| 1. |
- Yang, Jia-Xiang, et al.
(author)
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Facile synthesis, optical properties and theoretical calculation of two novel two-photon absorption chromophores
- 2010
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In: Journal of Luminescence. - : Elsevier BV. - 0022-2313 .- 1872-7883. ; 130:4, s. 654-659
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Journal article (peer-reviewed)abstract
- Two heterocycle-based derivatives that can be used as two-photon absorption chromophore, 9-butyl-3-(2,6-diphenylpyridin-4-yl)-9H-carbazole (BDPYC) and 9-butyl-3-(4-(2, 6-diphenylpyridin-4-yl)styryl)-9H-carbazole (BDPSC) have been successfully synthesized and fully characterized by elemental analysis, IR, H-1 NMR, C-13 NMR and MS. The molecules possess D-pi-A structures, but have different pi bridge. The 9-butylcarbazole is used as a donor (D), and the pyridine ring is used as an acceptor (A). One- and two-photon absorption and excited fluorescence properties in various solvents were experimentally investigated. Two-photon initiated optical data recording experiments have been carried Out under 740 nm laser radiation, and the possible mechanism of optical data storage is discussed based on theoretical calculations.
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| 2. |
- Cheng, Hao, et al.
(author)
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Nanoparticles with aggregation-induced emission for monitoring long time cell membrane interactions
- 2013
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In: Progress In Electromagnetics Research. - 1070-4698 .- 1559-8985. ; 140, s. 313-325
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Journal article (peer-reviewed)abstract
- We perform the long time monitoring of nanoparticle-cell membrane interaction with high spatial and temporal resolution. The 2, 3-bis(4-(pheny1(4-(1, 2, 2-triphenylvinyl) phenyl)amino)phenyl) fumaronitrile (TPE-TPA-FN) is doped in organically modified silica (ORMOSIL) to be a biocompatible nanoprobe, which displays an aggregation-induced emission (ATE) effect. Photobleaching resistance of this synthesized nanoparticle is tested and compared with its similar counterpart, which proves its superiority and capability of long term fluorescence emission. We utilize the objective-based total internal reflection microscopy combined with the living cell incubation platform to investigate the cell uptake process of this nanoparticle in real time.
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| 3. |
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| 4. |
- Lindgren, Lars-Erik, et al.
(author)
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Simplified multiscale resolution theory for elastic material with damage
- 2011
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In: Computational plasticity XI : fundamentals and applications. - Barcelona : CINME. - 9788489925731 ; , s. 576-586
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Conference paper (peer-reviewed)abstract
- The multiscale resolution continuum theory (MRCT) is a higher order continuum mechanics. A particle is represented by a point that is deformable. This enables the possibility to include the effect of microstructure features in the continuum model on the deformation behavior through additional nodal variables for the higher order scale. This reduces the need for a very fine mesh in order to resolve microstructure details. It is possible to further reduce the computational effort by keeping the additional degree of freedoms to a minimum by tailoring the theory to specific phenomena. The latter is illustrated in a simplified context for an elastic material with damage.
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| 5. |
- Qin, Hao, et al.
(author)
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Multiscale resolution continuum theory for elastic plastic material with damage, an implicit 3D implementation
- 2013
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In: Computational Plasticity XII. - Barcelona. - 9788494153150 ; , s. 1448-1457
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Conference paper (peer-reviewed)abstract
- The multiscale resolution continuum theory (MRCT) [1] is a higher order continuum theory in which additional kinematic variables are added to account for the size effect at several distinct length scales. This remedies the deficiency of the conventional continuum approach when predicting both strain softening and strain hardening materials and resolves the microstructure details without extremely fine mesh in the localization zone, however additional nodal degrees of freedom are needed and the requirement of element size at the length scale somewhat adds to the computational burden. This paper is an extension of the simplified 1D multiscale implementation presented in Complas XI 2011 [14]. A 3D elastic-plastic multiscale element, with one additional subscale in which the damage is applied, is implemented implicitly in the general purpose finite element analysis program FEAP.
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| 6. |
- Tang, Zhongshu, et al.
(author)
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Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3β phosphorylation
- 2010
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In: Journal of Experimental Medicine. - : The Rockefeller University Press. - 0022-1007 .- 1540-9538. ; 207:4, s. 867-880
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Journal article (peer-reviewed)abstract
- Platelet-derived growth factor CC (PDGF-CC) is the third member of the PDGF family discovered after more than two decades of studies on the original members of the family, PDGF-AA and PDGF-BB. The biological function of PDGF-CC remains largely to be explored. We report a novel finding that PDGF-CC is a potent neuroprotective factor that acts by modulating glycogen synthase kinase 3beta (GSK3beta) activity. In several different animal models of neuronal injury, such as axotomy-induced neuronal death, neurotoxin-induced neuronal injury, 6-hydroxydopamine-induced Parkinson's dopaminergic neuronal death, and ischemia-induced stroke, PDGF-CC protein or gene delivery protected different types of neurons from apoptosis in both the retina and brain. On the other hand, loss-of-function assays using PDGF-C null mice, neutralizing antibody, or short hairpin RNA showed that PDGF-CC deficiency/inhibition exacerbated neuronal death in different neuronal tissues in vivo. Mechanistically, we revealed that the neuroprotective effect of PDGF-CC was achieved by regulating GSK3beta phosphorylation and expression. Our data demonstrate that PDGF-CC is critically required for neuronal survival and may potentially be used to treat neurodegenerative diseases. Inhibition of the PDGF-CC-PDGF receptor pathway for different clinical purposes should be conducted with caution to preserve normal neuronal functions.
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