| 1. |
- Estrada, Karol, et al.
(author)
-
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
- 2012
-
In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 44:5, s. 491-501
-
Journal article (peer-reviewed)abstract
- Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. We tested the top BMD-associated markers for replication in 50,933 independent subjects and for association with risk of low-trauma fracture in 31,016 individuals with a history of fracture (cases) and 102,444 controls. We identified 56 loci (32 new) associated with BMD at genome-wide significance (P < 5 × 10(-8)). Several of these factors cluster within the RANK-RANKL-OPG, mesenchymal stem cell differentiation, endochondral ossification and Wnt signaling pathways. However, we also discovered loci that were localized to genes not known to have a role in bone biology. Fourteen BMD-associated loci were also associated with fracture risk (P < 5 × 10(-4), Bonferroni corrected), of which six reached P < 5 × 10(-8), including at 18p11.21 (FAM210A), 7q21.3 (SLC25A13), 11q13.2 (LRP5), 4q22.1 (MEPE), 2p16.2 (SPTBN1) and 10q21.1 (DKK1). These findings shed light on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility.
|
|
| 2. |
- Wang, Zhaoming, et al.
(author)
-
Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33
- 2014
-
In: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 23:24, s. 6616-6633
-
Journal article (peer-reviewed)abstract
- Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This region harbors the TERT and CLPTM1L genes; the former encodes the catalytic subunit of telomerase reverse transcriptase and the latter may play a role in apoptosis. To investigate further the genetic architecture of common susceptibility alleles in this region, we conducted an agnostic subset-based meta-analysis (association analysis based on subsets) across six distinct cancers in 34 248 cases and 45 036 controls. Based on sequential conditional analysis, we identified as many as six independent risk loci marked by common single-nucleotide polymorphisms: five in the TERT gene (Region 1: rs7726159, P = 2.10 × 10(-39); Region 3: rs2853677, P = 3.30 × 10(-36) and PConditional = 2.36 × 10(-8); Region 4: rs2736098, P = 3.87 × 10(-12) and PConditional = 5.19 × 10(-6), Region 5: rs13172201, P = 0.041 and PConditional = 2.04 × 10(-6); and Region 6: rs10069690, P = 7.49 × 10(-15) and PConditional = 5.35 × 10(-7)) and one in the neighboring CLPTM1L gene (Region 2: rs451360; P = 1.90 × 10(-18) and PConditional = 7.06 × 10(-16)). Between three and five cancers mapped to each independent locus with both risk-enhancing and protective effects. Allele-specific effects on DNA methylation were seen for a subset of risk loci, indicating that methylation and subsequent effects on gene expression may contribute to the biology of risk variants on 5p15.33. Our results provide strong support for extensive pleiotropy across this region of 5p15.33, to an extent not previously observed in other cancer susceptibility loci.
|
|
| 3. |
- Abelev, B., et al.
(author)
-
Measurement of the inclusive differential jet cross section in pp collisions at root s=2.76 TeV
- 2013
-
In: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 722:4-5, s. 262-272
-
Journal article (peer-reviewed)abstract
- The ALICE Collaboration at the CERN Large Hadron Collider reports the first measurement of the inclusive differential jet cross section at mid-rapidity in pp collisions at root s = 2.76 TeV, with integrated luminosity of 13.6 nb(-1). Jets are measured over the transverse momentum range 20 to 125 GeV/c and are corrected to the particle level. Calculations based on Next-to-Leading Order perturbative QCD are in good agreement with the measurements. The ratio of inclusive jet cross sections for jet radii R = 0.2 and R = 0.4 is reported, and is also well reproduced by a Next-to-Leading Order perturbative QCD calculation when hadronization effects are included. (c) 2013 CERN. Published by Elsevier B.V. All rights reserved.
|
|
| 4. |
- Baek, Seung Ki, et al.
(author)
-
Quantum Monte Carlo study of the transverse-field quantum Ising modelon infinite-dimensional structures
- 2011
-
In: Physical Review B Condensed Matter. - : American Physical Society. - 0163-1829 .- 1095-3795. ; 84, s. 174419-
-
Journal article (peer-reviewed)abstract
- In a number of classical statistical-physical models, there exists acharacteristic dimensionality called the upper critical dimension abovewhich one observes the mean-field critical behavior. Instead of constructinghigh-dimensional lattices, however, one can also considerinfinite-dimensional structures, and the question is whether this mean-fieldcharacter extends to quantum-mechanical cases as well. We thereforeinvestigate the transverse-field quantum Ising model on the globally couplednetwork and on the Watts-Strogatz small-world network by means of quantum MonteCarlo simulations and the finite-size scaling analysis. We confirm that bothof the structures exhibit critical behavior consistent with the mean-fielddescription. In particular, we show that the existing cumulant methodhas difficulty in estimating the correct dynamic critical exponent andsuggest that an order parameter based on the quantum-mechanicalexpectation value can be a practically useful numerical observable todetermine critical behavior when there is no well-defined dimensionality.
|
|
| 5. |
- Chang, Hou-Tai, et al.
