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| 2. |
- Almlöf, Erik, 1985-
(author)
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Slutrapport - Självkörande fullängdsbuss på Tvärförbindelse Södertörn
- 2021
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Reports (pop. science, debate, etc.)abstract
- Föreliggande slutrapport är finansierad av Trafikverkets FoI portfölj, strategiska initiativ,för projekt Självkörande eldriven stombuss på Tvärförbindelse Södertörn – En skalbarfallstudie (TRV 2019/118695). Partners i projektet är Trafikverket, Scania, Volvo, Keolis,KTH samt Sweco där även Trafikförvaltningen Region Stockholm, Nobina och projektTvärförbindelse Södertörn har bidragit till arbetet som pågått från maj 2020 till mars 2021.Ansvarig för projektet inom Trafikverket har varit Stora projekt.För att skapa en förståelse för konsekvenser av tekniska utveckling i relation tillnödvändiga fysiska och digitala åtgärder har tre scenarier tagits fram: Bus Driver Plus,Automation with Adaption och Automation Utopia. Dessa scenarier beskriver olika nivåerav automation och behov av kringliggande stödsystem. I det första scenario finns enförare ombord på bussen som tar över körningen vid farliga situationer. Det andrascenariot avser en självkörande buss utan förare där den fysiska infrastrukturen haranpassats genom ett införande av ett eget busskörfält. Det sista scenariot beskriver enframtid där bussen helt förlitar sig på digital teknik och en operatör kontrollerar körningenav flera fordon från ett avsides kontrolltorn.De tre scenarierna utvärderades genom en samlad effektbedömning, Trafikverkets metodför att utvärdera åtgärder. Resultaten visar att den största vinsten av automatisering kanhandla om resenärernas bekvämlighet och inte nödvändigtvis om att minimera kostnaderför förare. Antaganden om att resenärerna kan uppleva resan bekvämare är troligtvisöverskattade, men resultaten visar att även små förbättringar i bekvämlighet kan ge storasamhälleliga vinster.Scenariot där bussen har ett eget körfält innebär mycket stora kostnader och är troligtvisinte ekonomiskt försvarbart. Dessutom kommer enbart en busslinje att trafikeramotorleden som dessutom består av 3 tunnlar. Vidare är det inte säkert att den aktör somgör nödvändiga investeringar är den aktör som får ta del av de samhälleliga vinsterna. Iscenariot skulle Trafikverket stå för stora delar av investeringskostnaden, medan vinsten för personalbesparingar uppstår för Region Stockholm och kollektivtrafikresenärerna somåker längs sträckan.Projektet har även undersökt hur multimodala hubbar (nod som möjliggör smidigt bytemellan olika transportmedel) längs med förbindelsen kan stödja eldrivna och självkörandebussar. Det är viktigt att ny väginfrastruktur bidrar till en attraktiv kollektivtrafik därresenärer i första hand väljer buss istället för bil. För att eldrivna och självkörande bussarska införas behöver Region Stockholm ställa nya krav i upphandlingar för attåstadkomma en förändring i transportsystemet. Nya krav som skapar ekonomiskaincitament för operatörer som utför den operativa verksamheten över lång tid. Det är dockproblematiskt att ställa krav på eldrift eftersom det saknas tillgänglig infrastruktur iStockholm.Avseende självkörande fullängdsbussar är tekniken helt enkelt inte tillräckligt mogen idag.Dock tror många experter att självkörande bussar kommer att införas, både i stadsmiljöoch glesbygd, när tekniken och samhället är redo för det, gissningsvis kring år 2030.
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| 3. |
- Eklund, Linda, et al.
(author)
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An experimental exposure study revealing composite airway effects of physical exercise in a subzero environment
- 2021
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In: International Journal of Circumpolar Health. - : Taylor & Francis. - 1239-9736 .- 2242-3982. ; 80:1
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Journal article (peer-reviewed)abstract
- Exposure to a cold climate is associated with an increased morbidity and mortality, but the specific mechanisms are largely unknown. People with cardiopulmonary disease and winter endurance athletes are particularly vulnerable. This study aimed to map multiple domains of airway responses to exercise in subzero temperature in healthy individuals.Thirty-one healthy subjects underwent whole-body exposures for 50 minutes on two occasions in an environmental chamber with intermittent moderate-intensity exercise in +10 °C and -10 °C. Lung function, plasma/urine CC16 , and symptoms were investigated before and after exposures.Compared to baseline, exercise in -10 °C decreased FEV1 (p=0.002), FEV1/FVC (p<0.001), and increased R20Hz (p=0.016), with no differences between exposures. Reactance increased after +10 °C (p=0.005), which differed (p=0.042) from a blunted response after exercise in -10 °C. Plasma CC16 increased significantly within exposures, without differences between exposures. Exercise in -10 °C elicited more intense symptoms from the upper airways, compared to +10 °C. Symptoms from the lower airways were few and mild. Short-duration moderate-intensity exercise in -10 °C induces mild symptoms from the lower airways, no lung function decrements or enhanced leakage of biomarkers of airway epithelial injury, and no peripheral bronchodilatation, compared to exercise in +10 °C.
