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Träfflista för sökning "WFRF:(Terasmaa A) srt2:(2000)"

Search: WFRF:(Terasmaa A) > (2000)

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  • Terasmaa, A, et al. (author)
  • Modulation of [(35)S]GTPgammaS binding to chinese hamster ovary cell membranes by D(2(short)) dopamine receptors
  • 2000
  • In: Neuroscience Letters. - 0304-3940. ; 280:2, s. 135-138
  • Journal article (peer-reviewed)abstract
    • Rat dopamine D(2short) expressed in Chinese hamster ovary (CHO) cells were characterized by means of activation of [(35)S]-guanosine 5'-O-(gamma-thiotriphosphate) ([(35)S]GTPgammaS) binding and inhibition of [(3)H]raclopride binding. Among 18 dopaminergic ligands studied dopamine, NPA, apomorphine and quinpirole were full agonists in activation of [(35)S]GTPgammaS binding, while seven ligands were partial agonists with efficacies from 16 to 69% of the effect of dopamine and seven ligands were antagonists having no effect on the basal level of [(35)S]GTPgammaS binding, but inhibited dopamine-dependent activation in a dose-response manner. Despite the different efficacies, the potencies of all 18 ligands to modulate [(35)S]GTPgammaS binding revealed a good correlation with their potencies to inhibit [(3)H]raclopride binding in the CHO cell membranes. This indicates that the binding of the ligand to the receptor determines its potency, but has no direct correlation with its intrinsic activity.
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  • Result 1-3 of 3
Type of publication
journal article (3)
Type of content
peer-reviewed (3)
Author/Editor
Fuxe, K (3)
Terasmaa, A (3)
Rinken, A (3)
FERRE, S (2)
Andbjer, B (1)
Owman, C (1)
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Owman, Christer (1)
Finnman, UB (1)
Finnman, U B (1)
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University
Karolinska Institutet (2)
Lund University (1)
Language
English (3)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
2000 (3)Undo refine

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