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Träfflista för sökning "WFRF:(Tanabe R.) srt2:(2020-2023)"

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1.	Taylor, J., et al. (author) Postoperative delirium and changes in the blood–brain barrier, neuroinflammation, and cerebrospinal fluid lactate: a prospective cohort study 2022 In: British Journal of Anaesthesia. - : Elsevier BV. - 0007-0912. ; 129:2, s. 219-230 Journal article (peer-reviewed)abstract Background: Case-control studies have associated delirium with blood–brain barrier (BBB) permeability. However, this approach cannot determine whether delirium is attributable to high pre-existing permeability or to perioperative changes. We tested whether perioperative changes in cerebrospinal fluid/plasma albumin ratio (CPAR) and plasma S100B were associated with delirium severity. Methods: Participants were recruited to two prospective cohort studies of non-intracranial surgery (NCT01980511, NCT03124303, and NCT02926417). Delirium severity was assessed using the Delirium Rating Scale-98. Delirium incidence was diagnosed with the 3D-Confusion Assessment Method (3D-CAM) or CAM-ICU (CAM for the ICU). CSF samples from 25 patients and plasma from 78 patients were analysed for albumin and S100B. We tested associations between change in CPAR (n=11) and S100B (n=61) and delirium, blood loss, CSF interleukin-6 (IL-6), and CSF lactate. Results: The perioperative increase in CPAR and S100B correlated with delirium severity (CPAR ρ=0.78, P=0.01; S100B ρ=0.41, P<0.001), delirium incidence (CPAR P=0.012; S100B P<0.001) and CSF IL-6 (CPAR ρ=0.66 P=0.04; S100B ρ=0.75, P=0.025). Linear mixed-effect analysis also showed that decreased levels of S100B predicted recovery from delirium symptoms (P=0.001). Linear regression demonstrated that change in plasma S100B was independently associated with surgical risk, cardiovascular surgery, blood loss, and hypotension. Blood loss also correlated with CPAR (ρ=0.64, P=0.04), S100B (ρ=0.70, P<0.001), CSF lactate (R=0.81, P=0.01), and peak delirium severity (ρ=0.36, P=0.01). Conclusion: Postoperative delirium is associated with a breakdown in the BBB. This increased permeability is dynamic and associated with a neuroinflammatory and lactate response. Strategies to mitigate blood loss may protect the BBB. © 2022 British Journal of Anaesthesia
2.	Bajard, L, et al. (author) Application of AOPs to assist regulatory assessment of chemical risks - Case studies, needs and recommendations 2023 In: Environmental research. - : Elsevier BV. - 1096-0953 .- 0013-9351. ; 217, s. 114650- Journal article (peer-reviewed)
3.	Clerbaux, LA, et al. (author) COVID-19 through Adverse Outcome Pathways: Building networks to better understand the disease - 3rd CIAO AOP Design Workshop 2022 In: ALTEX. - : ALTEX Edition. - 1868-8551 .- 1868-596X. ; 39:2, s. 322-335 Journal article (other academic/artistic)
4.	Li, M, et al. (author) FXYD3 functionally demarcates an ancestral breast cancer stem cell subpopulation with features of drug-tolerant persisters 2023 In: The Journal of clinical investigation. - 1558-8238. ; 133:22 Journal article (peer-reviewed)
5.	Li, MJ, et al. (author) FXYD3 functionally demarcates an ancestral breast cancer stem cell subpopulation with features of drug-tolerant persisters 2023 In: The Journal of clinical investigation. - 1558-8238. ; 133:22 Journal article (peer-reviewed)
6.	Tanabe, S, et al. (author) Cohort study into the neural correlates of postoperative delirium: the role of connectivity and slow-wave activity 2020 In: British journal of anaesthesia. - : Elsevier BV. - 1471-6771 .- 0007-0912. ; 125:1, s. 55-66 Journal article (peer-reviewed)
7.	Tsuji, N, et al. (author) Frequent HLA-DR loss on hematopoietic stem progenitor cells in patients with cyclosporine-dependent aplastic anemia carrying HLA-DR15 2022 In: Leukemia. - : Springer Science and Business Media LLC. - 1476-5551 .- 0887-6924. ; 36:6, s. 1666-1675 Journal article (peer-reviewed)
8.	Tsuji, N, et al. (author) Frequent HLA-DR loss on hematopoietic stem progenitor cells in patients with cyclosporine-dependent aplastic anemia carrying HLA-DR15 (vol 36, pg 1666, 2022) 2023 In: LEUKEMIA. - 0887-6924. Journal article (other academic/artistic)

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Result 1-8 of 8

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Type of publication: journal article (8)

Type of content: peer-reviewed (6); other academic/artistic (2)

Author/Editor: Ogawa, S. (4); Tanabe, S (4); Tanabe, M (4); Suzuki, Y. (2); Wang, K. (2); Takeuchi, Y. (2); show more...; Sato, S. (2); Nomura, S (2); Tsuji, N. (2); Yamashita, T. (2); Okamoto, K. (2); Uchida, Y. (2); Ota, T. (2); Hosokawa, K (2); Nishimura, T. (2); Akiyama, T. (2); Ishikawa, S (2); Shimamura, T (2); Nakagawa, M (2); Sugano, S. (2); Gotoh, N (2); Beronius, A (2); Wittwehr, C (2); Cheng, X. (2); Foukakis, T (2); Katoh, M (2); Nakao, S (2); Liu, CC (2); Hirose, H (2); Kishi, H (2); Katagiri, T (2); Asahara, H (2); Ozawa, T (2); Nakato, R (2); Yamazaki, H (2); Kanai, A (2); Chiba, T (2); Ishiyama, K (2); Hongu, T (2); Shiokawa, D (2); Sasahara, A (2); Yano, M (2); Inokuchi, M (2); Tada, KI (2); Miyagi, Y (2); Nagai, LAE (2); Tojo, A (2); Voon, DC (2); Takamatsu, H (2); Urushihara, R (2); show less...

University: Karolinska Institutet (7); University of Gothenburg (1); Swedish University of Agricultural Sciences (1)

Language: English (8)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

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