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| 4. |
- Eklund, Linda, 1982-
(author)
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Cold air, physical activity, and the airways : epidemiological and experimental studies
- 2023
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Doctoral thesis (other academic/artistic)abstract
- Background: Cold exposure is associated with increased morbidity and mortality. Elite cross-country skiers are regularly exposed to cold, dry air and have a high prevalence of asthma compared to the Swedish population. However, evidence is limited regarding how a combination of sub-zero temperatures and physical activity affects the airways of healthy individuals.Aims: The aims of this thesis were to study the prevalence of self-reported asthma, age at asthma onset, and predictors of asthma in Swedish endurance athletes, with a focus on cross-country skiers. This thesis also aimed to assess the effects of subzero temperature and physical activity on healthy human airways.Methods: Study 1 (papers I-II) consisted of an annual postal questionnaire investigating asthma prevalence and predictors of asthma that was sent to invited athletes in 2011–2015. Invited athletes were Swedish elite cross-country skiers, biathletes, ski orienteers, and orienteers from Swedish National Elite Sport Schools, national teams, and Swedish Ski Universities, or top orienteers according to national ranking. Former Swedish Olympic skiers and an adolescent reference group were invited in 2013. Paper I included cross-sectional data from 2011 for adolescents/adults and from 2013 for former skiers (n=491). Paper II included adolescent elite skiers (n=253) from the Swedish National Elite Sport Schools invited during 2011-2013, as well as a reference group (n=500) aged 16-20 years that was matched for school municipalities and invited in 2013. Study 2 (papers III-IV) comprised whole-body experimental exposure of healthy adults to sub-zero temperatures and exercise in an environmental chamber. Lung function and biochemical markers in plasma and urine were measured before and after exposure. Symptoms were investigated before, during, and after exposure. In both trials, study subjects were exposed for 50 min on two separate occasions in randomized order. Paper III comprised 31 subjects and moderate-intensity exercise (30 min running at 62-78% of VO2max), at 10°C vs. -10°C. Paper IV included 29 subjects and hard-intensity exercise (30 min of running at 85% of VO2max) vs. rest, both at a temperature of -15°C.Results: In paper I, the overall response rate was 82%. Athletes reporting asthma in the different age categories were: 29% of skiers (38% of the female skiers) and 17% of orienteers (p=0.071) among 15 to 19-year-olds; 35% of skiers and 16% of orienteers (p=0.029) among 20 to 34-year-olds; and 22% of the skiers aged 40–94 years. Asthma onset occurred in adolescence among the active athletes. Increasing age, female sex, allergy, family history of allergy/asthma, and being a skier were predictors of self-reported physician-diagnosed asthma. In paper II, the response rate was 96% for skiers and 48% for the reference group. Skiers reported a higher prevalence of self-reported physician-diagnosed asthma than the reference population (27% vs. 19%, p=0.046). Physician-diagnosed asthma was more frequently reported by female skiers than male skiers (34% vs. 20%, p=0.021). Median age at asthma onset was higher among skiers than in the reference population (12.0 vs. 8.0 years; p<0.001). Female sex, family history of asthma, nasal allergy, and being a skier were risk factors associated with self-reported physician-diagnosed asthma. In paper III, exercise at -10°C decreased FEV1 (p=0.002) and FEV1/FVC (p<0.001) and increased resistance at 20 Hz (p=0.016) to similar magnitudes as exercise at 10°C. Exercise at 10°C increased reactance (p=0.005), which differed (p=0.042) from a less pronounced response after exercise at -10°C. Plasma CC16 increased similarly after both exposures, without significant differences. More intense symptoms from the upper airways were reported after exercise at -10°C than at 10°C. Symptoms from the lower airways were few and mild. In paper IV, FEV1 decreased from baseline after both rest (p<0.001) and exercise (p=0.012) at -15°C, with no differences between exposures. Compared to rest, exercise at -15°C induced greater increases in reactance (p=0.023), plasma CC16 (p<0.001), and plasma IL-8 (p<0.001). Exercise gave rise to more intense symptoms from the lower airways, whereas rest induced more general symptoms.Conclusions: In the 1990s, a high prevalence of physician-diagnosed asthma was reported among Swedish elite cross-country skiers, and our studies show that this has not changed. Asthma onset commonly occurs in early adolescence among skiers, in the beginning of their career. Being an elite skier is an independent risk factor associated with asthma. Targeted preventive measures should be introduced at an early age to avoid the development of asthma in endurance athletes. Healthy individuals performing short-duration moderate- and hard-intensity exercise in sub-zero temperatures responded with lung function changes and an increased airway permeability. These findings warrant further research on airway responses to sub-zero temperatures in vulnerable individuals such as elite endurance athletes.
