 279 working or cohabiting with a male partner) who were hospitalized for acute myocardial infarction or unstable angina pectoris between February 1991 and February 1994. Patients were followed up from the date of clinical examination until August 1997 (median, 4.8 years). Main Outcome Measures: Recurrent coronary events, including cardiac death, acute myocardial infarction, and revascularization procedures, by marital stress (assessed using the Stockholm Marital Stress Scale, a structured interview) and by work stress (assessed using the ratio of work demand to work control). Results: Among women who were married or cohabiting with a male partner (n = 187), marital stress was associated with a 2.9-fold (95% confidence interval [CI], 1.3-6.5) increased risk of recurrent events after adjustment for age, estrogen status, education level, smoking, diagnosis at index event, diabetes mellitus, systolic blood pressure, smoking, triglyceride level, high-density lipoprotein cholesterol level, and left ventricular dysfunction. Among working women (n = 200), work stress did not significantly predict recurrent coronary events (hazard ratio, 1.6; 95% CI, 0.8-3.3). Conclusions: Our results indicate that marital stress but not work stress predicts poor prognosis in women aged 30 to 65 years with CHD. These findings differ from previous findings in men and suggest that specific preventive measures be tailored to the needs of women with CHD.
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| 8. |
- Akdis, M, et al.
(author)
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Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells
- 2004
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In: Journal of Experimental Medicine. - : Rockefeller University Press. - 0022-1007 .- 1540-9538. ; 199:11, s. 1567-1575
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Journal article (peer-reviewed)abstract
- The mechanisms by which immune responses to nonpathogenic environmental antigens lead to either allergy or nonharmful immunity are unknown. Single allergen-specific T cells constitute a very small fraction of the whole CD4(+) T cell repertoire and can be isolated from the peripheral blood of humans according to their cytokine profile. Freshly purified interferon-gamma-, interleukin (IL)-4-, and IL-10-producing allergen-specific CD4(+) T cells display characteristics of T helper cell (Th)1-, Th2, and T regulatory (Tr)1-like cells, respectively. Tr1 cells consistently represent the dominant subset specific for common environmental allergens in healthy individuals; in contrast, there is a high frequency of allergen-specific IL-4-secreting T cells in allergic individuals. Tr1 cells use multiple suppressive mechanisms, IL-10 and TGF-beta as secreted cytokines, and cytotoxic T lymphocyte antigen 4 and programmed death 1 as surface molecules. Healthy and allergic individuals exhibit all three allergen-specific subsets in different proportions, indicating that a change in the dominant subset may lead to allergy development or recovery. Accordingly, blocking the suppressor activity of Tr1 cells or increasing Th2 cell frequency enhances allergen-specific Th2 cell activation ex vivo. These results indicate that the balance between allergen-specific Tr1 cells and Th2 cells may be decisive in the development of allergy.
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| 9. |
- Brindle, Joanne T, et al.
(author)
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Rapid and Nonivasive Diagnosis of the Presence and Severity of Coronary Heart Disease Using 1H-NMR-Based Metabonomics
- 2002
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In: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 8, s. 1439-45
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Journal article (peer-reviewed)abstract
- Although a wide range of risk factors for coronary heart disease have been identified from population studies, these measures, singly or in combination, are insufficiently powerful to provide a reliable, noninvasive diagnosis of the presence of coronary heart disease. Here we show that pattern-recognition techniques applied to proton nuclear magnetic resonance (1H-NMR) spectra of human serum can correctly diagnose not only the presence, but also the severity, of coronary heart disease. Application of supervised partial least squares-discriminant analysis to orthogonal signal-corrected data sets allows >90% of subjects with stenosis of all three major coronary vessels to be distinguished from subjects with angiographically normal coronary arteries, with a specificity of >90%. Our studies show for the first time a technique capable of providing an accurate, noninvasive and rapid diagnosis of coronary heart disease that can be used clinically, either in population screening or to allow effective targeting of treatments such as statins.
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| 10. |
- Chikatamarla, R., et al.
(author)
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Rockfall impact on protection galleries
- 2004
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Conference paper (peer-reviewed)abstract
- Rockfalls are one of the most prevailing natural hazards in the mountainous regions in Switzer- land. Concrete protection galleries are used to protect the local infrastructure and lifelines against these poten- tial rock impacts. Cushion materials are laid on these galleries to absorb the rockfall impact energy, which is one of the main input parameters in the design of the protection gallery. An attempt has been made to reduce the impact energies by placing a better damping material on the gallery. The high rock impact energy ranges are difficult to model at the laboratory scale. Field tests are generally avoided due to the high costs involved and also due to the singularity of the potential tests. The prototype energy levels can be achieved at the labo- ratory scale with the help of a geotechnical centrifuge. An instrumented model of the protection gallery is ro- tated under high g levels, thereby increasing the unit weight of the material. With the help of appropriate scal- ing laws, the prototype energy levels can be achieved. This paper focuses on the determination of the impact force of a rockfall of a specific energy and the forces induced in the gallery. The maximum acceleration val- ues of the rock and deflection of the galleries are compared for different energy ranges and cushion materials. The test results are later compared with numerical modelling using the finite element program LS-DYNA. Rockfall impact on protection galleries | Request PDF. Available from: https://www.researchgate.net/publication/242415233_Rockfall_impact_on_protection_galleries [accessed Aug 20 2018].
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