| 1. |
|
|
| 2. |
- Rozengurt, E., et al.
(author)
-
Signal transduction in mitogenesis : further evidence for multiple pathways
- 1988
-
In: Cold Spring Harbor Symposia on Quantitative Biology. - : Cold Spring Harbor Laboratory Press (CSHL). - 0091-7451 .- 1943-4456. ; 53, s. 945-954
-
Journal article (peer-reviewed)abstract
- This extract was created in the absence of an abstract.ExcerptGrowth factors are implicated in a wide variety of physiological and pathological processes, including embryogenesis, hematopoiesis, wound healing, immune responses, atherosclerosis, and neoplasis (Evered et al. 1985; Sporn and Roberts 1986). An important link between growth factors and their receptors and oncogene products has also been established (Heldin and Westermark 1984; Weinstein 1987). Thus, the elucidation of the mechanism of action of growth factors has emerged as one of the fundamental problems in biology and may prove crucial for understanding the unrestrained proliferation of cancer cells.Many studis of growth factors have used cultured fibroblasts, such as 3T3 cells, as a model system. These cells cease to proliferate when they deplete the medium of its growth-promoting activity. Such quiescent cells can be stimulated to reinitiate DNA synthesis and cell division either by replenishing the medium with fresh serum or by the addition of growth factors or pharmacological agents in serum-free...
|
|
| 3. |
|
|
| 4. |
- Li, C-H., et al.
(author)
-
A lattice resolution study of the martensitic transformation of small iron particles in a copper matrix
- 1985
-
In: Acta Metallurgica. - : Elsevier BV. - 0001-6160. ; 33:2, s. 317-328
-
Journal article (peer-reviewed)abstract
- The martensitic transformation of small, fully coherent, gamma iron precipitates in an epsilon copper matrix, brought about by the bombardment of thin foils with argon ions, has been studied using lattice fringe imaging. It is found, in general, that only partial transformation of individual particles occurs, this corresponding to a simple homogeneous shear (a Bain strain). In addition, the transformation is limited to particles located within about two particle diameters of the foil surface. It is established that the mere presence of a Frank (or Shockley) loop in a particle, due to the bombardment, is insufficient to trigger the transformation. The implications of this result are discussed with reference to bulk martensite. In the present case, it is concluded that transformation may simply initiate at sites of local decohesion or microslip at the matrix/particle boundaries brought about by vacancy condensation following ion bombardment, these sites being most effective in the vicinity of free surfaces
|
|
| 5. |
- Rundquist, I, et al.
(author)
-
Sciatic nerve blood flow measured by laser Doppler flowmetry and [14C]iodoantipyrine.
- 1985
-
In: American Journal of Physiology. - 0002-9513 .- 2163-5773. ; 248:3 Pt 2, s. H311-317
-
Journal article (peer-reviewed)abstract
- Blood flow was examined in sciatic nerves of pentobarbital-anesthetized rats by means of laser Doppler flowmetry (LDF) and intravenous [14C]iodoantipyrine infusion. Continuous LDF signals demonstrated slow oscillations and acute, pressure-related changes in flow. The steady-state LDF signal was related linearly to nerve blood flow, as measured with [14C]iodoantipyrine, in intact nerves and nerves stripped of the epineurium. In 14 intact nerves, nerve blood flow averaged 0.27 +/- 0.03 (SE) ml X min-1 X g-1, whereas it averaged 0.13 +/- 0.01 in 5 stripped nerves. Autoradiographs of [3H]-nicotine-infused nerves and intra-arterial injection of 57Co-labeled microspheres demonstrated that flow was not uniform throughout the nerve cross section. The results indicate that LDF can be used to examine nerve blood flow in vivo, demonstrate a linear relation between the LDF signal and flow, and establish absolute values for blood flow in intact and stripped nerves of the anesthetized rat.
|
|
| 6. |
- Smith, S M, et al.
(author)
-
Role of neutrophils in hemorrhagic shock-induced gastric mucosal injury in the rat
- 1987
-
In: Gastroenterology. - 0016-5085 .- 1528-0012. ; 93:3, s. 466-471
-
Journal article (peer-reviewed)abstract
- Gastric mucosal clearance of 51Cr-labeled red blood cells (51Cr-RBC) was measured in rats during a 30-min control period, a 30-min ischemic period (hemorrhage to 27 mmHg arterial pressure), and a 60-min reperfusion period (reinfusion of shed blood). In untreated (control) rats, a dramatic rise in the leakage of 51Cr-labeled red blood cells into the gastric lumen was observed during the reperfusion period. Treatment with neutrophil antiserum attenuated 51Cr-labeled red blood cell flux into the gastric lumen. Using the radioactive microsphere technique, neutrophil-depleted animals were shown to have higher blood flows in the ischemic period than the untreated rats. Bleeding of untreated rats to a mean arterial pressure of 40 mmHg resulted in blood flows that were not different from those in antiserum-treated rats bled to 27 mmHg and leakage of 51Cr-labeled red blood cells similar to that measured in antiserum-treated rats. The results of this study indicate that neutrophils play an important role in hemorrhagic shock-induced gastric bleeding.
|
|