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| 5. |
- Eklund, Linda M., et al.
(author)
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Cold air exposure at -15 °C induces more airway symptoms and epithelial stress during heavy exercise than rest without aggravated airway constriction
- 2022
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In: European Journal of Applied Physiology. - : Springer. - 1439-6319 .- 1439-6327. ; 122:12, s. 2533-2544
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Journal article (peer-reviewed)abstract
- Purpose: Exposure to cold air may harm the airways. It is unclear to what extent heavy exercise adds to the cold-induced effects on peripheral airways, airway epithelium, and systemic immunity among healthy individuals. We investigated acute effects of heavy exercise in sub-zero temperatures on the healthy airways.Methods: Twenty-nine healthy individuals underwent whole body exposures to cold air in an environmental chamber at − 15 °C for 50 min on two occasions; a 35-min exercise protocol consisting of a 5-min warm-up followed by 2 × 15 min of running at 85% of VO2max vs. 50 min at rest. Lung function was measured by impulse oscillometry (IOS) and spirometry before and immediately after exposures. CC16 in plasma and urine, and cytokines in plasma were measured before and 60 min after exposures. Symptoms were surveyed pre-, during and post-trials.Results: FEV1 decreased after rest (− 0.10 ± 0.03 L, p < 0.001) and after exercise (− 0.06 ± 0.02 L, p = 0.012), with no difference between trials. Exercise in − 15 °C induced greater increases in lung reactance (X5; p = 0.023), plasma CC16 (p < 0.001) as well as plasma IL-8 (p < 0.001), compared to rest. Exercise induced more intense symptoms from the lower airways, whereas rest gave rise to more general symptoms.Conclusion: Heavy exercise during cold air exposure at − 15 °C induced signs of an airway constriction to a similar extent as rest in the same environment. However, biochemical signs of airway epithelial stress, cytokine responses, and symptoms from the lower airways were more pronounced after the exercise trial.
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| 6. |
- Hagell, Peter, et al.
(author)
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Apomorphine formulation may influence subcutaneous complications from continuous subcutaneous apomorphine infusion in Parkinson's disease
- 2020
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In: Journal of Neurology. - 0340-5354 .- 1432-1459. ; 267:11, s. 3411-3417
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Journal article (peer-reviewed)abstract
- Continuous subcutaneous (s.c.) apomorphine infusion is an effective therapy for Parkinson's disease (PD), but a limitation is the formation of troublesome s.c. nodules. Various chemically non-identical apomorphine formulations are available. Anecdotal experiences have suggested that shifting from one of these (Apo-Go PumpFill®; apoGPF) to another (Apomorphine PharmSwed®; apoPS) may influence the occurrence and severity of s.c. nodules. We, therefore, followed 15 people with advanced PD (median PD-duration, 15 years; median "off"-phase Hoehn and Yahr, IV) on apoGPF and with troublesome s.c. nodules who were switched to apoPS. Data were collected at baseline, at the time of switching, and at a median of 1, 2.5, and 7.3 months post-switch. Total nodule numbers (P < 0.001), size (P < 0.001), consistency (P < 0.001), skin changes (P = 0.058), and pain (P ≤ 0.032) improved over the observation period. PD severity and dyskinesias tended to improve and increase, respectively. Apomorphine doses were stable, but levodopa doses increased by 100 mg/day. Patient-reported apomorphine efficacy tended to increase and all participants remained on apoPS throughout the observation period; with the main patient-reported reason being improved nodules. These observations suggest that patients with s.c. nodules caused by apoGPF may benefit from switching to apoPS in terms of s.c. nodule occurrence and severity. Alternatively, observed benefits may have been due to the switch itself. As nodule formation is a limiting factor in apomorphine treatment, a controlled prospective study comparing local tolerance with different formulations is warranted.
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| 7. |
- Hagell, Peter, et al.
