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Träfflista för sökning "WFRF:(Terasmaa A) srt2:(1999)"

Search: WFRF:(Terasmaa A) > (1999)

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  • Rinken, A, et al. (author)
  • Serotonergic agonists behave as partial agonists at the dopamine D2 receptor
  • 1999
  • In: NeuroReport. - : Ovid Technologies (Wolters Kluwer Health). - 1473-558X .- 0959-4965. ; 10:3, s. 493-495
  • Journal article (peer-reviewed)abstract
    • RAT dopamine D2short receptors expressed in CHO cells were characterized by activation of [35S]GTPgammaS binding. There were no significant differences between the maximal effects seen in activation of [35S]GTPgammaS binding caused by dopaminergic agonists, but the effects of 5-HT, 8OH-DPAT and 5-methoxytryptamine amounted to 47 +/- 7%, 43 +/- 5% and 70 +/- 7% of the dopamine effect, respectively. The dopaminergic antagonist (+)butaclamol inhibited activations of both types of ligands with equal potency (pA2 = 8.9 +/- 0.1), indicating that only one type of receptor is involved. In competition with [3H]raclopride binding, dopaminergic agonists showed 53 +/- 2% of the binding sites in the GTP-dependent high-affinity state, whereas 5-HT showed only 20 +/- 3%. Taken together, the results indicate that serotonergic agonists behave as typical partial agonists for D2 receptors with potential antiparkinsonian activity.
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  • Result 1-2 of 2
Type of publication
conference paper (1)
journal article (1)
Type of content
other academic/artistic (1)
peer-reviewed (1)
Author/Editor
Fuxe, K (2)
Terasmaa, A (2)
Rinken, A (2)
FERRE, S (1)
Owman, Christer (1)
University
Karolinska Institutet (2)
Lund University (1)
Language
English (2)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
1999 (2)Undo refine

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