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Träfflista för sökning "WFRF:(Starodubova ES) srt2:(2010-2014)"

Search: WFRF:(Starodubova ES) > (2010-2014)

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  • Starodubova, ES, et al. (author)
  • Fusion to the Lysosome Targeting Signal of the Invariant Chain Alters the Processing and Enhances the Immunogenicity of HIV-1 Reverse Transcriptase
  • 2014
  • In: Acta naturae. - : Acta Naturae Ltd. - 2075-8251. ; 6:1, s. 61-68
  • Journal article (peer-reviewed)abstract
    • Intracellular processing of the antigen encoded by a DNA vaccine is one of the key steps in generating an immune response. Immunization with DNA constructs targeted to the endosomal-lysosomal compartments and to the MHC class II pathway can elicit a strong immune response. Herein, the weakly immunogenic reverse transcriptase of HIV-1 was fused to the minimal lysosomal targeting motif of the human MHC class II invariant chain. The motif fused to the N-terminus shifted the enzyme intracellular localization and accelerated its degradation. Degradation of the chimeric protein occurred predominantly in the lysosomal compartment. BALB/c mice immunized with the plasmid encoding the chimeric protein demonstrated an enhanced immune response, in the form of an increased antigen-specific production of Th1 cytokines, INF- and IL-2, by mouse splenocytes. Moreover, the majority of the splenocytes secreted both cytokines; i.e., were polyfunctional. These findings suggest that retargeting of the antigen to the lysosomes enhances the immune response to DNA vaccine candidates with low intrinsic immunogenicity.
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  • Result 1-3 of 3
Type of publication
journal article (3)
Type of content
peer-reviewed (3)
Author/Editor
Isaguliants, MG (3)
Starodubova, ES (3)
Karpov, VL (2)
Krotova, OA (2)
Kilpelainen, A (1)
Engstrom, G. (1)
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Latanova, AA (1)
Petkov, SP (1)
Heuts, F (1)
Kuzmenko, YV (1)
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University
Karolinska Institutet (3)
Language
English (3)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)

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