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- Pamilo, P, et al.
(author)
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Deleterious mutations can reduce differentiation in small, subdivided populations
- 1999
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In: HEREDITAS. - : HEREDITAS-DISTRIBUTION. - 0018-0661. ; 130:3, s. 257-264
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Journal article (other academic/artistic)abstract
- We study the effects of multilocus selection on genetic differentiation at linked neutral loci by using computer simulations. Two types of selection are examined, purifying selection against deleterious mutations and stabilizing selection at a quantitativ
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- Sajantila, A, et al.
(author)
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Paternal and maternal DNA lineages reveal a bottleneck in the founding of the Finnish population
- 1996
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In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 93:21, s. 12035-12039
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Journal article (peer-reviewed)abstract
- An analysis of Y-chromosomal haplotypes in several European populations reveals an almost monomorphic pattern in the Finns, whereas Y-chromosomal diversity is significantly higher in other populations. Furthermore, analyses of nucleotide positions in the mitochondrial control region that evolve slowly show a decrease in genetic diversity in Finns. Thus, relatively few men and women have contributed the genetic lineages that today survive in the Finnish population. This is likely to have caused the so-called ''Finnish disease heritage''-i.e., the occurrence of several genetic diseases in the Finnish population that are rare elsewhere. A preliminary analysis of the mitochondrial mutations that have accumulated subsequent to the bottleneck suggests that it occurred about 4000 years ago, presumably when populations using agriculture and animal husbandry arrived in Finland.
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