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Träfflista för sökning "WFRF:(Sjaastad I.) srt2:(2020-2023)"

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1.	Andreassen, K, et al. (author) Beneficial effects of exercise initiated before development of hypertrophic cardiomyopathy in genotype-positive mice 2023 In: American journal of physiology. Heart and circulatory physiology. - 1522-1539. ; 324:6, s. H881-H892 Journal article (peer-reviewed)
2.	Andreassen, K, et al. (author) Beneficial effects of exercise initiated before development of hypertrophic cardiomyopathy in genotype-positive mice 2023 In: American journal of physiology. Heart and circulatory physiology. - 1522-1539. ; 324:6, s. H881-H892 Journal article (peer-reviewed)
3.	Andreassen, K, et al. (author) Effects of exercise training in humans and mice with hypertrophic cardiomyopathy-associated genetic variants 2022 In: EUROPEAN JOURNAL OF HEART FAILURE. - 1388-9842. ; 24, s. 6-6 Conference paper (other academic/artistic)
4.	Robinson, EL, et al. (author) MSK-Mediated Phosphorylation of Histone H3 Ser28 Couples MAPK Signalling with Early Gene Induction and Cardiac Hypertrophy 2022 In: Cells. - : MDPI AG. - 2073-4409. ; 11:4 Journal article (peer-reviewed)abstract Heart failure is a leading cause of death that develops subsequent to deleterious hypertrophic cardiac remodelling. MAPK pathways play a key role in coordinating the induction of gene expression during hypertrophy. Induction of the immediate early gene (IEG) response including activator protein 1 (AP-1) complex factors is a necessary and early event in this process. How MAPK and IEG expression are coupled during cardiac hypertrophy is not resolved. Here, in vitro, in rodent models and in human samples, we demonstrate that MAPK-stimulated IEG induction depends on the mitogen and stress-activated protein kinase (MSK) and its phosphorylation of histone H3 at serine 28 (pH3S28). pH3S28 in IEG promoters in turn recruits Brg1, a BAF60 ATP-dependent chromatin remodelling complex component, initiating gene expression. Without MSK activity and IEG induction, the hypertrophic response is suppressed. These studies provide new mechanistic insights into the role of MAPK pathways in signalling to the epigenome and regulation of gene expression during cardiac hypertrophy.

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Type of publication: journal article (3); conference paper (1)

Type of content: peer-reviewed (3); other academic/artistic (1)

Author/Editor: Sjaastad, I (4); Edvardsen, T (3); Andreassen, K (3); Rixon, C (3); Hauge-Iversen, IM (3); Christensen, G (3); show more...; Lunde, IG (3); Stokke, MK (3); Haugaa, KH (2); Hansen, MH (2); Sadredini, M (2); Erusappan, PM (2); Wang, X. (1); Zhang, L. (1); Liu, W. (1); Alkass, K (1); Bergmann, O (1); Zhang, LL (1); Dejgaard, L (1); Lie, O (1); Fink, T (1); Haugaa, K (1); Drawnel, FM (1); Okkenhaug, H (1); Robinson, EL (1); Roderick, HL (1); Mehdi, S (1); Archer, CR (1); Aronsen, JM (1); Nagaraju, CK (1); Sipido, KR (1); Arthur, JSC (1); show less...

University: Karolinska Institutet (4)

Language: English (4)

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