| 1. |
- Barucca, G., et al.
(author)
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The potential of Λ and Ξ- studies with PANDA at FAIR
- 2021
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In: European Physical Journal A. - : Springer Nature. - 1434-6001 .- 1434-601X. ; 57:4
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Journal article (peer-reviewed)abstract
- The antiproton experiment PANDA at FAIR is designed to bring hadron physics to a new level in terms of scope, precision and accuracy. In this work, its unique capability for studies of hyperons is outlined. We discuss ground-state hyperons as diagnostic tools to study non-perturbative aspects of the strong interaction, and fundamental symmetries. New simulation studies have been carried out for two benchmark hyperon-antihyperon production channels: p¯ p→ Λ¯ Λ and p¯ p→ Ξ¯ +Ξ-. The results, presented in detail in this paper, show that hyperon-antihyperon pairs from these reactions can be exclusively reconstructed with high efficiency and very low background contamination. In addition, the polarisation and spin correlations have been studied, exploiting the weak, self-analysing decay of hyperons and antihyperons. Two independent approaches to the finite efficiency have been applied and evaluated: one standard multidimensional efficiency correction approach, and one efficiency independent approach. The applicability of the latter was thoroughly evaluated for all channels, beam momenta and observables. The standard method yields good results in all cases, and shows that spin observables can be studied with high precision and accuracy already in the first phase of data taking with PANDA.
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| 2. |
- Barucca, G., et al.
(author)
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Study of excited Ξ baryons with the P¯ ANDA detector
- 2021
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In: European Physical Journal A. - : Springer Nature. - 1434-6001 .- 1434-601X. ; 57:4
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Journal article (peer-reviewed)abstract
- The study of baryon excitation spectra provides insight into the inner structure of baryons. So far, most of the world-wide efforts have been directed towards N∗ and Δ spectroscopy. Nevertheless, the study of the double and triple strange baryon spectrum provides independent information to the N∗ and Δ spectra. The future antiproton experiment P¯ANDA will provide direct access to final states containing a Ξ¯ Ξ pair, for which production cross sections up to μb are expected in p¯p reactions. With a luminosity of L= 10 31 cm- 2 s- 1 in the first phase of the experiment, the expected cross sections correspond to a production rate of ∼106events/day. With a nearly 4 π detector acceptance, P¯ANDA will thus be a hyperon factory. In this study, reactions of the type p¯p → Ξ¯ +Ξ∗ - as well as p¯p → Ξ¯ ∗ +Ξ- with various decay modes are investigated. For the exclusive reconstruction of the signal events a full decay tree fit is used, resulting in reconstruction efficiencies between 3 and 5%. This allows high statistics data to be collected within a few weeks of data taking.
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| 3. |
- Kirsanova, M. S., et al.
(author)
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The shocked molecular layer in RCW 120
- 2023
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In: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 520:1, s. 751-760
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Journal article (peer-reviewed)abstract
- Expansion of wind-blown bubbles or H ii regions lead to formation of shocks in the interstellar medium, which compress surrounding gas into dense layers. We made spatially and velocity-resolved observations of the RCW 120 photo-dissociation region (PDR) and nearby molecular gas with CO(6-5) and (CO)-C-13(6-5) lines and distinguished a bright CO-emitting layer, which we related with the dense shocked molecular gas moving away from the ionizing star due to expansion of H ii region. Simulating gas density and temperature, as well as brightness of several CO and C+ emission lines from the PDR, we found reasonable agreement with the observed values. Analysing gas kinematics, we revealed the large-scale shocked PDR and also several dense environments of embedded protostars and outflows. We observe the shocked layer as the most regular structure in the CO(6-5) map and in the velocity space, when the gas around Young stellar objects (YSOs) is dispersed by the outflows.
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| 4. |
- Riabova, K, et al.
