| 1. |
- Batta, Gy., et al.
(author)
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C‐19 configurational assignments in some morphine derivatives by homonuclear NOE
- 1992
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In: Magnetic Resonance in Chemistry. - : Wiley. - 0749-1581 .- 1097-458X. ; 30:13, s. S96-S104
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Journal article (peer-reviewed)abstract
- Azidolysis‐thermolysis of C‐19 diastereomer tosyl esters of morphine derivatives resulted in the formation of a new substituted 4‐azatetracyclo [4.4.02,4.03,8] decane ring system. As the course of such transformations depends on the chirality of C‐19, its relative configuration was determined both in the starting materials and in the new compounds. To this end a semiquantitative 1H{1H} NOE interpretation was combined with MMX molecular mechanics. Interestingly, both in the starting materials with a rotating C‐7—C‐19 bond and in the fairly rigid aziridine ring‐containing products, the same (H‐8α{19‐Me}) NOE effects were the most informative on the stereochemistry. In addition full a priori 1H and 13C assignments of 13 compounds are presented.
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| 2. |
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| 3. |
- Csende, F., et al.
(author)
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Synthesis and structural study of new saturated isoindol-1-one derivatives
- 1993
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In: Heterocycles. - : The Japan Institute of Heterocyclic Chemistry. - 0385-5414 .- 1881-0942. ; 36:8, s. 1809-1821
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Journal article (peer-reviewed)abstract
- Condensation of 2-p-toluoylcyclohexanecarboxylic acid (1a,b) with primary amines gave the corresponding hexahydroisoindol-1-ones (2a-g) in good yield. The octahydro derivatives (4a-g) were prepared from cis- and trans-hexahydro-1(2H)-phthalazinone (3a,b) by reduction with zinc-hydrochloric acid via ring contraction. Stereoselective synthesis of cis-N-phenyloctahydroisoindol-1-one (4h) was performed starting from 2b by reduction with magnesium-methanol at room temperature. Configurational assignments of cis and trans isomers were based on 1H-and 13C-nmr spectroscopic studies.
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| 4. |
- Kóródi, F., et al.
(author)
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Fused 1,2,4-triazole heterocycles. I. Synthesis of novel [1,2,4]triazolo[5′,1′:2,3][1,3]thiazino[6,5-b]quinolines
- 1992
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In: Heterocycles. - : The Japan Institute of Heterocyclic Chemistry. - 0385-5414 .- 1881-0942. ; 34:9, s. 1711-1720
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Journal article (peer-reviewed)abstract
- Derivatives of a new heterocyclic ring system of [1,2,4]triazolo[5′,1′: 2,3][1,3]thiazino[6,5-b]quinolines (4,5,6,7 and 8) have been synthesised by the reaction of 2-chloroquinoline-3-carbaldehyde derivatives (1 and 2) with 1,2,4-triazole-5-thiols (3), and subsequent transformations of the hydroxy group of 11-hydroxy[1,2,4]triazolo[5′,1′: 2,3][1,3]thiazino[6,5-b]quinoline (4a).
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| 5. |
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| 6. |
- Marton, J., et al.
(author)
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Herstellung von 6,14‐Ethenomorphinan‐Derivaten
- 1993
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In: Liebigs Annalen der Chemie. - : Wiley. - 0170-2041 .- 1099-0690. ; 1993:8, s. 915-919
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Journal article (peer-reviewed)abstract
- Preparation of 6,14‐Ethenomorphinane Derivatives Buprenorphine (5j) and diprenorphine (5k) were synthesized from N‐formyl‐northebaine (1c) and N‐benzyl‐northebaine (1d) via new intermediates. N‐cyclopropylmethyl‐dihydronorthevinone 3d is a suitable compound for the synthesis of both 5j and 5k. We carried out detailed 1H‐ and 13C‐NMR analysis of the new compounds.
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| 7. |
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| 8. |
- Szabo, Zoltan, Associate professor, et al.
(author)
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1H and 13C NMR study of novel fused 1,2,4‐triazole heterocycles
- 1992
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In: Magnetic Resonance in Chemistry. - : Wiley. - 0749-1581 .- 1097-458X. ; 30:11, s. 1111-1116
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Journal article (peer-reviewed)abstract
- The 1H and 13C NMR spectra of some novel 1,2,4‐triazolo [1,3] thiazinoquinoline isomeric pairs are interpreted in terms of structural assignments. The structure of most compounds has been confirmed by NOE difference spectroscopy. Characteristic differences have been observed in both 1H and 13C NMR spectra of these isomeric Pairs: some of the 1H and 13C chemical shifts, and also the one bond 13C1H couplings of triazole protons, differ consistently in the NMR spectra of the isomers. The coupling constants have been determined using a combination of INEPT and chemical shift selective filtering.
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| 9. |
- Szabó, Zoltan, Associate professor, et al.
(author)
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Interpretation of the 13C NMR spectra of 3‐benzylideneflavanones, 3‐benzylflavone and 3‐benzyl‐1‐thioflavone derivatives
- 1993
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In: Magnetic Resonance in Chemistry. - : Wiley. - 0749-1581 .- 1097-458X. ; 31:4, s. 418-421
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Journal article (peer-reviewed)abstract
- 13C NMR spectra of 3‐benzylflavones, 3‐benzylideneflavanones, 3‐benzyl‐4‐thioflavones, 3‐benzyl‐1‐thioflavones, 3‐benzyl‐1,4‐dithioflavones and 3‐benzyl‐1‐thioflavone‐1,1‐dioxides were analysed and correlated to evaluate the consequences of the replacement of oxygen with sulphur.
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| 10. |
- Szabó, Zoltan, Associate professor, et al.
(author)
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Synthesis and biological activity of 4‐aikoxy‐ and 4‐ω‐aminoalkoxy‐2‐trichloromethylquinolines
- 1991
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In: Pesticide science. - : Wiley. - 0031-613X .- 1096-9063. ; 31:3, s. 263-271
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Journal article (peer-reviewed)abstract
- A number of new 4‐alkoxy‐ and 4‐ω‐aminoalkoxy‐2‐trichloromethyl‐quinolines were synthesised and tested on insects, weeds and plant pathogens. Many of these compounds showed antifungal activity against different fungal species. Some compounds, IVa, IVb, IVc, Vb, Vc and VI, had interesting effects on Phycomycete fungi.
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