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- Bernstad Saraiva, Anna, et al.
(author)
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Provision of pulpwood and short rotation eucalyptus in Bahia, Brazil : Environmental impacts based on lifecycle assessment methodology
- 2017
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In: Biomass and Bioenergy. - : Elsevier BV. - 0961-9534 .- 1873-2909. ; 105, s. 41-50
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Journal article (peer-reviewed)abstract
- Environmental impacts from cultivation of eucalyptus pulpwood and short rotation eucalyptus in northeast Brazil were investigated using lifecycle assessment methodology. The assessment considers all relevant inputs and outputs, as well as direct land use changes, assuming conversion of grassland (pasture) to areas for eucalyptus plantation. Results show that production of pulpwood eucalyptus is beneficial compared to short rotation eucalyptus in relation to all assessed impact categories, except for climate change (greenhouse gas emissions = 47 kg CO2-eq. t DM−1 pulpwood eucalyptus and 35 kg CO2-eq. t DM−1 short rotation eucalyptus). Excluding emissions from direct land use changes would increase overall GWP from investigated systems with around 5–6%, and changing the assumed land-use prior to land conversion is of decisive character for overall GWP-results from the assessed eucalyptus production systems. Modeling of nutrient balances in the short rotation production system shows a potential need to increase the input of mineral fertilizer in order to compensate for nutrient losses. This would increase environmental impacts from the short rotation system, making pulpwood eucalyptus preferable in relation to all assessed impact categories.
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- Berglund, A., et al.
(author)
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Sex differences in the presentation of stroke
- 2017
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In: Maturitas. - Amsterdam, Netherlands : Elsevier. - 0378-5122 .- 1873-4111. ; 99, s. 47-50
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Research review (peer-reviewed)abstract
- Stroke affects both men and women of all ages, although the condition is more common among the elderly. Stroke occurs at an older age among women than among men; although the incidence is lower among women than among men, as women have a longer life expectancy their lifetime risk is slightly higher. Ischemic stroke is the most common type of stroke; and reperfusion treatment is possible if the patient reaches hospital early enough. Thrombolysis and thrombectomy are time-sensitive treatments - the earlier they are initiated the better is the chance of a positive outcome. It is therefore important to identify a stroke as soon as possible. Medical personnel can readily identify typical stroke symptoms but the presentation of non-traditional stroke symptoms, such as impaired consciousness and altered mental status, is often associated with a significant delay in the identification of stroke and thus delay in or inability to provide treatment. Non-traditional stroke symptoms are reported to be more common in women, who are thereby at risk of delayed recognition of stroke and treatment delay.
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- Castells-Nobau, Anna, et al.
(author)
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Two Algorithms for High-throughput and Multi-parametric Quantification of Drosophila Neuromuscular Junction Morphology
- 2017
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In: Journal of Visualized Experiments. - : JOURNAL OF VISUALIZED EXPERIMENTS. - 1940-087X. ; :123
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Journal article (peer-reviewed)abstract
- Synaptic morphology is tightly related to synaptic efficacy, and in many cases morphological synapse defects ultimately lead to synaptic malfunction. The Drosophila larval neuromuscular junction (NMJ), a well-established model for glutamatergic synapses, has been extensively studied for decades. Identification of mutations causing NMJ morphological defects revealed a repertoire of genes that regulate synapse development and function. Many of these were identified in large-scale studies that focused on qualitative approaches to detect morphological abnormalities of the Drosophila NMJ. A drawback of qualitative analyses is that many subtle players contributing to NMJ morphology likely remain unnoticed. Whereas quantitative analyses are required to detect the subtler morphological differences, such analyses are not yet commonly performed because they are laborious. This protocol describes in detail two image analysis algorithms Drosophila NMJ Morphometrics and Drosophila NMJ Bouton Morphometrics, available as Fiji-compatible macros, for quantitative, accurate and objective morphometric analysis of the Drosophila NMJ. This methodology is developed to analyze NMJ terminals immunolabeled with the commonly used markers Dlg-1 and Brp. Additionally, its wider application to other markers such as Hrp, Csp and Syt is presented in this protocol. The macros are able to assess nine morphological NMJ features: NMJ area, NMJ perimeter, number of boutons, NMJ length, NMJ longest branch length, number of islands, number of branches, number of branching points and number of active zones in the NMJ terminal.
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- Maas, Angela H. E. M., et al.
(author)
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Practice points in gynecardiology : Abnormal uterine bleeding in premenopausal women taking oral anticoagulant or antiplatelet therapy
- 2015
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In: Maturitas. - Amsterdam, Netherlands : Elsevier. - 0378-5122 .- 1873-4111. ; 82:4, s. 355-359
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Journal article (peer-reviewed)abstract
- A growing number of premenopausal women are currently using antithrombotic and/or (dual) antiplatelet therapy for various cardiovascular indications. These may induce or exacerbate abnormal uterine bleeding and more awareness and knowledge among prescribers is required. Heavy and irregular menstrual bleeding is common in women in their forties and may have a variety of underlying causes that require different treatment options. Thus using anticoagulants in premenopausal women demands specific expertise and close collaboration between cardiovascular physicians and gynecologists. In this article we summarize the scope of the problem and provide practical recommendations for the care for young women taking anticoagulants and/or (dual) antiplatelet therapy. We also recommend that more safety data on uterine bleeding with novel anticoagulants in premenopausal women should be obtained.
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- Nijhof, Bonnie, et al.
(author)
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A New Fiji-Based Algorithm That Systematically Quantifies Nine Synaptic Parameters Provides Insights into Drosophila NMJ Morphometry
- 2016
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In: PloS Computational Biology. - : Public Library Science. - 1553-734X .- 1553-7358. ; 11:3
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Journal article (peer-reviewed)abstract
- The morphology of synapses is of central interest in neuroscience because of the intimate relation with synaptic efficacy. Two decades of gene manipulation studies in different animal models have revealed a repertoire of molecules that contribute to synapse development. However, since such studies often assessed only one, or at best a few, morphological features at a given synapse, it remained unaddressed how different structural aspects relate to one another. Furthermore, such focused and sometimes only qualitative approaches likely left many of the more subtle players unnoticed. Here, we present the image analysis algorithm Drosophila_NMJ_Morphometrics, available as a Fiji-compatible macro, for quantitative, accurate and objective synapse morphometry of the Drosophila larval neuromuscular junction (NMJ), a well-established glutamatergic model synapse. We developed this methodology for semi-automated multiparametric analyses of NMJ terminals immunolabeled for the commonly used markers Dlg1 and Brp and showed that it also works for Hrp, Csp and Syt. We demonstrate that gender, genetic background and identity of abdominal body segment consistently and significantly contribute to variability in our data, suggesting that controlling for these parameters is important to minimize variability in quantitative analyses. Correlation and principal component analyses (PCA) were performed to investigate which morphometric parameters are inter-dependent and which ones are regulated rather independently. Based on nine acquired parameters, we identified five morphometric groups: NMJ size, geometry, muscle size, number of NMJ islands and number of active zones. Based on our finding that the parameters of the first two principal components hardly correlated with each other, we suggest that different molecular processes underlie these two morphometric groups. Our study sets the stage for systems morphometry approaches at the well-studied Drosophila NMJ.
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