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Träfflista för sökning "WFRF:(Stephens K.) srt2:(2020-2023)"

Search: WFRF:(Stephens K.) > (2020-2023)

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1.
  • Kanai, M, et al. (author)
  • 2023
  • swepub:Mat__t
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  • Niemi, MEK, et al. (author)
  • 2021
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  • Butler-Laporte, G, et al. (author)
  • Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics Initiative
  • 2022
  • In: PLoS genetics. - : Public Library of Science (PLoS). - 1553-7404 .- 1553-7390. ; 18:11, s. e1010367-
  • Journal article (peer-reviewed)abstract
    • Host genetics is a key determinant of COVID-19 outcomes. Previously, the COVID-19 Host Genetics Initiative genome-wide association study used common variants to identify multiple loci associated with COVID-19 outcomes. However, variants with the largest impact on COVID-19 outcomes are expected to be rare in the population. Hence, studying rare variants may provide additional insights into disease susceptibility and pathogenesis, thereby informing therapeutics development. Here, we combined whole-exome and whole-genome sequencing from 21 cohorts across 12 countries and performed rare variant exome-wide burden analyses for COVID-19 outcomes. In an analysis of 5,085 severe disease cases and 571,737 controls, we observed that carrying a rare deleterious variant in the SARS-CoV-2 sensor toll-like receptor TLR7 (on chromosome X) was associated with a 5.3-fold increase in severe disease (95% CI: 2.75–10.05, p = 5.41x10-7). This association was consistent across sexes. These results further support TLR7 as a genetic determinant of severe disease and suggest that larger studies on rare variants influencing COVID-19 outcomes could provide additional insights.
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  • Falster, Daniel, et al. (author)
  • AusTraits, a curated plant trait database for the Australian flora
  • 2021
  • In: Scientific Data. - : Nature Portfolio. - 2052-4463. ; 8:1
  • Journal article (peer-reviewed)abstract
    • We introduce the AusTraits database - a compilation of values of plant traits for taxa in the Australian flora (hereafter AusTraits). AusTraits synthesises data on 448 traits across 28,640 taxa from field campaigns, published literature, taxonomic monographs, and individual taxon descriptions. Traits vary in scope from physiological measures of performance (e.g. photosynthetic gas exchange, water-use efficiency) to morphological attributes (e.g. leaf area, seed mass, plant height) which link to aspects of ecological variation. AusTraits contains curated and harmonised individual- and species-level measurements coupled to, where available, contextual information on site properties and experimental conditions. This article provides information on version 3.0.2 of AusTraits which contains data for 997,808 trait-by-taxon combinations. We envision AusTraits as an ongoing collaborative initiative for easily archiving and sharing trait data, which also provides a template for other national or regional initiatives globally to fill persistent gaps in trait knowledge.
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  • Result 1-10 of 25
Type of publication
journal article (17)
other publication (2)
conference paper (2)
research review (2)
Type of content
peer-reviewed (16)
other academic/artistic (7)
Author/Editor
Walker, R. (5)
Marshall, R. (5)
Clark, M. (5)
Lewis, J (5)
Price, D. (4)
Gupta, R. (4)
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Lee, S (4)
Knight, M (4)
Davies, A (4)
Griffiths, J. (3)
Hayashi, T. (3)
Jones, G. (3)
Li, Y. (3)
Nowak, S. (3)
Silva, J. (3)
Spagnolo, S. (3)
White, S. (3)
Yang, Y. (3)
Gao, Y. (3)
Tokunaga, K. (3)
Gupta, A. (3)
Martin, A. J. (3)
Martin, J. (3)
Mbarek, H (3)
Burgess, A (3)
Kaufman, M (3)
Taylor, D (3)
Oya, Y. (3)
Robinson, S. (3)
Nicassio, M. (3)
Okada, Y. (3)
Seo, J. (3)
Schneider, M. (3)
Foley, S. (3)
Garcia, J. (3)
Zhang, W. (3)
West, A. (3)
Wheeler, S. (3)
Smith, P. (3)
Morris, J. (3)
Wood, R (3)
Bowden, M. (3)
Svoboda, J (3)
Ali, M (3)
Biondi, A (3)
Gorini, G (3)
Khan, M (3)
Smith, A (3)
Scott, M (3)
Sridhar, S. (3)
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University
Karolinska Institutet (10)
Uppsala University (7)
University of Gothenburg (5)
Chalmers University of Technology (4)
Royal Institute of Technology (3)
Stockholm University (2)
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Lund University (2)
Linköping University (1)
Södertörn University (1)
Swedish University of Agricultural Sciences (1)
VTI - The Swedish National Road and Transport Research Institute (1)
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Language
English (25)
Research subject (UKÄ/SCB)
Natural sciences (10)
Medical and Health Sciences (6)
Engineering and Technology (3)
Social Sciences (1)
Humanities (1)

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