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Träfflista för sökning "WFRF:(Sherina N) srt2:(2020-2024)"

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1.	Marcotte, H, et al. (author) Conversion of monoclonal IgG to dimeric and secretory IgA restores neutralizing ability and prevents infection of Omicron lineages 2024 In: Proceedings of the National Academy of Sciences of the United States of America. - 1091-6490. ; 121:3, s. e2315354120- Journal article (peer-reviewed)
2.	Malkani, Sherina, et al. (author) Circulating miRNA Spaceflight Signature Reveals Targets for Countermeasure Development 2020 In: Cell Reports. - : Elsevier BV. - 2211-1247. ; 33:10 Journal article (peer-reviewed)abstract We have identified and validated a spaceflight-associated microRNA (miRNA) signature that is shared by rodents and humans in response to simulated, short-duration and long-duration spaceflight. Previous studies have identified miRNAs that regulate rodent responses to spaceflight in low-Earth orbit, and we have confirmed the expression of these proposed spaceflight-associated miRNAs in rodents reacting to simulated spaceflight conditions. Moreover, astronaut samples from the NASA Twins Study confirmed these expression signatures in miRNA sequencing, single-cell RNA sequencing (scRNA-seq), and single-cell assay for transposase accessible chromatin (scATAC-seq) data. Additionally, a subset of these miRNAs (miR-125, miR-16, and let-7a) was found to regulate vascular damage caused by simulated deep space radiation. To demonstrate the physiological relevance of key spaceflight-associated miRNAs, we utilized antagomirs to inhibit their expression and successfully rescue simulated deep-space-radiation-mediated damage in human 3D vascular constructs.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Chen, L (1); Feng, L. (1); Guerra, C. (1); KLARESKOG, L (1); Svensson, L (1); Rezaei, N (1); show more...; Cao, Y (1); Abolhassani, H (1); Yang, X. (1); Yang, J. (1); Wang, Q. (1); Marcotte, H (1); Borte, S (1); Du, L (1); Zuo, F (1); Hammarström, L (1); Pan-Hammarström, Q (1); Xue, Y. (1); Afshinnekoo, Ebrahim (1); Mason, Christopher E ... (1); Sun, R (1); Qin, C (1); Grönwall, C (1); Butler, Daniel (1); Fromm, Bastian (1); Shi, Z. (1); Schubert, M. (1); Tarbier, Marcel (1); Friedländer, Marc R. (1); Bao, L (1); Xie, XS (1); Cassaniti, I (1); Kumagai-Braesch, M (1); Baldanti, F (1); Piralla, A (1); Pedotti, M (1); Simonelli, L (1); Calzolai, L (1); Varani, L (1); Cavalli, A (1); Robbiani, DF (1); Xiao, J (1); Bezdan, Daniela (1); Meydan, Cem (1); Percivalle, E (1); Sammartino, JC (1); Su, C. (1); Chin, Christopher R. (1); Melnick, Ari (1); He, P. (1); show less...

University: Stockholm University (1); Karolinska Institutet (1)

Language: English (2)

Research subject (UKÄ/SCB): Natural sciences (1)

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