(author)
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Molecular Allergen-Specific IgE Recognition Profiles and Cumulative Specific IgE Levels Associated with Phenotypes of Cat Allergy
- 2022
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In: International journal of molecular sciences. - : MDPI AG. - 1422-0067. ; 23:13
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Journal article (peer-reviewed)abstract
- Cat allergy is a major trigger factor for respiratory reactions (asthma and rhinitis) in patients with immunoglobulin E (IgE) sensitization. In this study, we used a comprehensive panel of purified cat allergen molecules (rFel d 1, nFel d 2, rFel d 3, rFel d 4, rFel d 7, and rFel d 8) that were obtained by recombinant expression in Escherichia coli or by purification as natural proteins to study possible associations with different phenotypes of cat allergy (i.e., rhinitis, conjunctivitis, asthma, and dermatitis) by analyzing molecular IgE recognition profiles in a representative cohort of clinically well-characterized adult cat allergic subjects (n = 84). IgE levels specific to each of the allergen molecules and to natural cat allergen extract were quantified by ImmunoCAP measurements. Cumulative IgE levels specific to the cat allergen molecules correlated significantly with IgE levels specific to the cat allergen extract, indicating that the panel of allergen molecules resembled IgE epitopes of the natural allergen source. rFel d 1 represented the major cat allergen, which was recognized by 97.2% of cat allergic patients; however, rFel d 3, rFel d 4, and rFel d 7 each showed IgE reactivity in more than 50% of cat allergic patients, indicating the importance of additional allergens in cat allergy. Patients with cat-related skin symptoms showed a trend toward higher IgE levels and/or frequencies of sensitization to each of the tested allergen molecules compared with patients suffering only from rhinitis or asthma, while there were no such differences between patients with rhinitis and asthma. The IgE levels specific to allergen molecules, the IgE levels specific to cat allergen extract, and the IgE levels specific to rFel d 1 were significantly higher in patients with four different symptoms compared with patients with 1–2 symptoms. This difference was more pronounced for the sum of IgE levels specific to the allergen molecules and to cat extract than for IgE levels specific for rFel d 1 alone. Our study indicates that, in addition to rFel d 1, rFel d 3, rFel d 4, and rFel d 7 must be considered as important cat allergens. Furthermore, the cumulative sum of IgE levels specific to cat allergen molecules seems to be a biomarker for identifying patients with complex phenotypes of cat allergy. These findings are important for the diagnosis of IgE sensitization to cats and for the design of allergen-specific immunotherapies for the treatment and prevention of cat allergy.
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| 5. |
- Semenov, E., et al.
(author)
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INVARIANT BANACH LIMITS AND APPLICATIONS TO NONCOMMUTATIVE GEOMETRY
- 2020
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In: Pacific Journal of Mathematics. - : Mathematical Sciences Publishers. - 0030-8730 .- 1945-5844. ; 306:1, s. 357-373
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Journal article (peer-reviewed)abstract
- A linear functional B on the space of bounded sequences l(infinity) is called a Banach limit if it is positive, normalised and invariant under the shift operator. There are Banach limits which possess additional invariance properties. We prove that every Banach limit invariant under the Cesaro operator is also invariant under all dilation operators. We also prove the "continuous version" of this result and apply it to the theory of singular traces.
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| 6. |
- Semenov, Georgy A., et al.
(author)
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Asymmetric introgression reveals the genetic architecture of a plumage trait
- 2021
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In: Nature Communications. - : Springer Nature. - 2041-1723. ; 12:1
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Journal article (peer-reviewed)abstract
- Genome-wide variation in introgression rates across hybrid zones offers a powerful opportunity for studying population differentiation. One poorly understood pattern of introgression is the geographic displacement of a trait implicated in lineage divergence from genome-wide population boundaries. While difficult to interpret, this pattern can facilitate the dissection of trait genetic architecture because traits become uncoupled from their ancestral genomic background. We studied an example of trait displacement generated by the introgression of head plumage coloration from personata to alba subspecies of the white wagtail. A previous study of their hybrid zone in Siberia revealed that the geographic transition in this sexual signal that mediates assortative mating was offset from other traits and genetic markers. Here we show that head plumage is associated with two small genetic regions. Despite having a simple genetic architecture, head plumage inheritance is consistent with partial dominance and epistasis, which could contribute to its asymmetric introgression. Hybrid zones are windows into the evolutionary process. Semenov et al. find that the head plumage differences between white wagtail subspecies have a simple genetic basis involving two small genetic regions, in which partially dominant and epistatic interactions help to explain how this sexual signal has become decoupled from other plumage traits.
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| 7. |
- Sidorova, M., et al.
(author)
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Magnetoconductance and photoresponse properties of disordered NbTiN films
- 2021
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In: Physical Review B. - : American Physical Society (APS). - 2469-9950 .- 2469-9969. ; 104:18
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Journal article (peer-reviewed)abstract
- We report on the experimental study of phonon properties and electron-phonon scattering in thin superconducting NbTiN films, which are intensively exploited in various applications. Studied NbTiN films with sub-10-nm thicknesses are disordered with respect to electron transport, the Ioffe-Regel parameter of kFle = 2.5-3.0 (kF is the Fermi wave vector, and le is the electron mean free path), the inelastic electron-phonon interaction, and the product qTle << 1 (qT is the wave vector of a thermal phonon). By means of magnetoconductance and photoresponse techniques, we derive the inelastic electron-phonon scattering rate 1/tau e-ph and determine sound velocities and phonon heat capacities. In the temperature range from 12 to 20 K, the scattering rate varies with temperature as 1/tau e-ph proportional to T 3.45 +/- 0.05; its value extrapolated to 10 K amounts to approximately 1/16 ps. Making a comparative analysis of our films and other films used in superconducting devices, such as polycrystalline granular NbN and amorphous WSi, we find a systematic reduction of the sound velocity in all these films by about 50% compared to the corresponding bulk crystalline materials. A corresponding increase in the phonon heat capacities in all these films is, however, less than the Debye model predicts. We attribute these findings to reduced film dimensionality and film morphology.
