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Search: WFRF:(Sironen T) > (2005-2009)

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  • Sironen, T, et al. (author)
  • Quasispecies dynamics and fixation of a synonymous mutation in hantavirus transmission
  • 2008
  • In: The Journal of general virology. - : Microbiology Society. - 0022-1317 .- 1465-2099. ; 89:Pt 5, s. 1309-1313
  • Journal article (peer-reviewed)abstract
    • RNA-dependent RNA polymerases, the key enzymes in replication of RNA viruses, have a low fidelity; thus, these viruses replicate as a swarm of mutants termed viral quasispecies. Constant generation of new mutations allows RNA viruses to adapt swiftly to a novel environment through selection of both pre-existing and de novo-generated genetic variants. Here, quasispecies dynamics were studied in vivo in controlled hantavirus transmission from experimentally infected to naïve rodents through infested cage bedding. An elementary step of virus microevolution was apparent, as one synonymous mutation (A759G) repeatedly became fixed in the viral RNA quasispecies populations in the recipient animals.
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  • Result 1-2 of 2
Type of publication
journal article (2)
Type of content
peer-reviewed (2)
Author/Editor
Vaheri, A (2)
Lundkvist, A (2)
Plyusnin, A (2)
Sironen, T (2)
Klingstrom, J (1)
Andersson, LC (1)
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Kallio, ER (1)
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University
Karolinska Institutet (2)
Language
English (2)
Year
2008 (2)

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