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- Kindbom, Karin, et al.
(author)
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Nationell miljöövervakning av luft- och nederbördskemi 1997, 1998 och 1999
- 2001
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Reports (other academic/artistic)abstract
- I föreliggande rapport redovisas resultat från 1997, 1998 och 1999 års mätningar av luftens och nederbördens sammansättning i bakgrundsmiljö i Sverige. Rapporten redovisar mätresultat från de båda nationella övervakningsnäten EMEP och Luft- och nederbördskemiska nätet. I rapporten redovisas även de spridnings- och depositionsberäkningar som gjorts med Sverigemodellen för 1997 och 1998. Samtliga mätningar drivs av IVL medan modellberäkningarna med Sverigemodellen utförs av SMHI
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- Kindbom, Karin, et al.
(author)
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Trends in air concentration and deposition at background monitoring sites in Sweden : Major inorganic compounds, heavy metals and ozone
- 2001
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Reports (other academic/artistic)abstract
- This report describes concentrations in air of sulphur compounds, soot, nitrogen compounds andozone in Sweden between 1985-1998. Time trends of concentration in precipitation and depositionof sulphate, nitrate, ammonium, acidity, base cations and chloride in six different regions coveringSweden are evaluated during the period 1983-1998. Trends of heavy metals in precipitation havebeen analysed for the period 1983-1998 and the change in heavy metal concentration, 1975-1995, inmosses is described.Data used in the trend analyses originates from measurements performed at six Swedish EMEPstations and from approximately 25 stations within the national Precipitation Chemistry Network.Two different statistical methods, linear regression and the non-parametric Mann Kendall test, havebeen used to evaluate changes in annual mean values.
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- Kjellgren, Karin I, 1950, et al.
(author)
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Antihypertensive treatment and patient autonomy--the follow-up appointment as a resource for care.
- 2000
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In: Patient education and counseling. - 0738-3991 .- 1873-5134. ; 40:1, s. 39-49
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Journal article (peer-reviewed)abstract
- Since hypertension is a chronic condition which generally requires long-term commitment to pharmacological therapy as well as alterations of patient lifestyle, the patient-physician communication in the clinical setting is an important determinant of the quality of care and health outcome. The aim of the present study was to explore the structure and content of the communication between the patient and the physician, and the process of decision-making at a routine follow-up appointment for hypertension. The study was based on 51 audio-recordings of authentic consultations. Most patients had a passive role in the consultations, and initiated few topics of conversation. The few topics that the patients initiated were usually not about hypertension. Patients' questions about medication mainly referred to unwanted effects of the drugs. Little time was invested in discussing risks related to hypertension. A collaborative shared decision-making was seldom observed in the consultations.
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- Aili, Carola, 1963-, et al.
(author)
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Research on teachers' professional lives : time to build a research network. Paper presented at NERA's 31st Congress, 6-9 March, Copenhagen
- 2003
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Conference paper (peer-reviewed)abstract
- Teachers’ work has during the last ten years gone through great changes. The effects of postmodern society has made the work more and morecomplex and difficult to handle and understand for those involved as well as outsiders. Researchers are trying to keep up with things. The developmentof knowledge of teachers’ work takes place on different levels, in separate disciplines, from various starting-points and with different foci.To be able to describe, understand and explain the »new« work of teachers in a vigorous way there is need of getting these research initiativestogether. Arenas should be established where interchanges and coordination between researchers could take place. In order to make this happen wehave the intention of building a Swedish (our aim is to expand the network to the Nordic countries after the establishment in Sweden) network ofresearch on teachers’ professional lives.Besides presenting the intention and design of our network we also bring along some examples of research projects in line with the network ideas.
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6. |
- Aili, Carola, et al.
(author)
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Research on teachers' professional lives : time to build a research network. Paper presented at NERA's 31st Congress, 6-9 March, Copenhagen
- 2003
-
Conference paper (other academic/artistic)abstract
- Teachers’ work has during the last ten years gone through great changes. The effects of postmodern society has made the work more and morecomplex and difficult to handle and understand for those involved as well as outsiders. Researchers are trying to keep up with things. The developmentof knowledge of teachers’ work takes place on different levels, in separate disciplines, from various starting-points and with different foci.To be able to describe, understand and explain the »new« work of teachers in a vigorous way there is need of getting these research initiativestogether. Arenas should be established where interchanges and coordination between researchers could take place. In order to make this happen wehave the intention of building a Swedish (our aim is to expand the network to the Nordic countries after the establishment in Sweden) network ofresearch on teachers’ professional lives.Besides presenting the intention and design of our network we also bring along some examples of research projects in line with the network ideas.
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9. |
- Carlsson, Karin, et al.
(author)
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Probing the interface between factor Xa and tissue factor in the quaternary complex tissue factor-factor VIIa-factor Xa-tissue factor pathway inhibitor
- 2003
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In: European Journal of Biochemistry. - : Wiley. - 0014-2956 .- 1432-1033. ; 270:12, s. 2576-2582
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Journal article (peer-reviewed)abstract
- Blood coagulation is triggered by the formation of a complex between factor VIIa (FVIIa) and its cofactor, tissue factor (TF). TF-FVIIa is inhibited by tissue factor pathway inhibitor (TFPI) in two steps: first TFPI is bound to the active site of factor Xa (FXa), and subsequently FXa-TFPI exerts feedback inhibition of TF-FVIIa. The FXa-dependent inhibition of TF-FVIIa activity by TFPI leads to formation of the quaternary complex TF-FVIIa-FXa-TFPI. We used site-directed fluorescence probing to map part of the region of soluble TF (sTF) that interacts with FXa in sTF-FVIIa-FXa-TFPI. We found that the C-terminal region of sTF, including positions 163, 166, 200 and 201, is involved in binding to FXa in the complex, and FXa, most likely via its Gla domain, is also in contact with the Gla domain of FVIIa in this part of the binding region. Furthermore, a region that includes the N-terminal part of the TF2 domain and the C-terminal part of the TF1 domain, i.e. the residues 104 and 197, participates in the interaction with FXa in the quaternary complex. Moreover, comparisons of the interaction areas between sTF and FX(a) in the quaternary complex sTF-FVIIa-FXa-TFPI and in the ternary complexes sTF-FVII-FXa or sTF-FVIIa-FX demonstrated large similarities.
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10. |
- Carlsson, Karin, et al.
(author)
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Site-directed fluorescence probing to dissect the calcium-dependent association between soluble tissue factor and factor VIIa domains
- 2003
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In: Biochimica et Biophysica Acta - Proteins and Proteomics. - 1570-9639 .- 1878-1454. ; 1648:1-2, s. 12-16
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Journal article (peer-reviewed)abstract
- We have used the site-directed labeling approach to study the Ca 2+-dependent docking of factor VIIa (FVIIa) to soluble tissue factor (sTF). Nine Ca2+ binding sites are located in FVIIa and even though their contribution to the overall binding between TF and FVIIa has been thoroughly studied, their importance for local protein-protein interactions within the complex has not been determined. Specifically we have monitored the association of the ?-carboxyglutamic acid (Gla), the first EGF-like (EGF1), and the protease domains (PD) of FVIIa to sTF. Our results revealed that complex formation between sTF and FVIIa during Ca2+ titration is initiated upon Ca2+ binding to EGF1, the domain containing the site of highest Ca2+ affinity. Besides we showed that a Ca 2+-loaded Gla domain is required for an optimal association of all domains of FVIIa to sTF. Ca2+ binding to the PD seems to be of some importance for the docking of this domain to sTF. © 2003 Elsevier Science B.V. All rights reserved.
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