(author)
-
Using service simulation to analyse the satisfaction with the processes of intensive care unit in the hospital: the perspective of the patient and the family
- 2013
-
In: Total Quality Management & Business Excellence. - : Informa UK Limited. - 1478-3363 .- 1478-3371. ; 24:7-8, s. 869-885
-
Journal article (peer-reviewed)abstract
- In the hospital, intensive care unit (ICU) is an isolated space where patients with acute symptoms are treated. When the patients are in ICU, their families are usually in psychological crisis and under great pressure. The value of ICU is thus to provide a complete ICU service by which not only the patients receive good treatment, but the feelings of family members are also considered and managed. In the study, we explored ICU value through finding the factors for the satisfaction of patients and their families. We first studied current ICU operations, identified its corresponding processes and built their process profiles. Then we used de facto ICU satisfaction survey questions and linked them to these process profiles. This linkage offered insights on how ICU processes influenced the satisfaction of the patient and the family. In order to improve the satisfaction with the ICU, we created a simulation model which was statistically tested as valid; then different scenarios of medical staff assignments were studied for their respective satisfaction results. The management decision of allocating adequate medical staff under various considerations can be achieved more precisely and objectively with the aid of this simulation model. The research is a pioneering study in satisfaction simulation for critical medical care. The research explores the satisfaction of critical care from the perspective of the patient and the family. It also expands the possibilities of applying discrete-event simulation in the study of ICU and other similar health-care processes.
|
|
| 6. |
- Chen, Jing-Ling, et al.
(author)
-
Quantum contextuality for a relativistic spin-1/2 particle
- 2013
-
In: Physical Review A. Atomic, Molecular, and Optical Physics. - 1050-2947 .- 1094-1622. ; 87:2, s. 022109-
-
Journal article (peer-reviewed)abstract
- The quantum predictions for a single nonrelativistic spin-1/2 particle can be reproduced by noncontextual hidden variables. Here we show that quantum contextuality for a relativistic electron moving in a Coulomb potential naturally emerges if relativistic effects are taken into account. The contextuality can be identified through the violation of noncontextuality inequalities. We also discuss quantum contextuality for the free Dirac electron as well as the relativistic Dirac oscillator. DOI: 10.1103/PhysRevA.87.022109
|
|
| 7. |
|
|
| 8. |
- Dahlgaard, Jens Jörn, et al.
(author)
-
Business excellence models: limitations, reflections and further development
- 2013
-
In: Total Quality Management & Business Excellence. - : Informa UK Limited. - 1478-3363 .- 1478-3371. ; 24:5-6, s. 519-538
-
Journal article (peer-reviewed)abstract
- The use of business excellence models (BEM) has become popular in the last two decades, and several companies have learned how to use them and gained from such models. More companies, we assume, have experienced problems when using such models because of various weaknesses such as too-sophisticated assessment criteria, excessive paperwork, cumbersome procedures and a lack of focus, which have limited its use in practice. To respond to some of those problems, a new overall business excellence framework (BEF) has been developed which recommends adaption instead of adoption of existing BEM. The suggested overall BEF helps to integrate BEM with management tools/techniques and the organisational culture/characteristics for guiding an organisation towards business excellence. A document-based empirical case of a world-class company, Boeing Aerospace Support, was investigated to illustrate how the overall BEF may work in practice as a complement to an existing BEM when companies adapt such models to their specific contexts.
|
|
| 9. |
|
|
| 10. |
- Dahlgaard-Park, Su Mi, et al.
(author)
-
Diagnosing and prognosticating the quality movement - a review on the 25 years quality literature (1987-2011)
- 2013
-
In: Total Quality Management and Business Excellence. - : Taylor and Francis (Routledge): SSH Titles. - 1478-3363 .- 1478-3371. ; 24:1-2, s. 1-18
-
Journal article (peer-reviewed)abstract
- The purpose of this article is to create a snapshot of 25 years quality movement. The creation process of the snapshot, as well as the result of the study, aims to help in diagnosing the current status of quality management (QM) and further contribute in understanding and shaping its future direction. For this purpose, all published articles during the last 25 years period (1987-2011) under the subject of Total Quality Management (TQM), Business Excellence (BE), quality tools, techniques as well as core values/principles have been collected through the ABI/INFORM complete periodical database. The collected data were analysed and reflected in order to show the current status, evolution trends of the past, and the predicted future directions. The results show that the total number of articles under the subject of TQM has been decreasing after having reached its peak in 1995. However, papers focusing on techniques and tools within the QM framework in terms of Lean, Just-in-Time/Toyota Production System, Benchmarking, and Six-Sigma Quality have been increasing. In addition, papers focusing on core values/key principles needed to build a quality culture in terms of leadership, people-based management, continuous improvements, management based on facts, and focus on the customer have been slightly increasing during the last decade. The findings indicate that QM is now at a more mature stage where focuses have shifted from being initially on TQM to tools, techniques, and core values which are needed for building a quality and BE culture. Based on its evolution, it is concluded that TQM can be understood as a management innovation, if not a management revolution.
|
|
