| 1. |
- Ederth, Thomas, et al.
(author)
-
Resistance of Galactoside-Terminated Alkanethiol Self-Assembled Monolayers to Marine Fouling Organisms
- 2011
-
In: ACS Applied Materials and Interfaces. - : American Chemical Society. - 1944-8244 .- 1944-8252. ; 3:10, s. 3890-3901
-
Journal article (peer-reviewed)abstract
- Self-assembled monolayers (SAMs) of galactoside-terminated alkanethiols have protein-resistance properties which can be tuned via the degree of methylation [Langmuir 2005, 21, 2971-2980]. Specifically, a partially methylated compound was more resistant to nonspecific protein adsorption than the hydroxylated or fully methylated counterparts. We investigate whether this also holds true for resistance to the attachment and adhesion of a range of marine species, in order to clarify to what extent resistance to protein adsorption correlates with the more complex adhesion of fouling organisms. The partially methylated galactoside-terminated SAM was further compared to a mixed monolayer of omega-substituted methyl- and hydroxyl-terminated alkanethiols with wetting properties and surface ratio of hydroxyl to methyl groups matching that of the galactoside. The settlement (initial attachment) and adhesion strength of four model marine fouling organisms were investigated, representing both micro- and macrofoulers; two bacteria (Cobetia marina and Marinobacter hydrocarbonoclasticus), barnacle cypris larvae (Balanus amphitrite), and algal zoospores (Ulva linza). The minimum in protein adsorption onto the partially methylated galactoside surface was partly reproduced in the marine fouling assays, providing some support for a relationship between protein resistance and adhesion of marine fouling organisms. The mixed alkanethiol SAM, which was matched in wettability to the partially methylated galactoside SAM, consistently showed higher settlement (initial attachment) of test organisms than the galactoside, implying that both wettability and surface chemistry are insufficient to explain differences in fouling resistance. We suggest that differences in the structure of interfacial water may explain the variation in adhesion to these SAMs.
|
|
| 2. |
|
|
| 3. |
- Bellenguez, Celine, et al.
(author)
-
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke
- 2012
-
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 44:3, s. 141-328
-
Journal article (peer-reviewed)abstract
- Genetic factors have been implicated in stroke risk, but few replicated associations have been reported. We conducted a genome-wide association study (GWAS) for ischemic stroke and its subtypes in 3,548 affected individuals and 5,972 controls, all of European ancestry. Replication of potential signals was performed in 5,859 affected individuals and 6,281 controls. We replicated previous associations for cardioembolic stroke near PITX2 and ZFHX3 and for large vessel stroke at a 9p21 locus. We identified a new association for large vessel stroke within HDAC9 (encoding histone deacetylase 9) on chromosome 7p21.1 (including further replication in an additional 735 affected individuals and 28,583 controls) (rs11984041; combined P = 1.87 x 10(-11); odds ratio (OR) = 1.42, 95% confidence interval (CI) = 1.28-1.57). All four loci exhibited evidence for heterogeneity of effect across the stroke subtypes, with some and possibly all affecting risk for only one subtype. This suggests distinct genetic architectures for different stroke subtypes.
|
|
| 4. |
- Huang, Wei, et al.
(author)
-
Propeller-like D-pi-A architectures : bright solid emitters with AIEE activity and large two-photon absorption
- 2014
-
In: Journal of Materials Chemistry C. - : Royal Society of Chemistry (RSC). - 2050-7526 .- 2050-7534. ; 2:33, s. 6843-6849
-
Journal article (peer-reviewed)abstract
- Two novel molecules TABzPA and TATpPA with D-pi-A structure and large pi-conjugation have been synthesized via Wittig reaction. Unlike common molecules, which exhibit the aggregation-caused quenching (ACQ) phenomenon, TABzPA and TATpPA exhibit aggregation-induced emission enhancement (AIEE) activity: weak luminescence in common solvents but strong emission when aggregated as nanoparticles and solid powders. Due to their intramolecular charge transfer (ICT) attribution and AIEE features, TABzPA and TATpPA display bathochromic effects. Combining ICT and AIEE features, these molecules are intensely yellow solid emitters with high quantum efficiencies of about 23.2% and 24.1%. Moreover, TABzPA and TATpPA have excellent two-photon absorption (2PA) properties owing to good planarity and large pi-conjugation. The values of 2PA cross sections at 800 nm are 7590 GM and 7648 GM. The excellent optical properties of TABzPA and TATpPA pave the way for future potential applications in biophotonics and optoelectronics.
|
|
| 5. |
- Liu, Min, et al.
(author)
-
MCM2 expression levels predict diagnosis and prognosis in gastric cardiac cancer
- 2013
-
In: Histology and Histopathology. - 1699-5848. ; 28:4, s. 481-492
-
Journal article (peer-reviewed)abstract
- Background: Gastric Cardiac Cancer (GCC) has high incidence and poor prognosis requiring early screening of high-risk populations. Minichromosome maintenance (MCM) proteins are used as diagnostic-biomarkers in many cancers but not validated for GCC. We evaluate MCM protein 2 (MCM2), comparing it with the validated markers Ki67 and PCNA. Methods: GCC and corresponding cardiac precancerous samples were immunostained with Ki67, MCM2 and PCNA antibodies. Results: 90% of dysplasia samples expressed MCM2, whereas Ki67 and PCNA were expressed in 67% and 80% respectively. The sensitivity and negative predictive values of MCM2 were also superior at 90% and 87%, respectively. Ki67 and PCNA expression was correlated with MCM2, but their expressions seldom reached surface layers, whereas MCM2 manifested mostly in easily accessible superficial layers. Labeling indices (LI) of Ki67 and PCNA were also lower. Significant associations between LI (MCM2), LI (PCNA), and TNM-stages, lymph node metastases and GCC grade were found (P<0.05). Increased protein expressions were associated with reduced overall and disease-free survival (P<0.05). Although Ki67 and PCNA were significant prognostic factors, there was no significant improvement in multivariate statistical analyses, in contrast to LI (MCM2) findings. Conclusions: MCM2 is a sensitive, specific and efficient biomarker of GCC having potential use in clinic.
|
|
| 6. |
- Zhou, Haitao, et al.
(author)
-
New cyano-substituted organic dyes containing different electrophilic groups : aggregation-induced emission and large two-photon absorption cross section
- 2014
-
In: Tetrahedron. - : Elsevier BV. - 0040-4020 .- 1464-5416. ; 70:39, s. 7050-7056
-
Journal article (peer-reviewed)abstract
- Three aggregation-induced emission active dyes (3a-c) were synthesized and their one- and two-photon absorption properties have been investigated. They were all found to be weakly fluorescent in THF solution, while they exhibited dramatic fluorescence enhancement in water/THF mixtures. The solid fluorescence of 3a-c was recorded and their fluorescence quantum efficiency (Phi(F)) values were determined to be 8.0%, 8.1%, and 16.4%, respectively. Moreover, the two-photon absorption (2PA) cross-sections (sigma) of 3a-c were measured and 3a showed the highest value of 702 GM. The excellent aggregation-induced emission and 2PA properties provide a promising alternative for biophotonic materials.
|
|
