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Träfflista för sökning "WFRF:(Stromblad S) srt2:(2000-2004)"

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1.	Landolfi, R, et al. (author) Efficacy and safety of low-dose aspirin in polycythemia vera 2004 In: The New England journal of medicine. - 1533-4406. ; 350:2, s. 114-124 Journal article (peer-reviewed)
2.	Bao, WJ, et al. (author) Integrin alphav-mediated inactivation of p53 controls a MEK1-dependent melanoma cell survival pathway in three-dimensional collagen 2004 In: The Journal of cell biology. - : Rockefeller University Press. - 0021-9525 .- 1540-8140. ; 167:4, s. 745-756 Journal article (peer-reviewed)abstract Integrin αv is required for melanoma cell survival and tumor growth in various models. To elucidate integrin αv-mediated melanoma cell survival mechanisms, we used a three-dimensional (3D) collagen gel model mimicking the pathophysiological microenvironment of malignant melanoma in the dermis. We found that integrin αv inactivated p53 and that suppression of p53 activity by dominant negative p53 or p53-small interfering RNA obviated the need for integrin αv for melanoma cell survival in 3D-collagen and for tumor growth in vivo. This indicates that integrin αv-mediated inactivation of p53 functionally controls melanoma cell survival. Furthermore, we found that melanoma cell integrin αv was required for MAPK kinase (MEK) 1 and extracellular signal-regulated kinase (ERK)1/2 activity in 3D-collagen, whereas inhibition of MEK1 activity induced apoptosis. Surprisingly, MEK1 and ERK1/2 activities were restored in integrin αv-negative melanoma cells by suppression of p53, whereas concomitant block of MEK1 induced apoptosis. This suggests that integrin αv controls melanoma cell survival in 3D-collagen through a pathway involving p53 regulation of MEK1 signaling.
3.	Gad, A, et al. (author) Retinoblastoma susceptibility gene product (pRb) and p107 functionally separate the requirements for serum and anchorage in the cell cycle G1-phase 2004 In: The Journal of biological chemistry. - 0021-9258. ; 279:14, s. 13640-13644 Journal article (peer-reviewed)
4.	Pall, T, et al. (author) Recombinant CD44-HABD is a novel and potent direct angiogenesis inhibitor enforcing endothelial cell-specific growth inhibition independently of hyaluronic acid binding 2004 In: Oncogene. - : Springer Science and Business Media LLC. - 0950-9232 .- 1476-5594. ; 23:47, s. 7874-7881 Journal article (peer-reviewed)
5.	Zhang, HQ, et al. (author) Myosin-X provides a motor-based link between integrins and the cytoskeleton 2004 In: Nature cell biology. - : Springer Science and Business Media LLC. - 1465-7392 .- 1476-4679. ; 6:6, s. 523-531 Journal article (peer-reviewed)

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Result 1-5 of 5

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Type of publication: journal article (5)

Type of content: peer-reviewed (5)

Author/Editor: Stromblad, S (4); Hansen, S. (1); Torelli, G (1); Kramer, A (1); Collins, R (1); Tognoni, G. (1); show more...; Andreasson, B (1); Back, H. (1); Lang, P (1); Olivieri, M (1); Cervellera, M (1); Oscier, DG (1); Maggi, A (1); Kogerman, P (1); Bennett, M (1); Wang, YL (1); Eldor, A (1); Beretta, A (1); Falanga, A (1); Galli, M (1); Ranieri, G. (1); Di Francesco, A. (1); Zhang, HQ (1); Ellis, M (1); Rossi, G (1); Ruggeri, M (1); Larsson, G (1); Girschikofsky, M (1); Volpe, A (1); Fabbri, A. (1); Papaioannou, M. (1); Strandberg, M (1); Bao, WJ (1); Thullberg, M (1); Martinelli, V (1); Barbui, T (1); Marino, G (1); Finazzi, G. (1); Gisslinger, H. (1); Gugliotta, L. (1); Hehlmann, R (1); Passamonti, F (1); Bhaskar, A. (1); de Gaetano, G (1); Finelli, C (1); Stenke, L (1); Linder, O (1); Rodeghiero, F. (1); Garcia, G (1); Zanella, A. (1); show less...

University: Karolinska Institutet (5)

Language: English (5)

Year: 2004 (5)

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