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| 8. |
- Sidorova, M., et al.
(author)
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Phonon heat capacity and self-heating normal domains in NbTiN nanostrips
- 2022
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In: Superconductors Science and Technology. - : IOP Publishing. - 0953-2048 .- 1361-6668. ; 35:10
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Journal article (peer-reviewed)abstract
- Self-heating normal domains in thin superconducting NbTiN nanostrips with the granular structure were characterized via steady-state hysteretic current-voltage characteristics measured at different substrate temperatures. The temperature dependence and the magnitude of the current, which sustains a domain in equilibrium at different voltages, can only be explained with a phonon heat capacity noticeably less than expected for 3D Debye phonons. This reduced heat capacity coincides with the value obtained earlier from magnetoconductance and photoresponse studies of the same films. The rate of heat flow from electrons at a temperature T-e to phonons in the substrate at a temperature T-B is proportional to (T (p) (e) - T (p)(B)) with the exponent p approximate to 3, which differs from the exponents for heat flows mediated by the electron-phonon interaction or by escaping of 3D Debye phonons via the film/substrate interface. We attribute both findings to the effect of grains on the phonon spectrum of thin NbTiN films. Our findings are significant for understanding the thermal transport in superconducting devices exploiting thin granular films.
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| 9. |
- Turbek, Sheela P., et al.
(author)
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Variable Signatures of Selection Despite Conserved Recombination Landscapes Early in Speciation
- 2021
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In: Journal of Heredity. - : Oxford University Press. - 0022-1503 .- 1465-7333. ; 112:6, s. 485-496
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Journal article (peer-reviewed)abstract
- Recently diverged taxa often exhibit heterogeneous landscapes of genomic differentiation, characterized by regions of elevated differentiation on an otherwise homogeneous background. While divergence peaks are generally interpreted as regions responsible for reproductive isolation, they can also arise due to background selection, selective sweeps unrelated to speciation, and variation in recombination and mutation rates. To investigate the association between patterns of recombination and landscapes of genomic differentiation during the early stages of speciation, we generated fine-scale recombination maps for six southern capuchino seedeaters (Sporophila) and two subspecies of White Wagtail (Motacilla alba), two recent avian radiations in which divergent selection on pigmentation genes has likely generated peaks of differentiation. We compared these recombination maps to those of Collared (Ficedula albicollis) and Pied Flycatchers (Ficedula hypoleuca), non-sister taxa characterized by moderate genomic divergence and a heterogenous landscape of genomic differentiation shaped in part by background selection. Although recombination landscapes were conserved within all three systems, we documented a weaker negative correlation between recombination rate and genomic differentiation in the recent radiations. All divergence peaks between capuchinos, wagtails, and flycatchers were located in regions with lower-than-average recombination rates, and most divergence peaks in capuchinos and flycatchers fell in regions of exceptionally reduced recombination. Thus, co-adapted allelic combinations in these regions may have been protected early in divergence, facilitating rapid diversification. Despite largely conserved recombination landscapes, divergence peaks are specific to each focal comparison in capuchinos, suggesting that regions of elevated differentiation have not been generated by variation in recombination rate alone.
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| 10. |
- Vakhrushev, Y, et al.
(author)
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RBM20-Associated Ventricular Arrhythmias in a Patient with Structurally Normal Heart
- 2021
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In: Genes. - : MDPI AG. - 2073-4425. ; 12:1
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Journal article (other academic/artistic)abstract
- RBM20 (RNA-binding motif protein 20) is a splicing factor targeting multiple cardiac genes, and its mutations cause cardiomyopathies. Originally, RBM20 mutations were discovered to cause the development of dilated cardiomyopathy by erroneous splicing of the gene TTN (titin). Titin is a giant protein found in a structure of the sarcomere that functions as a molecular spring and provides a passive stiffness to the cardiomyocyte. Later, RBM20 mutations were also described in association with arrhythmogenic right ventricular cardiomyopathy and left ventricular noncompaction cardiomyopathy. Here, we present a clinical case of a rare arrhythmogenic phenotype and no structural cardiac abnormalities associated with a RBM20 genetic variant of uncertain significance.
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