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Träfflista för sökning "WFRF:(Sung N) srt2:(2015-2019)"

Search: WFRF:(Sung N) > (2015-2019)

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  • Aad, G, et al. (author)
  • 2015
  • swepub:Mat__t
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  • Bixby, H., et al. (author)
  • Rising rural body-mass index is the main driver of the global obesity epidemic in adults
  • 2019
  • In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 569:7755, s. 260-4
  • Journal article (peer-reviewed)abstract
    • Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities(.)(1,2) This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity(3-6). Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean BMI segregated by place of residence (a rural or urban area) from 1985 to 2017. We show that, contrary to the dominant paradigm, more than 55% of the global rise in mean BMI from 1985 to 2017-and more than 80% in some low- and middle-income regions-was due to increases in BMI in rural areas. This large contribution stems from the fact that, with the exception of women in sub-Saharan Africa, BMI is increasing at the same rate or faster in rural areas than in cities in low- and middle-income regions. These trends have in turn resulted in a closing-and in some countries reversal-of the gap in BMI between urban and rural areas in low- and middle-income countries, especially for women. In high-income and industrialized countries, we noted a persistently higher rural BMI, especially for women. There is an urgent need for an integrated approach to rural nutrition that enhances financial and physical access to healthy foods, to avoid replacing the rural undernutrition disadvantage in poor countries with a more general malnutrition disadvantage that entails excessive consumption of low-quality calories.
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  • Justice, A. E., et al. (author)
  • Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
  • 2017
  • In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8
  • Journal article (peer-reviewed)abstract
    • Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.
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  • Result 1-10 of 54
Type of publication
journal article (53)
Type of content
peer-reviewed (52)
other academic/artistic (1)
Author/Editor
Peters, Annette (13)
Peters, A (12)
Gudnason, V (12)
Lehtimaki, T. (12)
Metspalu, A (12)
Lind, Lars (11)
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He, J (11)
Franks, Paul W. (10)
Vollenweider, P. (10)
Metspalu, Andres (10)
Tynelius, P. (10)
Evans, A. (9)
Lee, J. (9)
Fischer, K. (9)
Hofman, A (9)
Wareham, Nicholas J. (9)
Elliott, P (9)
Ridker, Paul M. (9)
Chasman, Daniel I. (9)
Langenberg, Claudia (9)
Scott, Robert A (9)
Tuomilehto, J. (9)
Christensen, K (9)
Sundström, Johan (9)
Linneberg, A. (9)
Sonestedt, Emily (9)
Xu, L. (8)
Kim, J. (8)
Jonas, JB (8)
Salomaa, Veikko (8)
Giwercman, Aleksande ... (8)
Raitakari, Olli T (8)
Ohlsson, Claes, 1965 (8)
Kuusisto, Johanna (8)
Laakso, Markku (8)
Muller-Nurasyid, M. (8)
Renström, Frida (8)
van Duijn, Cornelia ... (8)
Boehnke, Michael (8)
Chen, FF (8)
Zhao, WH (8)
Cooper, R (8)
Lehtimäki, Terho (8)
Gieger, Christian (8)
Strauch, Konstantin (8)
Stocks, Tanja (8)
Söderberg, Stefan (8)
Koskinen, S (8)
Salomaa, V (8)
Luan, Jian'an (8)
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Karolinska Institutet (38)
Lund University (29)
Umeå University (25)
Uppsala University (22)
University of Gothenburg (15)
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University of Skövde (6)
Chalmers University of Technology (5)
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Linköping University (2)
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Language
English (54)
Research subject (UKÄ/SCB)
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Natural sciences (12)
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