| 1. |
- Batta, Gy., et al.
(author)
-
C‐19 configurational assignments in some morphine derivatives by homonuclear NOE
- 1992
-
In: Magnetic Resonance in Chemistry. - : Wiley. - 0749-1581 .- 1097-458X. ; 30:13, s. S96-S104
-
Journal article (peer-reviewed)abstract
- Azidolysis‐thermolysis of C‐19 diastereomer tosyl esters of morphine derivatives resulted in the formation of a new substituted 4‐azatetracyclo [4.4.02,4.03,8] decane ring system. As the course of such transformations depends on the chirality of C‐19, its relative configuration was determined both in the starting materials and in the new compounds. To this end a semiquantitative 1H{1H} NOE interpretation was combined with MMX molecular mechanics. Interestingly, both in the starting materials with a rotating C‐7—C‐19 bond and in the fairly rigid aziridine ring‐containing products, the same (H‐8α{19‐Me}) NOE effects were the most informative on the stereochemistry. In addition full a priori 1H and 13C assignments of 13 compounds are presented.
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
- Szecsi, J, et al.
(author)
-
[Effect of acute aprotinin (Gordox) therapy on hemostasis in heart surgery patients, with special reference to hyperfibrinolysis] : [Article in Hungarian]
- 1990
-
In: Orvosi Hetilap. - : Akademiai Kiado Rt.. - 0030-6002 .- 1788-6120. ; 131:51, s. 2809-2814
-
Journal article (peer-reviewed)abstract
- Authors have studied the effect of Gordox-therapy on haemostasis after open heart surgery in a prospective clinical trial. Thirty seven patients (pts) undergoing cardiac surgery due to their valve disease were randomly assigned either to control-group (20 pts) or to Gordox-group (17 pts). The patients in the Gordox group were given Gordox according the following scheme: 2 M IU within 20 min. after induction of anaesthesia followed by 0.5 M IU/hour infusion until the end of the operation. One M IU also was given into the oxygenator before starting the extracorporeal circulation. The postoperative chest tube drainage was less in Gordox-group (534 +/- 260 ml vs. 987 +/- 583 ml, p less than 0.005), and donor blood and fresh frozen plasma requirement was also lower in this group (534 +/- 633 ml vs. 935 +/- 718 ml p less than 0.05; 70 +/- 153 ml vs. 211 +/- 245 ml p less than 0.05, respectively). There was no significant difference between the two groups concerning the postoperative activated partial thromboplastin time, prothrombin time, thrombin time values. The authors could document significantly higher fibrinogen concentration and significantly lower fibrinolytic activity postoperatively in the Gordox-group (p less than 0.05). Gordox therapy has advantageous effect on haemostasis after open heart surgery which can be documented both by clinical and laboratory examination.
|
|
| 6. |
- Tóth, I., et al.
(author)
-
Extraction of gallium(III) and aluminium(III) with O,O-dialkyldithiophosphoric acids
- 1990
-
In: Talanta. - : Elsevier BV. - 0039-9140 .- 1873-3573. ; 37:12, s. 1175-1178
-
Journal article (peer-reviewed)abstract
- The extraction of Ga3+ and Al3+ with the liquid cation-exchangers di-n-butyldithiophosphoric acid (DBTPA) and di-(2-ethylhexyl)dithiophosphoric acid (DETPA) in kerosene, in the presence and absence of alcohols and tri-n-butyl phosphate (TBP) has been studied. Both Ga3+ and Al3+ can be extracted in the form of a neutral complex, MA3, but the distribution coefficient of Ga3+ is the higher by about two orders of magnitude, which can be the basis of the solvent extraction separation of gallium and aluminium. The differences can be explained by the interaction between the sulphur donor atoms of the extractants and the d10 electronic shell of Ga3+ as well as by the lower steric hindrance of ligands co-ordinated to Ga3+.
|
|
