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Träfflista för sökning "WFRF:(Sundqvist L) srt2:(1980-1984)"

Search: WFRF:(Sundqvist L) > (1980-1984)

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1.
  • Hafstrom, L., et al. (author)
  • Blood flow in experimental liver tumors : Effect of vasoactive drugs
  • 1980
  • In: Acta Chirurgica Scandinavica. - 0001-5482. ; 146:3, s. 149-153
  • Journal article (peer-reviewed)abstract
    • The effects of infused glucagon, histamine and vasopressin on blood flow in anesthetized rats with intrahepatic tumors were studied using microspheres labelled with 99Tcm or 51Cr isotopes. Considerable circulatory effects were noted both in central hemodynamic parameters as well as in organ and tissue blood flows. Glucagon infusion increased blood flow in the spleen and small intestine while hepatic artery flow was unchanged. Histamine induced a decrease in hepatic and pulmonary blood flow. Vasopressin showed a pronounced decrease in blood flow in all organs measured. Relative tumor blood flow was registered as the ratio between tumor flow and arterial hepatic flow. A relative decrease of tumor blood flow in relation to surrounding liver tissue blood flow was registered after infusion of vasopressin. No effects were seen after glucagon or histamine infusion.
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2.
  • Nilsson, I. M., et al. (author)
  • Suppression of Secondary Antibody Response by Intravenous Immunoglobulin in a Patient with Haemophilia B and Antibodies
  • 1983
  • In: Scandinavian Journal of Haematology. - : Wiley. - 0036-553X. ; 30:5, s. 458-464
  • Journal article (peer-reviewed)abstract
    • A 39‐year‐old patient, suffering from severe haemophilia B and antibodies against factor IX, has twice been treated with extracorporeal protein A‐Sepharose adsorption followed by conventional substitution therapy in combination with immunosuppression (cyclophos‐phamide). On both occasions, separated by a 2‐year interval, the same procedure was followed except that, on the second, administration of i.v. immunoglobulin (Gammonativ, KabiVitrum) was added. Within a week of the first treatment the patient developed a 15‐fold increase in the antibody titre. Following the second treatment described here, no secondary antibody response could be detected, and after a further 12 weeks only traces of antibodies are demonstrable. It seems that antibody synthesis was suppressed by the i.v. immunoglobulin. No evidence was found to demonstrate that the effect was due either to a non‐specific suppression of the immune and reticuloendothelial systems or to the action of interfering antibodies. It has not yet been established whether or not the protein A‐Sepharose adsorption technique, or the immunosuppressive treatment, contributed in any way to the result. The observations suggest a new approach to the treatment of haemophiliacs with antibodies of the high‐responding type.
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  • Result 1-2 of 2
Type of publication
journal article (2)
Type of content
peer-reviewed (2)
Author/Editor
Holmberg, L (1)
Persson, B (1)
Freiburghaus, Catja (1)
Ljung, R (1)
Hafstrom, L. (1)
Sundqvist, K (1)
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Nilsson, I M (1)
Sundqvist, S. ‐B (1)
Björlin, G. (1)
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University
Lund University (2)
Language
English (2)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)

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