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- Agardh, Carl-David, et al.
(author)
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The Aldose Reductase Inhibitor Fidarestat Suppresses Ischemia-Reperfusion-Induced Inflammatory Response in Rat Retina.
- 2009
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In: Pharmacology. - : S. Karger AG. - 1423-0313 .- 0031-7012. ; 84:5, s. 257-263
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Journal article (peer-reviewed)abstract
- Recent studies suggest that increased aldose reductase (AR) activity plays an important role in ischemia-reperfusion injury in the retina. The mechanisms are not completely understood, but may be linked to inflammation. In the present study, we investigated whether the AR inhibitor fidarestat suppressed the retinal inflammatory response induced by ischemia-reperfusion in a rat model. The inflammatory response was manifested by increased gene expression of tumor necrosis factor-alpha and intercellular adhesion molecule-1 (ICAM-1) as well as elevated protein levels of soluble ICAM-1. This response was partially suppressed by the AR inhibitor fidarestat. The findings may reveal beneficial effects of AR inhibition on retinal inflammation associated with ischemia-reperfusion and are in agreement with recent developments in pharmacological research suggesting that pathological conditions other than diabetes may benefit from AR inhibitors.
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| 2. |
- Chapin, III F.S., et al.
(author)
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Resilience-based stewardship : Strategies for navigating sustainable pathways in a changing world.
- 2009
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In: Principles of ecosystem stewardship. - New York : Springer Verlag. - 9780387730332 ; , s. 319-337
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Book chapter (pop. science, debate, etc.)abstract
- Accelerated global changes in climate, environment, and social–ecological systems demand a transformation in human perceptions of our place in nature and patterns of resource use. The biology and culture of Homo sapiens evolved for about 95% of our species’ history in hunting-and-gathering societies before the emergence of settled agriculture. We have lived in complex societies for about 3%, and in industrial societies using fossil fuels for about 0.1% of our history. The pace of cultural evolution, including governance arrangements and resource-use patterns, appears insufficient to adjust to the rate and magnitude of technological innovations, human population increases, and environmental impacts that have occurred. Many of these changes are accelerating, causing unsustainable exploitation of ecosystems, including many boreal and tropical forests, drylands, and marine fisheries. The net effect has been serious degradation of the planet’s life-support system on which societal development ultimately depends (see Chapters 2 and 14.
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| 3. |
- Elsik, Christine G., et al.
(author)
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The Genome Sequence of Taurine Cattle : A Window to Ruminant Biology and Evolution
- 2009
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In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 324:5926, s. 522-528
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Journal article (peer-reviewed)abstract
- To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.
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| 5. |
- Li, Wei, 1979-
(author)
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Towards a Person-Centric Context Aware System
- 2006
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Licentiate thesis (other academic/artistic)abstract
- A recent trend is to integrate sensing, communication, and computation into every aspect of our daily life, ranging from various user devices to physical environment. The goal is to give computer systems an awareness of the users and their situations, so that they can support their diverse interaction needs at anytime, any place. A major problem hindering achieving this promising goal is that the users usually play a passive role in these systems with little possibility to interfere with the processing. Additionally, there is no option for the user to prevent being monitored by the system. This drawback stems from the lack of an independent and consistent user oriented viewpoint in current ubiquitous computing systems, which can easily result in the occurrence of user privacy invasion and misinterpretation of the user. To overcome this problem, this thesis proposes a Person-Centric Context Aware System architecture, helping to preserve an independent representation for each individual user to different computer systems. The main idea embraced in this system architecture is that the users are the owners of their personal information, thus they should have the control of how their information will be used by others. In the design of this system architecture, a number of important issues have been addressed with their corresponding solutions in terms of different system components. Among these issues, three are identified as the most crucial ones, and hence these issues have received most of our efforts to provide better solutions: Context Data Communication, Location Detection, and Communication Anonymity support. A prototype system constructed during the process of developing each specific solution is also presented. Together these comprise the main contributions of this thesis work. Finally, our concluding remarks are presented together with our planned future work, based on the current implementation of a Person-Centric Context Aware System.
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| 8. |
- Öhman, Jenny, et al.
(author)
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Tumor necrosis factor-alpha does not mediate diabetes-induced vascular inflammation in mice.
- 2009
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In: Arteriosclerosis, Thrombosis and Vascular Biology. - 1524-4636 .- 1079-5642. ; 29:10, s. 1465-1470
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Journal article (peer-reviewed)abstract
- OBJECTIVE: Vascular inflammation is a key feature of both micro- and macrovascular complications in diabetes. Several lines of evidence have implicated the cytokine tumor necrosis factor (TNF) alpha as an important mediator of inflammation in diabetes. In the present study we evaluated the role of TNF alpha in streptozotocin (STZ)-induced diabetes on vascular inflammation in C57BL/6 wild-type and apoE-/- mice. METHODS AND RESULTS: Diabetes increased the expression of vascular cell adhesion molecule (VCAM)-1 in cerebral arteries 150 m in diameter as well as the macrophage accumulation in aortic root atherosclerotic plaques in apoE-/- mice. A more pronounced vascular inflammatory response was observed in diabetic TNF alpha-deficient apoE-/- mice. These mice were also characterized by increased accumulation of IgG and IgM autoantibodies in atherosclerotic lesions. Diabetes also increased VCAM-1 expression and plaque formation in apoE-competent TNF alpha -/- mice, whereas no such effects were observed in C57BL/6 wild-type mice. CONCLUSIONS: The present findings suggest that TNF alpha does not mediate diabetic-induced vascular inflammation in mice and reveal an unexpected protective role for TNF alpha. These effects are partly attributable to a direct antiinflammatory role of TNF alpha, but may also reflect a defective development of the immune system in these mice.
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