(author)
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Apomorphine formulation may influence subcutaneous complications from continuous subcutaneous apomorphine infusion in Parkinson's disease
- 2020
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In: Journal of Neurology. - : D. Steinkopff-Verlag. - 0340-5354 .- 1432-1459. ; 267:11, s. 3411-3417
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Journal article (peer-reviewed)abstract
- Continuous subcutaneous (s.c.) apomorphine infusion is an effective therapy for Parkinson's disease (PD), but a limitation is the formation of troublesome s.c. nodules. Various chemically non-identical apomorphine formulations are available. Anecdotal experiences have suggested that shifting from one of these (Apo-Go PumpFill®; apoGPF) to another (Apomorphine PharmSwed®; apoPS) may influence the occurrence and severity of s.c. nodules. We, therefore, followed 15 people with advanced PD (median PD-duration, 15 years; median "off"-phase Hoehn and Yahr, IV) on apoGPF and with troublesome s.c. nodules who were switched to apoPS. Data were collected at baseline, at the time of switching, and at a median of 1, 2.5, and 7.3 months post-switch. Total nodule numbers (P < 0.001), size (P < 0.001), consistency (P < 0.001), skin changes (P = 0.058), and pain (P ≤ 0.032) improved over the observation period. PD severity and dyskinesias tended to improve and increase, respectively. Apomorphine doses were stable, but levodopa doses increased by 100 mg/day. Patient-reported apomorphine efficacy tended to increase and all participants remained on apoPS throughout the observation period; with the main patient-reported reason being improved nodules. These observations suggest that patients with s.c. nodules caused by apoGPF may benefit from switching to apoPS in terms of s.c. nodule occurrence and severity. Alternatively, observed benefits may have been due to the switch itself. As nodule formation is a limiting factor in apomorphine treatment, a controlled prospective study comparing local tolerance with different formulations is warranted.
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| 8. |
- Holmquist, Björn, et al.
(author)
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Approximating Noncentral Chi-Squared to the Moments and Distribution of the Likelihood Ratio Statistic for Multinomial Goodness of Fit
- 2020
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In: Recent Developments in Multivariate and Random Matrix Analysis : Festschrift in Honour of Dietrich von Rosen - Festschrift in Honour of Dietrich von Rosen. - Cham : Springer International Publishing. - 9783030567736 - 9783030567729
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Book chapter (peer-reviewed)abstract
- The chi-square distribution is often assumed to hold for the asymptotic distribution of two times the log likelihood ratio statistic under the null hypothesis. Approximations are derived for the mean and variance of G2, the likelihood ratio statistic for testing goodness of fit in a s category multinomial distribution. The first two moments of G2 are used to fit the distribution of G2 to a noncentral chi-square distribution. The fit is generally better than earlier attempts to fit to scaled versions of asymptotic central chi-square distributions. The results enlighten the complex role of the dimension of the multivariate variable in relation to the sample size, for asymptotic likelihood ratio distribution results to hold.
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| 9. |
- Jensen, Theis Zetner Trolle, et al.
(author)
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An integrated analysis of Maglemose bone points reframes the Early Mesolithic of Southern Scandinavia
- 2020
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 10:1
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Journal article (peer-reviewed)abstract
- The extensive peat bogs of Southern Scandinavia have yielded rich Mesolithic archaeological assemblages, with one of the most iconic artefacts being the bone point. Although great in number they remain understudied. Here we present a combined investigation of the typology, protein-based species composition, and absolute chronology of Maglemosian bone points. The majority of the bone points are made from cervids and bovines. However, changes both in species composition and barb morphology can be directly linked to a paucity of finds lasting nearly 600 years in Southern Scandinavia around 10,300 cal BP. We hypothesize that this hiatus was climate-driven and forced hunter-gatherers to abandon the lakes. Furthermore, the marked change in bone points coincides with a change in lithic technology. We, therefore, propose that the Maglemose culture in Southern Scandinavia is fundamentally divided into an Early Complex and a Late Complex.
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| 10. |
- Li, Yi -Hsin, et al.
(author)
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Segmentation-based Initialization for Steered Mixture of Experts
- 2023
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In: 2023 IEEE International Conference on Visual Communications and Image Processing (VCIP). - : IEEE conference proceedings. - 9798350359855
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Conference paper (peer-reviewed)abstract
- The Steered-Mixture-of-Experts (SMoE) model is an edge-Aware kernel representation that has successfully been explored for the compression of images, video, and higher-dimensional data such as light fields. The present work aims to leverage the potential for enhanced compression gains through efficient kernel reduction. We propose a fast segmentation-based strategy to identify a sufficient number of kernels for representing an image and giving initial kernel parametrization. The strategy implies both reduced memory footprint and reduced computational complexity for the subsequent parameter optimization, resulting in an overall faster processing time. Fewer kernels, when combined with the inherent sparsity of the SMoEs, further enhance the overall compression performance. Empirical evaluations demonstrate a gain of 0.3-1.0 dB in PSNR for a constant number of kernels, and the use of 23 % less kernels and 25 % less time for constant PSNR. The results highlight the feasibility and practicality of the approach, positioning it as a valuable solution for various image-related applications, including image compression.
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